Preoperative chemoradiation with cisplatin and 5-fluorouracil for extraperitoneal T3 rectal cancer: Acute toxicity, tumor response, sphincter preservation

International Journal of Radiation Oncology Biology Physics

Volumn 45, Issue 5, 1999, Pages 1175-1184

  Valentini, Vincenzo ^a   Coco, Claudio ^a   Cellini, Numa ^a   Picciocchi, Aurelio ^a   Rosetto, Maria Elena ^a   Mantini, Giovanna ^a   Marmiroli, Luca ^a   Barbaro, Brunella ^b   Cogliandolo, Santa ^a   Nuzzo, Gennaro ^a   Tedesco, Manfredo ^c   Ambesi Impiombato, Fabrizio ^c   Cosimelli, Maurizio ^c   Rotman, Marvin ^d  

^a CATHOLIC UNIVERSITY   (Italy)

^b Istituto di Radiologia di Universita Cattolica del Sacro Cuore di Roma   (Italy)

^c REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^d SUNY DOWNSTATE MEDICAL CENTER   (United States)

Author keywords

Combined modality therapy; Infusional chemotherapy; Preoperative radiotherapy; Rectal neoplasms; Sphincter saving procedure

Indexed keywords

CISPLATIN; FLUOROURACIL; MITOMYCIN;

ACUTE TOXICITY; ADULT; AGED; ANUS SPHINCTER; ARTICLE; BEAM THERAPY; BLOOD TOXICITY; CANCER ADJUVANT THERAPY; CANCER STAGING; CLINICAL ARTICLE; HUMAN; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; RADIATION RESPONSE; RECTUM CANCER; TREATMENT OUTCOME; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; ANAL CANAL; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CISPLATIN; COMBINED MODALITY THERAPY; DRUG ADMINISTRATION SCHEDULE; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HUMANS; INFUSIONS, INTRAVENOUS; MALE; MIDDLE AGED; NEOPLASM STAGING; RADIOTHERAPY DOSAGE; RECTAL NEOPLASMS;

EID: 0032785542     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(99)00301-6     Document Type: Article

References (57)

