Effects of phencyclidine on immediate early gene expression in the brain

Journal of Neuroscience Research

Volumn 45, Issue 1, 1996, Pages 13-27

  Nakki R ^a,b,c   Sharp, F R ^a   Sagar, S M ^a   Honkaniemi, J ^a,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Alko Inc   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^d SAN FRANCISCO VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

neurotoxicity; NMDA antagonists; protooncogenes; zinc finger

Indexed keywords

MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENCYCLIDINE; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN TOXICITY; CINGULATE GYRUS; CONTROLLED STUDY; DRUG EFFECT; FOREBRAIN; GENE EXPRESSION; GENE INDUCTION; GRANULE CELL; HIPPOCAMPUS; IMMEDIATE EARLY GENE; IN SITU HYBRIDIZATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NEUROTOXICITY; NONHUMAN; ONCOGENE C FOS; ONCOGENE C JUN; PRIORITY JOURNAL; PROTO ONCOGENE; PURKINJE CELL; RAT;

ANIMALS; BRAIN CHEMISTRY; CEREBELLUM; EXCITATORY AMINO ACID ANTAGONISTS; GENE EXPRESSION REGULATION; GENES, IMMEDIATE-EARLY; IN SITU HYBRIDIZATION; MALE; OLIVARY NUCLEUS; PHENCYCLIDINE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 0029948335     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960701)45:1<13::AID-JNR2>3.0.CO;2-K     Document Type: Article

References (57)

