Selective vulnerability of the developing brain to lead

Current Opinion in Neurology

Volumn 11, Issue 6, 1998, Pages 689-693

  Johnston, Michael V ^a   Goldstein, Gary W ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR; LEAD; NEUROTRANSMITTER; PROTEIN KINASE C;

BRAIN DEVELOPMENT; BRAIN FUNCTION; ENVIRONMENTAL EXPOSURE; HUMAN; INTELLIGENCE; NEUROTRANSMISSION; NEUROTRANSMITTER RELEASE; POSTNATAL DEVELOPMENT; REVIEW; SIGNAL NOISE RATIO; SYNAPTIC TRANSMISSION;

ADOLESCENT; ADULT; ANIMALS; BRAIN DAMAGE, CHRONIC; CEREBRAL CORTEX; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INTELLIGENCE; LEAD; LEAD POISONING; MALE; PREGNANCY; SYNAPTIC TRANSMISSION;

EID: 0031798230     PISSN: 13507540     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019052-199812000-00013     Document Type: Review

References (36)

1. Goldstein GW. Neurologic concepts of lead poisoning in children. Pediatr Ann 1992; 21:384-388.
2. Goldstein GW. Brain capillaries: a target for inorganic lead poisoning. Neurotoxicology 1984; 5:167-175.
3. Bressler JP, Goldstein GW. Mechanisms of lead neurotoxicity. Biochem Pharmacol 1991; 41:479-484.
4. Needleman HL, Schell A, Bellinger D, Leviton A, Aired EN. The long-term effects of exposure to low doses of lead in childhood. New Engl J Med 1990; 322:83-88. An outstanding clinical study documenting the somewhat controversial point that early lead exposure in children lowers IQ in a linear, dose related fashion.
5. Manalis RS, Cooper GP. Presynaptic and postsynaptic effects of lead at the frog neuromuscular junction. Nature 1973; 243:354-355.
6. Minnema DJ, Michaelson IA, Cooper GP. Calcium efflux and neurotransmitter release from rat hippocampal synaptosomes exposed to lead. Toxicol Appl Pharmacol 1988; 84:400-411.
7. Alkondon M, Costa ACS, Radhakrishnan V, Aronstam RS, Albuquerque EX. Selective blockade of NMDA-activated channel currents may be implicated in learning deficits caused by lead. FEBS Lett 1990; 261:124-130.
8. Alfano DP, Petit TL. Neonatal lead exposure alters the dendritic development of hippocampal dentate granule cells. Exp Neurol 1982; 75:275-288.
9. Pocock G, Simons TJB. Effects of lead ions on events associated with exocytosis in isolated bovine adrenal medullary cells. J Neurochem 1987; 48:376-382.
10. Yi EY, Lim, DK. Effects of chronic lead exposure on glutamate release and uptake in cerebellar cells of rat pups. Arch Pharm Res 1998; 21:113-119.
11. McDonald JW, Johnston MV. Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res Rev 1990; 15:41-70.
12. Nicoll RA, Malenka RC. Contrasting properties of two forms of long term potentiation in the hippocampus. Nature 1995; 377:115-118.
13. Ishihara K, Alkondon M, Montes JG, Albuquerque EX. Ontogenically related properties of NMDA receptors in rat hippocampal neurons and the age-specific sensitivity of developing neurons to lead. J Pharm Exp Ther 1995; 273:1459-1470.
14. Sheng M, Cummings J, Roulau LA. Changing subunit composition of herteromeric NMDA receptors during development of rat cortex. Nature 1994; 368:144-147.
15. Burgard EC, Hablitz JJ. Developmental changes in NMDA and non-NMDA receptor mediated synaptic potentials in rat neocortex. J Neurophysiol 1993; 69:230-240.
16. •] demonstrate one of the molecular reasons for the special vulnerability of the immature brain to lead toxicity.
