Prognostic implications of response to preoperative infusional chemoradiation in locally advanced rectal cancer

Radiotherapy and Oncology

Volumn 51, Issue 2, 1999, Pages 153-160

  Janjan, Nora A ^a   Abbruzzese, James ^a   Pazdur, Richard ^a   Khoo, Vincent S ^a   Cleary, Karen ^a   Dubrow, Ronelle ^a   Ajani, Jaffer ^a   Rich, Tyvin A ^a   Goswitz, Mary S ^a   Evetts, Phyllis A ^a   Allen, Pamela K ^a   Lynch, Patrick M ^a   Skibber, John M ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Preoperative infusional chemoradiation; Rectal cancer

Indexed keywords

FLUOROURACIL;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIMODALITY CANCER THERAPY; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; PROGNOSIS; RECTUM CANCER; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; CHEMOTHERAPY, ADJUVANT; FEMALE; FLUOROURACIL; HUMANS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PREOPERATIVE CARE; PROGNOSIS; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS; SURVIVAL ANALYSIS;

EID: 0033064546     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-8140(99)00054-7     Document Type: Article

References (24)

1. Midgley R.S., Kerr D.J. Adjuvant treatment of colorectal cancer. Cancer Treatment Reviews. 23:1997;135-152.
2. Zaniboni A. Adjuvant chemotherapy in colorectal cancer with high-dose leucovorin and fluorouracil: impact on disease-free survival and overall survival. J. Clin. Oncol. 15:1997;2432-2441.
3. Moertel C.G., Fleming T.R., Macdonald J.S., et al. Fluorouracil plus levamisole as effective adjuvant therapy after resection of stage III colon carcinoma: a final report. Annals of Int. Med. 122:1995;321-326.
4. Fisher B., Wolmark N., Rockette H., et al. Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01. J. Natl. Cancer Inst. 80:1988;21-29.
5. Krook J.E., Moertel C.G., Gunderson L.L., et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N. Engl. J. Med. 324:1991;709-715.
6. Mendenhall W.M., Bland K.I., Souba W.W., Sombeck M.D., Copeland E.M., Million R.R. Preoperative irradiation for clinically resectable rectal adenocarcinoma. Seminars in Rad. Oncol. 3:1993;48-54.
7. Marks G., Mohiuddin M., Masoni L., Montori. High-dose preoperative radiation therapy as the key to extending sphincter-preservation surgery for cancer of the distal rectum. Surg. Oncol. Clinics of North America. 1:(1):1992;71-86.
8. Randomised trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cancer. Lancet. 348:1996;1605-1610.
9. Martijn H., de Neve W., Lybeert M.L.M., Crommelin M.A., Ribot J.G. Adjuvant postoperative radiotherapy for adenocarcinoma of the rectum and rectosigmoid - a retrospective analysis of locoregional control, survival, and prognostic factors on 178 patients. Am. J. Clin. Oncol. 18:(4):1995;277-281.
10. Gunderson L.L., Martenson J.A. Postoperative adjuvant irradiation with or without chemotherapy for rectal carcinoma. Seminars in Rad. Oncol. 3:(1):1993;55-63.
11. Freedman G.M., Coia L.R. Adjuvant and neoadjuvant treatment of rectal cancer. Seminars in Oncol. 22:1995;611-624.
12. Glimelius B., Isacsson U., Jung B., Pahlman L. Radiotherapy in addition to radical surgery in rectal cancer: evidence for a dose-response effect favoring preoperative treatment. Int. J. Rad. Oncol. Biol. Phys. 37:1997;281-287.
13. Pahlman L., Glimelius B. Pre or postoperative radiotherapy in rectal and rectosigmoid carcinoma-report from a randomized multicenter trial. Ann. Surg. 211:1990;187-195.
14. Frykholm G.J., Glimelius B., Pahlman L. Preoperative or postoperative irradiation in adenocarcinoma of the rectum: final treatment results of a randomized trial and an evaluation of late secondary effects. Dis. Colon Rectum. 36:1993;564-572.
15. Randomized study on preoperative radiotherapy in rectal carcinoma. Ann. Surg. Oncol. 3:1996;423-430.
16. Cedermark B., Johansson H., Rutqvist L.E., Wilking N. The Stockholm I Trial of preoperative short term radiotherapy in operable rectal carcinoma-a prospective randomized trial. Cancer. 75:1995;2269-2275.
17. Improved survival with preoperative radiotherapy in resectable rectal cancer. N. Engl. J. Med. 336:1997;980-987.
18. Berger C., de Muret A., Garaud P., et al. Preoperative radiotherapy (RT) for rectal cancer: predictive factors of tumor downstaging and residual tumor cell density (RTCD): Prognostic implications. Int. J. Rad. Oncol. Biol. Phys. 37:1997;619-627.
19. Rich T.A., Skibber J.M., Ajani J.A., et al. Preoperative infusional chemoradiation therapy for Stage T3 rectal cancer. Int. J. Rad. Oncol. Biol. Phys. 32:1995;1025-1029.
20. Minsky B.D., Cohen A.M., Enker W.E., et al. Preoperative 5-FU, low-dose leucovorin, and radiation therapy for locally advanced and unresectable rectal cancer. Int. J. Rad. Oncol. Biol. Phys. 37:1997;289-295.
21. O'Connell M.J., Martenson J.A., Wieand H.S., et al. Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N. Engl. J. Med. 331:1994;502-507.
22. Kaplan E.L., Meier P. Nonparametric estimation from incomplete observations. J. Am. Stat. Assoc. 53:1958;457-481.
23. Harris E., Albert A. Survivorship analysis for clinical studies. 1991;Marcel Dekker, Inc, New York.
24. Altman D. Practical statistics for medical research. 1991;Chapman and Hall, London.