M100907, a selective 5-HT2A receptor antagonist, attenuates phencyclidine-induced Fos expression in discrete regions of rat brain

European Journal of Pharmacology

Volumn 417, Issue 3, 2001, Pages 189-194

  Habara, Toshiaki ^a   Hamamura, Takashi ^a   Miki, Masahito ^a   Ohashi, Kazuyo ^a   Kuroda, Shigetoshi ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Antipsychotic; Atypical; Nucleus accumbens; Schizophrenia

Indexed keywords

ALPHA (2,3 DIMETHOXYPHENYL) 1 [2 (4 FLUOROPHENYL)ETHYL] 4 PIPERIDINEMETHANOL; NEUROLEPTIC AGENT; PHENCYCLIDINE; SEROTONIN 2A ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DRUG MECHANISM; IMMUNOREACTIVITY; LOCOMOTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCHIZOPHRENIA; SEPTUM NUCLEUS;

ANIMALS; BRAIN; FLUOROBENZENES; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MALE; ORGAN SPECIFICITY; PHENCYCLIDINE; PILOT PROJECTS; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-FOS; PSYCHOSES, SUBSTANCE-INDUCED; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT2A; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0035853396     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)00926-8     Document Type: Article

References (43)

1. Corticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine
2. Phencyclidine-induced psychosis
3. Clozapine. A novel antipsychotic agent
4. Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats
5. 2A receptor in the central nervous system of adult rat
6. The effects of antipsychotic drugs on Fos protein expression in the prefrontal cortex: Cellular localization and pharmacological characterization
7. The use of c-fos as a metabolic marker in neuronal pathway tracing
8. Effects of neuroleptics on phencyclidine (PCP)-induced locomotor stimulation in mice
9. Phencyclidine-induced locomotor activity in the rat is blocked by 6-hydroxydopamine lesion of the nucleus accumbens: Comparison to other psychomotor stimulants
10. Phencyclidine binding sites in the nucleus accumbens and phencyclidine-induced hyperactivity are decreased following lesions of the mesolimbic dopamine system
11. Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice
12. Phencyclidine (PCP) injected in the nucleus accumbens increases extracellular dopamine and serotonin as measured by microdialysis
13. Effect of phencyclidine on dopamine release in the rat prefrontal cortex; an in vivo microdialysis study
14. Recent advances in the phencyclidine model of schizophrenia
15. Preclinical characterization of the potential of the putative atypical antipsychotic MDL100,907 as a potent 5-HT2A antagonist with a favorable CNS safety profile
16. Understanding the mechanism of action of atypical antipsychotic drugs. A review of compounds in use and development
17. Clinical experience with risperidone
18. Blockade of phencyclidine-induced hyperlocomotion by clozapine and MDL 100,907 in rats reflects antagonism of 5-HT2A receptors
19. Clinical studies on the mechanism of action of clozapine: The dopamine-serotonin hypothesis of schizophrenia
20. The effects of clozapine, risperidone, and olanzapine on cognitive function in schizophrenia
21. Regional and cellular distribution of serotonin 5-hydroxytryptamine2a receptor mRNA in the nucleus accumbens, olfactory tubercle, and caudate putamen of the rat
22. 2A sites for PCP-induced locomotion in the rat
23. Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun
24. 2A antagonist
25. Effects of phencyclidine on immediate early gene expression in the brain
26. 1 agonist C-APB
27. 2C receptors
28. Expression of c-fos protein in brain: Metabolic mapping at the cellular level
29. Developmental changes in distribution patterns of phencyclidine-induced c-Fos in rat forebrain
30. 3 receptor agonist cis-8-OH-PBZI induces limbic Fos expression in rat brain
31. 2A receptor blockade
32. 2 receptors exert a state-dependent regulation of dopaminergic function: Studies with MDL100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine
33. 2A receptor antagonist for the treatment of schizophrenia
34. Phencyclidine (PCP) acts at sigma sites to induce c-fos gene expression
35. The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system
36. Phencyclidine abuse and symptomatic mania
37. 2 receptor antagonist MDL100907 as a putative atypical antipsychotic: Behavioral, electrophysiological and neurochemical studies
38. The behavioral and neurochemical effects of phencyclidine in humans and animals: Some implications for modeling psychosis
39. The role of nucleus accumbens dopamine in the neurochemical and behavioral effects of phencyclidine: A microdialysis and behavioral study
40. Phencyclidine increases extracellular dopamine metabolites in rat medial frontal cortex as measured by in vivo dialysis
41. 1 receptors in phencyclidine-induced behavioral stimulation in rats
42. Acute administration of typical and atypical antipsychotic drugs induces distinctive patterns of Fos expression in the rat forebrain