17. Omelchenko IA, Nelson CS, Allen CN. Lead inhibition of NMDA receptors containing NR2A, NR2C and NR2D subunits. J PET 1997; 282:1458-1464.
18. Guilarte TR, McGlothan JL. Hippocampal NMDA receptor mRNA undergoes subunit specific changes during developmental lead exposure. Brain Res 1998; 790:98-107.
19. Guilarte TR, Miceli RC, Jett DA. Neurochemical aspects of hippocampal and cortical Pb neurotoxicity. Neurotoxicology 1994; 15:459-466.
20. Gilbert ME, Mack CM, Lasley SM. Chronic developmental lead exposure increases threshold for long-term potentiation in the rat dentate gyrus in vivo. Brain Res 1996; 736:118-124.
21. Gilbert ME, Mack CM. Chronic lead exposure accelerates decay of long-term potentiation in rat dentate gyrus in vivo. Brain Res 1998; 789:139-149.
22. Cory-Slechta DA. Postnatal lead exposure and MK-801 sensitivity. Neurotoxicology 1997; 18:209-220.
23. Petit TL, LeBoutillier JC, Brooks WJ. Altered sensitivity to NMDA following developmental lead exposure in rats. Physiol Behav 1992; 52:687-693.
24. Cory-Slechta DA, Flaugher CL, Evans SB, Pokora MJ, Greenamyre, JT. Susceptibility of adult rats to lead-induced changes in NMDA receptor complex function. Neurotoxicol Teratol 1997; 19:517-530.
25. Cory-Slechta DA. Relationships between Pb-induced changes in neurotransmitter system function and behavioral toxicity. Neurotoxicology 1997; 18:673-688.
26. Brockel BJ, Cory-Slechta DA. Lead, attention, and impulsive behavior: changes in fixed-ratio waiting-for-reward paradigm. Pharmacol Biochem Behav 1998; 60:545-552. A good synthesis of the possible relevance of basic science animal studies to cognitive-behavioral disorders in children who have been exposed to lead.
27. Cory-Slechta DA, O'Mara DJ, Brockel BJ. Nucleus accumbens dopaminergic medication of fixed interval schedule-controlled behavior and its modulation by low-level lead exposure. J PET 1998; 286:794-805.
28. Cory-Slechta DA, McCoy L, Richfield EK. Time course and regional basis of Pb-induced changes in MK-801 binding: reversal by chronic treatment with the dopamine agonist apomorphine but not the D1 agonist SKF-82958. J Neurochem 1997; 68:2012-2023.
29. Markovac J, Goldstein GW. Picomolar concentrations of lead stimulate protein kinase C. Nature 1988; 334:71-73.
30. Routtenberg A. Synaptic plasticity and protein kinase C. Progr Brain Res 1986; 69:211-234.
31. Kim K, Annadata M, Goldstein GW, Bressler JP. Induction of c-fos mRNA by lead in PC-12 cells. Int J Dev Neurosci 1997; 15:175-182.
32. Schoepp DD. The biochemical pharmacology of metabotropic glutamate receptors. Biochem Soc Trans 1993; 21:97-102.
33. Bear MF, Dudek SM. Stimulation of phosphoinositide turnover by excitatory amino acids. Pharmacology, development and role in visual cortical plasticity. Ann NY Acad Sci 1991; 627:42-56.
34. Blue ME, Martin LJ, Brennan EM, Johnston MV. Ontogeny of non-NMDA glutamate receptors in rat barrel field cortex. I. Metabotropic receptors. J Comp Neurol 1997; 386:16-28.
35. Huttenlocher PR, deCourten C. The development of synapses in striate cortex of man. Human Neurobiol 1987; 6:1-9. A pioneering study of synaptic density in human cortex, showing the overshoot and pruning in synapse number in cortex during human postnatal development.
36. Rabacchi S, Bailly Y, Delhaye-Bouchard N. Involvement of NMDA receptors in synapse elimination during cerebellar development. Science 1992; 256:1823-1825.