1. Prolongation of the disease-free interval in surgically treated rectal carcinoma. N Engl J Med. 312:1985;1465-1472.
2. Treurniet Donker A.D., van Putten W.L., Wereldsma J.C. Postoperative radiation therapy for rectal cancer An interim analysis of a prospective, randomized multicenter trial in The Netherlands . Cancer. 67:1991;2028-2042.
3. Bentzen S.M., Balslev I., Pedersen M., Teglbjaerg P.S., Hanberg Sorensen F., Bone J., Jacobsen N.O., Sell A., Overgaard J., Bertelsen K. Time to loco-regional recurrence after resection of Dukes' B and C colorectal cancer with or without adjuvant postoperative radiotherapy A multivariate regression analysis . Br J Cancer. 65:1992;102-107.
4. Arnaud J.P., Nordlinger B., Bosset J.F., Boes G.H., Sahmoud T., Schlag P.M., Pene F. Radical surgery and postoperative radiotherapy as combined treatment in rectal cancer Final results of a phase III study of the European Organization for Research and Treatment of Cancer . Br J Surg. 84:1997;352-357.
5. Fisher B., Wolmark N., Rockette H., Redmond C., Deutsch M., Wickerham D.L., Fisher E.R., Caplan R., Jones J., Lerner H. Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer Results from NSABP protocol R-01 . J Natl Cancer Inst. 80:1988;21-29.
6. Randomized trial of surgery alone versus surgery followed by radiotherapy for mobile cancer of the rectum. Lancet. 348:1996;1610-1614.
7. Krook J.E., Moertel C.G., Gunderson L.L., Wieand H.S., Collins R.T., Beart R.W., Kubista T.P., Poon M.A., Meyers W.C., Mailliard J.A. Effective surgical adjuvant therapy for high-risk rectal carcinoma [see comments]. N Engl J Med. 324:1991;709-715.
8. Tveit K.M., Guldvog I., Trondsen E., Harbitz T., Nygaard K., Nilsen J.B., Wist E., Hannisdal E. Randomized controlled trial of postoperative radiotherapy and short term time-scheduled 5-fluorouracil against surgery alone in the treatment of Dukes B and C rectal cancer. Norwegian Adjuvant Rectal Cancer Project Group. Br J Surg. 84:1997;1130-1135.
9. Cedermark B., Johansson H., Rutqvist L.E., Wilking N. The Stockholm I trial of preoperative short term radiotherapy in operable rectal carcinoma. Cancer. 75:1995;2269-2275.
10. Marsh P.J., James R.D., Schofield P.F. Adjuvant preoperative radiotherapy for locally advanced rectal carcinoma Results of a prospective, randomized trial . Dis Colon Rectum. 37:1994;1205-1214.
11. Goldberg P.A., Nicholls R.J., Porter N.H., Love S., Grimsey J.E. Long-term results of a randomised trial of short-course low-dose adjuvant pre-operative radiotherapy for rectal cancer Reduction in local treatment failure . Eur J Cancer. 30A:1994;1602-1606.
12. Randomized study on preoperative radiotherapy in rectal carcinoma [see comments]. Ann Surg Oncol. 3:1996;423-430.
13. Proceeding: Innovative Options in Rectal Cancer Management. An International Consensus Type Meeting. Philadelphia: Ciné-Med; 1997.
14. Pahlman L. Swedish Rectal Cancer Trial Initial report from a Swedish multicentre study examining the role of preoperative irradiation in the treatment of patients with resectable rectal carcinoma . Br J Surg. 80:1993;1333-1336.
15. Gerard A., Buyse M., Nordlinger B. Preoperative radiotherapy as adjuvant treatment in rectal cancer Final results of a randomized study of the European Organization for Research and Treatment of Cancer (EORTC) . Ann Surg. 208:1988;606-614.
16. Reis Neto J., Quilici F., Reis A. Preoperative radiotherapy in rectal carcinoma. Dis Colon Rectum. 32:1989;702-710.
17. Randomized trial of surgery alone versus radiotherapy followed by surgery for potentially operable locally advanced rectal cancer. Lancet. 348:1996;1605-1610.
18. Chari R.S., Tyler D.S., Anscher M.S., Russell L., Clary B.M., Hathorn J., Seigler H.F. Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum. Ann Surg. 221:1995;778-786.
