The pitx2 homeobox protein is required early for endoderm formation and nodal signaling

Developmental Biology

Volumn 229, Issue 2, 2001, Pages 287-306

  Faucourt, Marion ^a   Houliston, Evelyn ^a   Besnardeau, Lydia ^a   Kimelman, David ^b   Lepage, Thierry ^a  

^a LABORATOIRE D OCÉANOGRAPHIE DE VILLEFRANCHE   (France)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Antivin; Endoderm; Goosecoid; Homeobox; Nodal signaling; Pitx2; Rieger syndrome; Sox 17; Xbra; Xenopus; Zebrafish

Indexed keywords

HOMEODOMAIN PROTEIN; RNA;

ARTICLE; CONTROLLED STUDY; EMBRYO; ENDODERM; GENE EXPRESSION; HOMEOBOX; IN SITU HYBRIDIZATION; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; XENOPUS; ZEBRA FISH;

XENOPUS;

EID: 0035862734     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2000.9950     Document Type: Article

References (89)

1. Endodermal Nodal-related signals and mesoderm induction in Xenopus
2. Casanova plays an early and essential role in endoderm formation in zebrafish
3. The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities
4. Identification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 gene
5. Regulation of midline development by antagonism of lefty and nodal signaling
6. Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer
7. Activation of Siamois by the Wnt pathway
8. The homeobox gene Pitx2: Mediator of asymmetric left-right signaling in vertebrate heart and gut looping
9. Mechanisms of left-right determination in vertebrates
10. The lefty-related factor Xatv acts as a feedback inhibitor of nodal signaling in mesoderm induction and L-R axis development in Xenopus
11. Molecular nature of Spemann's organizer: The role of the Xenopus homeobox gene goosecoid
12. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction
13. Mode of action of VegT in mesoderm and endoderm formation
14. A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
15. Inhibition of Xbra transcription activation causes defects in mesodermal patterning and reveals autoregulation of Xbra in dorsal mesoderm
16. Vertebrate development: Multiple phases to endoderm formation
17. Fate map for the 32-cell stage of Xenopus laevis
18. Activin signalling has a necessary function in Xenopus early development
19. A novel Xenopus mix-like gene milk involved in the control of the endomesodermal fates
20. Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer
21. Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms
22. Nodal-related signals establish mesendodermal fate and trunk neural identity in zebrafish
23. Zebra fish organizer development and germ-layer formation require nodal-related signals
24. Pituitary homeobox2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation
25. Dosage requirement of Pitx2 for development of multiple organs
26. Responses of embryonic Xenopus cells to activin and FGF are separated by multiple dose thresholds and correspond to distinct axes of the mesoderm
27. Nodal signaling patterns the organizer
28. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
29. In situ hybridization, an improved whole mount method for Xenopus embryos
30. The cyclops mutation blocks specification of the floor plate of the zebrafish central nervous system
31. TGF-beta signals and a pattern in Xenopus laevis endodermal development
32. Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus
33. Xsox17alpha and -beta mediate endoderm formation in Xenopus
34. Regulation of the early expression of the Xenopus nodal-related 1 gene, Xnr1
35. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation
36. Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation
37. Origin and organization of the zebrafish fate map
38. Mouse Pitx2 deficiency leads to anomalies of the ventral body wall, heart, extra- and periocular mesoderm and right pulmonary isomerism
39. Mesoderm induction in Xenopus is a zygotic event regulated by maternal VegT via TGFbeta growth factors
40. Neural induction by the secreted polypeptide noggin
41. Goosecoid and mix.1 repress Brachyury expression and are required for head formation in Xenopus
42. The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteins
43. A role for the vegetally expressed Xenopus gene Mix.1 in endoderm formation and in the restriction of mesoderm to the marginal zone
44. Expression cloning of Siamois, a Xenopus homeobox gene expressed in dorsal-vegetal cells of blastulae and able to induce a complete secondary axis
45. A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate
46. Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
47. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals
48. Function of Rieger syndrome gene in left-right asymmetry and craniofacial development
49. A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation
50. Activin-induced factors maintain goosecoid transcription through a paired homeodomain binding site
51. Lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal
52. Mouse Otlx2/RIEG expression in the odontogenic epithelium precedes tooth initiation and requires mesenchyme-derived signals for its maintenance
53. Mesodermal patterning by a gradient of the vertebrate homeobox gene goosecoid
54. Smad2 role in mesoderm formation, left-right patterning and craniofacial development
55. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse
56. Xenopus nodal-related signaling is essential for mesendodermal patterning during early embryogenesis
57. Conversion of zebrafish blastomeres to an endodermal fate by TGF-beta-related signaling
58. The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals
59. Pitx2 participates in the late phase of the pathway controlling left-right asymmetry
60. Cyclops encodes a nodal-related factor involved in midline signaling
61. Induction of the mesendoderm in the zebrafish germ ring by yolk cell-derived TGF-beta family signals and discrimination of mesoderm and endoderm by FGF
62. Pitx2 determines left-right asymmetry of internal organs in vertebrates
63. Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling
64. Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes
65. The one-eyed pinhead gene functions in mesoderm and endoderm formation in zebrafish and interacts with no tail
66. Nodal signalling in vertebrate development
67. Pitx2 isoforms: Involvement of Pitx2c but not Pitx2a or Pitx2b in vertebrate left-right asymmetry
68. Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome
69. Expression of a Xenopus homolog of brachyury (T) is an immediate-early response to mesoderm induction
70. The type II activin receptors are essential for egg cylinder growth, gastrulation, and rostral head development in mice
71. Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish
72. One-eyed pinhead is required for development of the ventral midline of the zebrafish (Danio rerio) neural tube
73. Derriere: A TGF-beta family member required for posterior development in Xenopus
74. Bix1, a direct target of Xenopus T-box genes, causes formation of ventral mesoderm and endoderm
75. Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction
76. Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas
77. A single amino acid can determine the DNA binding specificity of homeodomain proteins
78. Transcriptional properties of ptx1 and ptx2 isoforms
79. Formation of the definitive endoderm in mouse is a Smad2-dependent process
80. Expression of achaetescute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate
81. Origin and development of the zebrafish endoderm
82. Conserved requirement for EGF-CFC genes in vertebrate left-right axis formation
83. A two-step model for the fate determination of presumptive endodermal blastomeres in Xenopus embryos
84. Pitx2, a bicoid-type homeobox gene, is involved in a lefty-signaling pathway in determination of left-right asymmetry
85. The role of maternal VegT in establishing the primary germ layers in Xenopus embryos
86. Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation