Patient selection may affect gene therapy success: Dominant negative effects observed for ornithine transcarbamylase in mouse and human hepatocytes

Journal of Clinical Investigation

Volumn 97, Issue 3, 1996, Pages 826-832

  Morsy, Manal A ^a,c   Zhao, J Z ^a,c   Ngo, Tham T ^a   Warman, Arthur W ^a   O'Brien, William E ^a   Graham, Frank L ^b   Caskey, C Thomas ^a,c  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MCMASTER UNIVERSITY   (Canada)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

adenovirus; hyperammonemia; liver; ornithine transcarbamylase; urea cycle

Indexed keywords

COMPLEMENTARY DNA; ORNITHINE CARBAMOYLTRANSFERASE;

ADENOVIRUS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE THERAPY; HUMAN; HUMAN CELL; HYPERAMMONEMIA; LIVER CELL CULTURE; MOUSE; NONHUMAN; PATIENT SELECTION; PRIORITY JOURNAL; TREATMENT OUTCOME; UREA CYCLE;

EID: 0030040201     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118482     Document Type: Article

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