Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230

Journal of Medicinal Chemistry

Volumn 44, Issue 4, 2001, Pages 627-632

  Pelyvas I F ^a   Toth Z G ^a   Vereb, G ^b   Balla, A ^b   Kovacs E ^a   Gorzsas A ^a   Sztaricskai, F ^a   Gergely, P ^b  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

3 AZIDO 2 BENZOYLOXY 5 HYDROXYCYCLOHEXANONE; CYCLOHEXANONE DERIVATIVE; ENZYME INHIBITOR; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL KINASE; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; DERIVATIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

ANIMALS; CATTLE; CYCLOHEXANONES; ENZYME INHIBITORS; ISOENZYMES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); STRUCTURE-ACTIVITY RELATIONSHIP; SUGAR ALCOHOLS;

EID: 0035865908     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm001081c     Document Type: Article

References (30)

1. Phosphoinositide kinases
2. Phosphoinositide lipids as signaling molecules: Common themes for signal transduction, cytoskeletal regulation, and membrane trafficking
3. Phosphatidylinositol 4-kinases
4. Phosphatidylinositol 4-kinases
5. Cloning and characterization of a 92 kDa soluble phosphatidylinositol 4-kinase
6. Cloning, expression, and localization of 230-kDa phosphatidylinositol 4-kinase
7. Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase
8. Inositol lipid pathways turn turtle
9. Phosphoinositides as regulators in membrane traffic
10. Isolation and structure determination of novel phosphatidylinositol kinase inhibitors, echiguanines A and B, from Streptomyces sp.
11. Characterization of a soluble adrenal phosphatidylinositol 4-kinase reveals wortmannin sensitivity of type III phosphatidylinositol kinases
12. Isolation and molecular cloning of wortmannin-sensitive bovine type III phosphatidylinositol 4-kinases
13. A new cyclitol derivative influences inositol metabolism in Neurospora crassa
14. Synthesis of new anhydro and branched-chain cyclitols
15. Synthesis of new pseudodisaccharide aminoglycoside antibiotics from carbohydrates
16. Novel approach to aminocyclitol analogues from azidotrideoxyhex-5-enopyranosides
17. Novel aspects of the Ferrier carbocyclic ring-transformation reaction
18. Synthesis of optically active isoquinuclidines utilizing a diastereoselectivity control element
19. Synthesis of two useful, enantiomerically pure derivatives of (S)-4-hydroxy-2-cyclohexenone
20. Carbocyclic ring closure of an aminodeoxy hex-5-enopyranoside
21. Influenza Neuraminidase inhibitors possessing a novel hydrephobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity
22. A general method for the synthesis of amines by the rearrangement of allylic trichloroacetimidates. 1,3-Transposition of alcohol and amine functions
23. Structure of type II β-phosphatidylinositol phosphate kinase: A protein kinase fold flattened for interracial phosphorylation
24. Structural insights into phosphoinositide 3-kinase catalysis and signaling
25. Structure and function of phosphoinositide 3-kinases
26. 2 on the Golgi complex
27. Immunohistochemical localisation of two phosphatidylinositol 4-kinase isoforms, PI4K230 and PI4K92, in the central nervous system of rats
28. Localization of two type III phosphatidylinositol 4-kinase enzyme mRNAs in the rat
29. Identification of a 200 kDa polypeptide as type 3 phosphatidylinositol 4-kinase from bovine brain by partial protein and cDNA sequencing
30. Intracellular localization of inositol-phospholipid-metabolizing enzymes in rabbit fast-twitch skeletal muscle. Can D-myo-inositol 1,4,5-trisphosphate play a role in excitation-contraction coupling?