1. Alldredge BK, Lowenstein DH, Simon RP (1989): Seizures associated with recreational drug abuse. Neurology 39:1037-1039.
2. Allen HL, Iversen LL (1990): Phencyclidine, dizocilpine, and cerebrocortical neurons. Science 247:221.
3. Ballarin M, Ernfors P, Lindefors N, Persson H (1991): Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Exp Neurol 114:35-43.
4. Chavrier P, Zerial M, Lemaire P, Almendral J, Bravo R, Charnay P (1988): A gene encoding a protein with zinc fingers is activated during G0/G1 transition in cultured cells. EMBO J 7:29-35.
5. Chen S-C, Curran T, Morgan JI (1995): Apoptosis in the nervous system: New revelations. J Clin Pathol 48:7-12.
6. Combs DJ, Dempsey RJ, Donaldson D, Kindy MS (1992): Hyperglycemia suppresses c-fos messenger RNA expression following transient cerebral ischemia in gerbils. J Cereb Blood Flow Metab 12:169-172.
7. Contreras PC, Contreras ML, O'Donohue TL, Lair CC (1988): Biochemical and behavioral effects of sigma and PCP ligands. Synapse 2:240-243.
8. Crosby SD, Puetz JJ, Simburger KS, Fahrner TJ, Milbrandt J (1991): The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family. Mol Cell Biol 11:3835-3841.
9. Curran T, Gordon MB, Rubino KL, Sambucetti LC (1987): Isolation and characterization of c-fos (rat) cDNA and analysis of posttranslational modification in vitro. Oncogene 2:79-84.
10. De Togni P, Niman H, Raymond V, Sawchenko P, Verma IM (1988): Detection of fos protein during osteogenesis by monoclonal antibodies. Mol Cell Biol 8:2251-2256.
11. Domino EF, Luby ED (1981): Abnormal mental states induced by phencyclidine as a model of schizophrenia. In Domino EF (ed): "PCP (Phencyclidine): Historical and Current Perspectives." Ann Arbor: NPP Books, pp 173-183.
12. Dragunow M, Young D, Hughes P, MacGibbon G, Lawlor P, Singleton K, Sirimanne E, Beilharz E, Gluckman P (1993): Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischemic brain injury? Mol Brain Res 18:347-352.
13. Ellison G (1995): The N-methyl-D-aspartate antagonists phencyclidine, ketamine and dizocilpine as both behavioral and anatomical models of the dementias. Brain Res Rev 20:250-267.
14. Fix AS, Horn JW, Wightman KA, Johnson CA, Long GO, Storts RW, Farber N, Wozniak DF, Oleny JW (1993): Neuronal vacuolization and necrosis induced by the non-competitive N-methyl-D-aspartate (NMDA) antagonist MK-801 (dizocilpine maleate): A light and electron microscopic evaluation of the rat retrosplenial cortex. Exp Neurol 123:204-215.
15. Gao XM, Shirakawa O, Du F, Tamminga CA (1993): Delayed regional metabolic actions of phencyclidine. Eur J Pharmacol 241:7-15.
16. Gao XM, Hashomoto T, Tamminga CA (1994): Time dependent changes in expression of immediate early genes in rat brain after phencyclidine. Soc Neurosci Abstr 20:732.
17. Gass P, Herdegen T, Bravo R, Kiessling M (1993): Induction and suppression of immediate early genes in specific rat brain regions by the non-competitive N-methyl-D-aspartate receptor antagonist MK-801. Neuroscience 53:749-758.
18. Gonzalez-Martin C, de Diego I, Crespo D, Fairen A (1992): Transient c-fos expression accompanies naturally occurring cell death in the developing interhemispheric cortex of the rat. Dev Brain Res 68:83-95.
19. Haas CA, Donath C, Kreutzberg GW (1993): Differential expression of immediate early genes after transection of the facial nerve. Neuroscience 53:91-99.
20. Hai T, Liu F, Coukos WJ, Green MR (1989): Transcription factor ATF cDNA clones: An extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers. Genes Dev 3:2083-2090.
21. Hazel TG, Nathans D, Lau LF (1988): A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc Natl Acad Sci USA 85:8444-8448.
22. Hengerer B, Lindholm D, Heumann R, Ruther U, Wagner EF, Thoenen H (1990): Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos. Proc Natl Acad Sci USA 87:3899-3903.
23. Honkaniemi J, Sagar SM, Pyykönen I, Hicks KJ, Sharp FR (1995): Focal brain injury induces multiple immediate early genes encoding zinc finger transcription factors. Mol Brain Res 28:157-163
24. Hughes P, Dragunow M (1995): Induction of immediate early genes and the control of neurotransmitter-regulated gene expression within the nervous system. Pharmacol Rev 47:133-178.
25. Hughes P, Dragunow M, Beilharz E, Lawlor P, Gluckman P (1993): MK801 induces immediate-early gene proteins and BDNF mRNA in rat cerebrocortical neurones. Neuroreport 4:183-186.
26. Javitt DC, Zukin SR (1991): Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 148:1301-1308.
27. Jenkins R, Hunt SP (1991): Long-term increase in the levels of c-jun mRNA and Jun protein-like immunoreactivity in motor and sensory neurons following axon damage. Neurosci Lett 129:107-110.