19. Grann A., Minsky B.D., Cohen A.M., Saltz L., Guillen J.G., Paty P.B., Kelsen D.P., Kemeny N., Ilson D., Bass-Loeb J. Preliminary results of preoperative 5-fluorouracil, low-dose leucovorin and concurrent radiation therapy for clinically resectable T3 rectal cancer. Dis. Colon Rectum. 40:1997;515-522.
20. Rich T.A., Skibber J.M., Ajani J.A., Buchholz D.J., Cleary K.R., DuBrow R.A., Levin B., Lynch P.M., Materissian S.H., Roubein L.D., Ota D.M. Preoperative infusional chemoradiation therapy for stage T3 rectal cancer. Int J Radiat Oncol Biol Phys. 32:1995;1025-1029.
21. Valentini V., Coco C., Cellini N., Picciocchi A., Genovesi D., Mantini G., Barbaro B., Cogliandolo S., Mattana C., Tedesco M., Ambesi-Impiombato F., Cosimelli M. Preoperative chemoradiation for extraperitoneal T3 rectal cancer Acute toxicity, tumor response, sphincter preservation . Int J Radiat Oncol Biol Phys. 40,5:1998;1067-1075.
22. O'Connell M.J., Martenson J.A., Wieand H.S. Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery. N Engl J Med. 331:1994;502-507.
23. UICC International Union Against Cancer TNM classification of malignant tumours. 4th ed., 2nd revision. Berlin: Springer Verlag; 1992.
24. Marano P., Barbaro B., De Franco A., Vecchioli A., Cellini N., Valentini V., Coco C., Doglietto G.B., Vecchio F.M. Diagnostic and therapeutic integration in rectal cancer Preliminary notes . Radiol Med Torino. 84:1992;261-273.
25. Scott J., Huskisson E.C. Graphic representation of pain. Pain. 2:1976;175-181.
26. Minsky B.D., Cohen A.M., Enker W.E., Sigurdson E. Phase I/II trial of pre-operative radiation therapy and coloanal anastomosis in distal invasive resectable rectal cancer. Int J Radiat Oncol Biol Phys. 23:1992;387-392.
27. International Commission on Radiation Units and Measurements. ICRU Report 50: Prescribing, recording and reporting photon beam therapy. 1993.
28. Capirci C., Polico C., Mandoliti C., Stevanin C. Control of small bowel motion and set up errors during box pelvic treatment, using the new "Up Down Table" device (Abstr). Radiother Oncol. 32:(Suppl. 1):1994;S41.
29. Perez CA, Brady LW. Overview. In: Perez CA, Brady LW. Principles and practice of radiation oncology. 2nd ed. Philadelphia: Lippincott; 1992. p 1-62.
30. Miller A.B. Reporting results of cancer treatment. Cancer. 47:1981;207-214.
31. Brown M.B., Benedetti J.K. Sampling behavior of tests for correlation in two-way contingency tables. J Am Stat Assoc. 72:1977;309-315.
32. 2 tests. Biometrics. 10:1954;417-441.
33. Afifi A.A., Clark V. Computer-aided multivariate analysis. 2nd ed. 1990;Lifetime Learning Publications, Belmont, CA.
34. Vietti J., Eggerdine F., Valeriote F. Combined effect of x-radiation and 5-FU on survival of transplanted leukemic cells. J Natl Cancer Inst. 47:1971;865-870.
35. Byfield JE. Theoretical basis and clinical applications of 5-fluorouracil as a radiosensitizer - an overview. In: Rotman M, Rosenthal CJ. Concomitant continuous infusion chemotherapy and radiation. Berlin: Springer Verlag; 1991; p. 115-127.
36. Byfield J.E., Calabro-Jones P., Klisak I., Kulhanian F. Pharmacologic requirements for obtaining sensitization of human tumor cells in vitro to combined 5-fluorouracil or Ftorafur and X rays. Int J Radiat Oncol Biol Phys. 8:1982;1923-1933.
37. Byfield J.E., Frankel S.S., Sharp T.R., Hornbeck C.L., Callipari F.B. Phase I and pharmacologic study of 72-hour infused 5-fluorouracil and hyperfractionated cyclical radiation. Int J Radiat Oncol Biol Phys. 11:1985;791-800.
38. Begg A.C., van der Kolk Dewit L., Bartelink H. The interaction of cisplatinum and radiation on RIF-1 tumours cells in vitro. Int J Radiat Biol. 5:1986;871-884.
