Insulin and analogue effects on protein degradation in different cell types. Dissociation between binding and activity

Journal of Biological Chemistry

Volumn 276, Issue 15, 2001, Pages 11552-11558

  Fawcett, Janet ^a   Hamel, Frederick G ^b,c   Bennett, Robert G ^b,c   Vajo, Zoltan ^a   Duckworth, William C ^a,d  

^a CARL T HAYDEN VA MEDICAL CENTER   (United States)

^b VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; ENZYME INHIBITION; INSULIN; PROTEINS; RADIOACTIVITY; SOLUBILITY;

INTRACELLULAR PROCESSING; PROTEIN DEGRADATION;

CELLS;

INSULIN; INSULIN DERIVATIVE; INSULIN LISPRO; INSULIN[B10 ASPARTIC ACID]; INSULIN[B4 GLUTAMINE B16 GLUTAMIC ACID B17 PHENYLALANINE]; PROTEASOME; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRAIN HEPG2; CELL TYPE; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; DRUG POTENCY; HORMONE ACTION; HORMONE BINDING; HORMONE RECEPTOR INTERACTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RADIOACTIVITY; RAT; ANIMAL; CELL CULTURE; DRUG EFFECT; HYDROLYSIS; LIVER CELL; LIVER TUMOR; METABOLISM; PATHOLOGY;

ANIMALIA;

ANIMALS; HEPATOCYTES; HYDROLYSIS; INSULIN; LIVER NEOPLASMS, EXPERIMENTAL; RATS; TUMOR CELLS, CULTURED;

EID: 0035853781     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007988200     Document Type: Article

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