28. Junien JL, Leonard BE (1989): Drugs acting on a and phencyclidine receptors: A review of their nature, function and possible therapeutic importance. Clin Neuropharmacol 12:353-374.
29. Lanaud P, Maggio R, Gale K, Grayson D (1993): Temporal and spatial patterns of expression of c-fos, zif/268, c-jun, and jun-B mRNAs in rat brain following seizures evoked focally from the deep prepiriform cortex. Exp Neurol 119:20-31.
30. Lanteri-Minet M, Desmeules JA, Menetrey D (1993): Opposite effects of axon damage on heat shock proteins (hsp70) and ubiquitin content in motor neurons of neuropathic rats. Neurosci Lett 153:49-52.
31. Law SW, Conneely OM, Demayo FJ, O'Malley BW (1992): Identification of a new brain-specific transcription factor, NURR1. Mol Endocrinol 6:2129-2135.
32. Leah JD, Herdegen T, Bravo R (1991): Selective expression of JUN proteins following peripheral axotomy and axonal transport block in the rat: Evidence for a role in the regeneration process. Brain Res 566:198-207.
33. Leccese AP, Marquis KL, Mattia A, Moreton JE (1986): The convulsant and anticonvulsant effects of phencyclidine (PCP) and PCP analogues in the rat. Behav Brain Res 19:163-169.
34. Liu J, Nickolenko J, Sharp FR (1994): Morphine induces c-fos and junB in striatum and nucleus accumbens via D, and N-methyl-D-aspartate receptors. Proc Natl Acad Sci USA 91:8537-8541.
35. Lodge D, Johnson KM (1990): Noncompetitive excitatory amino acid receptor antagonists. Trends Pharmacol Sci 11:81-86.
36. Milbrandt J (1987): A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 238:797-799.
37. Moochetti I, De Bernardi MA, Szekely AM, Alho H, Brooker G, Costa E (1989): Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma cells: A potential role of c-fos protein. Proc Natl Acad Sci USA 86:3891-3895.
38. Näkki R, Koistinaho J, Sharp FR, Sagar SM (1995): Cerebellar toxicity of phencyclidine. J Neurosci 15:2097-2108.
39. Näkki R, Sharp FR, Sagar SM (1996): Fos expression in the brainstem and cerebellum following phencyclidine and MK801. J Neurosci Res 43:203-212.
40. Ogawa S, Okuyama S, Araki H, Nakazato A, Otomo S (1994): A rat model of phencyclidine psychosis. Life Sci 55:1605-1610.
41. Olney JW, Labruyere J, Price MT (1989): Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244:1360-1362.
42. Olney JW, Labruyere J, Wang G, Wozniak DF, Price MT, Sesma MA (1991): NMDA antagonist neurotoxicity: Mechanism and prevention. Science 254:1515-1518.
43. Patwardhan S, Gashler A, Siegel MG, Chang LC, Joseph LJ, Shows TB, Lebeau MM (1991): EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene 6:917-928.
44. Paxinos G, Watson C (1986): "The Rat Brain in Stereotaxic Coordinates," 2nd ed. New York: Academic Press.
45. Reynolds IJ, Miller RJ (1990): Allosteric modulation of N-methyl-D-aspartate receptors. Adv Pharmacol 21:101-126.
46. Robinson GA (1995): Axotomy-induced regulation of c-Jun expression in regenerating rat retinal ganglion cells. Mol Brain Res 30:61-69.
47. Ryseck RP, Hirai SI, Yaniv M, Bravo R (1988): Transcriptional activation of c-jun during the G0/G1 transition in mouse fibroblasts. Nature 334:535-537.
48. Saffen DW, Cole AJ, Worley PF, Christy BA, Ryder K, Baraban JM (1988): Convulsant-induced increase in transcription factor messenger RNAs in rat brain. Proc Natl Acad Sci USA 85:7795-7799.
49. Sagar SM, Sharp FR (1993): Early response genes as markers of neuronal activity and growth factor action. Adv Neurol 59:273-284.
50. Sagar SM, Sharp FR, Curran T (1988): Expression of c-fos protein in brain: Metabolic mapping at the cellular level. Science 240:1328-1331.
51. Seiler N, Grauffel C (1992): Antagonism of phencyclidine-induced hyperactivity in mice by elevated brain GABA concentrations. Pharmacol Biochem Behav 41:603-606.
52. 14C) 2-deoxyglucose uptake in the caudal cerebellum of the rat during motor/sensory cortex stimulation. J Comp Neural 284:621-636.
53. Sharp FR, Jasper P, Hall J, Noble L, Sagar SM (1991): MK-801 and ketamine induce heat shock protein HSP70 in injured neurons in posterior cingulate and retrosplenial cortex. Ann Neurol 30:801-809.
54. Sharp FR, Butman M, Wang S, Koistinaho J, Graham SH, Sagar SM, Noble L, Berger P, Longo FM (1992): Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine. J Neurosci Res 33:605-616.
55. Sheng M, Greenberg ME (1990): The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4:477-485.
56. Smeyne RJ, Vendrell M, Hayward M, Baker SJ, Miao GG, Schilling K, Robertson LM, Curran T, Morgan JI (1993): Continuous c-fos expression precedes programmed cell death in vivo. Nature 363:166-169.
57. Worley PF, Christy BA, Nakabeppu Y, Bhat RV, Cole AJ, Baraban JM (1991): Constitutive expression of zif268 in neocortex is regulated by synaptic activity. Proc Natl Acad Sci USA 88:5106-5110.