39. Dewit L. Combined treatment of radiation and cis-diamminochloroplatinum (II) A review of experimental and clinical data . Int J Radiat Oncol Biol Phys. 13:1987;403-426.
40. Douple E.B., Richmond R.C. Radiosensitization of hypoxic tumor cells by cis- and trans-dichlorodiammineplatinum (II). Int J Radiat Oncol Biol Phys. 5:1979;1369-1372.
41. Carde P., Laval F. Effect of cis-diamminochloroplatinum (II) and X-rays on mammalian cell survival. Int J Radiat Oncol Biol Phys. 7:1981;929-933.
42. Ziegler W., Losher B. Der Effekt einer kombinierten Behandlung mit Cisplatin und Bestrahlung auf das Uberleben von Chinesischen Hamsterzellen. Strahlentherapie. 161:1985;636-641.
43. Alvarez M.V., Cobreros G., et al. Studies on cis-diamminochloroplatinum (II) as a radiosensitizer. Br J Cancer. 37:1978;68-72.
44. Rosenthal C.J., Rotman M., Choi K., Aziz H., Nuthakki M. Cisplatin (P) as radiopotentiator Dose and time intensity limitations of its administration by continuous intravenous infusion (CI) (Abstr) . Proc Annu Meet Am Soc Clin Oncol. 10:1991;A339.
45. Leipzig B. Cisplatin sensitization to radiotherapy of squamous cell carcinoma of the head and neck. Am J Surg. 146:1983;462-465.
46. Reimer R.R., Gahbauer R., Bukowski R.M., Hewlett J.S., Groppe C.W., Weick J.K. Jr, Antunez A.R. Simultaneous treatment with cisplatin and radiation therapy for advanced solid tumors A pilot study . Cancer Treat Rep. 65:1981;219-222.
47. Resbeut M., Cowen D., Viens P., et al. Concomitant chemoradiation prior to surgery in the treatment of advanced cervical carcinoma. Gynecol Oncol. 54:1994;68-75.
48. Dewit L., Oussoren Y., Bartelink H., et al. The effect of cis-diamminodichloroplatinum (II) on radiation in mouse rectum after fractionated irradiation. Radiother Oncol. 16:1989;121-128.
49. Stewart J.R., Hoff S.J., et al. Improved survival with neoadjuvant therapy and resection for adenocarcinoma of the esophagus. Ann Surg. 218:1993;571-576.
50. Walsh T.N., Noonan N., Hollywood D., Kelly A., Keeling N., Hennessy T. A comparison of multimodal therapy and surgery for esophageal adenocarcinoma. N Engl J Med. 335:1996;462-467.
51. Yunhua B., Xiaochao Y., et al. Cisplatin as a radiosensitizer in clinical practice A pilot study . Tumori. 77:1991;21-24.
52. Ellerbroek N.A., Fossella F.V., Rich T.A., et al. Low-dose continuous infusion cisplatin combined with external beam irradiation for advanced colorectal adenocarcinoma and unresectable non-small cell lung carcinoma. Int J Radiat Oncol Biol Phys. 20:1991;351-355.
53. Shumate C.R., Rich T.A., et al. Preoperative chemotherapy and radiation therapy for locally advanced primary and recurrent rectal carcinoma A report of surgical morbidity . Cancer. 71:1993;3690-3696.
54. Barbaro B., Schulsinger A., Valentini V., Marano P., Rotman M. The accuracy of transrectal ultrasound in predicting the pathological stage of low-lying rectal cancer after preoperative chemoradiation therapy. Int J Radiat Oncol Biol Phys. 43:1999;1043-1047.
55. Minsky B.D., Cohen A., Enker W., Kelsen D., Kemeny N., Ilson D., Guillem J., Paty P.B., Saltz L., Bass J., Conti J. Preoperative 5-FU, low dose leucovorin, and radiation therapy for locally advanced/unresectable rectal cancer. Int J Radiat Oncol Biol Phys. 37:1997;289-295.
56. Willett C.G., Warland G., Hagan M.P., Daly W.J., Coen J., Shellito P.C., Compton C.C. Tumor proliferation in rectal cancer following preoperative irradiation. J Clin Oncol. 13:1995;1417-1424.
57. Cionini L., Panichi M., De Paoli A., Pizzi G.B., Tomio L., Latini P., Cartei F., Maurizi R., Valentini V., Torretta A., Ponticelli P. Preoperative radiotherapy (RT) and concomitant 5-fluorouracil (5-FU) and folinic acid (FA) in locally advanced low rectal cancer (Abstr). Radiother Oncol. 40:(Suppl. 1):1996;38.