Nasal administration of cholera toxin (CT) suppresses clinical signs of experimental autoimmune encephalomyelitis (EAE)

Vaccine

Volumn 20, Issue 1-2, 2001, Pages 134-139

  Yura, Mamoru ^a   Takahashi, Ichiro ^a   Terawaki, Seigo ^a   Hiroi, Takachika ^a   Kweon, Mi Na ^a   Yuki, Yoshikazu ^b   Kiyono, Hiroshi ^a  

^a OSAKA UNIVERSITY   (Japan)

^b JCR Biopharmaceuticals Inc   (United States)

Author keywords

Cholera toxin (CT); Experimental autoimmune encephalomyelitis (EAE); Nasal administration

Indexed keywords

CD4 ANTIGEN; CHOLERA TOXIN; GAMMA INTERFERON; IMMUNOMODULATING AGENT; INTERLEUKIN 12; MYELIN OLIGODENDROCYTE GLYCOPROTEIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CELL SPECIFICITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HELPER CELL; IMMUNOMODULATION; INFECTION PREVENTION; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TH1 CELL; VIBRIO CHOLERAE;

ADJUVANTS, IMMUNOLOGIC; ADMINISTRATION, INTRANASAL; AMINO ACID SEQUENCE; ANIMALS; AUTOIMMUNE DISEASES; CENTRAL NERVOUS SYSTEM; CHOLERA TOXIN; DRUG EVALUATION, PRECLINICAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; GLYCOPROTEINS; HUMANS; INTERFERON TYPE II; INTERLEUKIN-12; MICE; MICE, INBRED C57BL; PEPTIDE FRAGMENTS; SEVERITY OF ILLNESS INDEX; SPLEEN; TH1 CELLS; TH2 CELLS;

EID: 0035851002     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00278-X     Document Type: Article

References (46)

1. The immunology of multiple sclerosis and its animal model, experimental allergic encephalomyelitis
2. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain
3. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
4. An altered peptide ligand mediates immune deviation and prevents autoimmune encephalomyelitis
5. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
6. Suppression of acute and protracted-relapsing experimental allergic encephalomyelitis by nasal administration of low-dose IL-10 in rats
7. Nasal administration of transforming growth factor-β1 induces dendritic cells and inhibits protracted-relapsing experimental allergic encephalomyelitis
8. The complexicity of cytokine treatment in ongoing EAE induced with MBP peptide 68-86 in Lewis rats
9. IFN-γ plays a critical down-regulatory role in the induction and effector phase of myelin oligodendrocyte glycoprotein-induced autoimmune encephalomyelitis
10. TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination
11. Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease
12. Interleukin-10 prevents experimental allergic encephalomyelitis in rats
13. Cytokines and murine autoimmune encephalomyelitis: Inhibition or enhancement of disease with antibodies to select cytokines, or by delivery of exogenous cytokines using a recombinant vaccinia virus system
14. IL-10 fails to abrogate experimental autoimmune encephalomyelitis
15. Interaction of cholera toxin and toxin derivatives with lymphocytes. Part I. Binding properties and interference with lectin-induced cellular stimulation
16. Gangliosides and membrane receptors for cholera toxin
17. Dissociation and recombination of the subunits of the cholera enterotoxin (choleragen)
18. Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli
19. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin
20. Cholera toxin B subunit: An efficient transmucosal carrier-delivery system for induction of peripheral immunological tolerance
21. Treatment of experimental autoimmune encephalomyelitis by feeding myelin basic protein conjugated to cholera toxin B subunit
22. Helper T cell subsets for immunoglobulin A responses: Oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues
23. Mucosal adjuvant effect of cholera toxin in mice results from induction of T helper 2 (Th2) cells and IL-4
24. Structure and polymorphism of the mouse myelin/oligodendrocyte glycoprotein gene
25. A critical role for lymphotoxin in experimental allergic encephalomyelitis
26. + T cell cytokine profile in experimental allergic encephalomyelitis
27. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery
28. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice
29. A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice
30. Acceleration of experimental autoimmune encephalomyelitis in interleukin-10-deficient mice: Roles of interleukin-10 in disease progression and recovery
31. Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: Fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production
32. Comparison of nasal and oral tolerance for the prevention of collagen-induced murine arthritis
33. Suppression of ongoing experimental allergic encephalomyelitis (EAE) in Lewis rats: Synergistic effects of myelin basic protein (MBP) peptide 68-86 and IL-4
34. Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor β1 and β2 chain expression
35. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection
36. Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
37. Anti-IL-12 antibody prevents the development and progression of multiple sclerosis-like relapsing-remitting demyelinating disease in NOD mice induced with myelin oligodendrocyte glycoprotein peptide
38. Cutting edge: The mucosal adjuvant cholera toxin redirects vaccine proteins into olfactory tissues
39. Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin
40. Microglia are more efficient than astrocytes in antigen processing and in Th1 but not Th2 cell activation
41. Cytokines in inflammatory brain lesions: Helpful and harmful
42. Chemokines in neurological disease models: Correlation between chemokine expression patterns and inflammatory pathology
43. Microglia as effector cells in brain damage and repair: Focus on prostanoids and nitric oxide
44. Enhancing effect of cholera toxin on interleukin-6 secretion by IEC-6 intestinal epithelial cells: Mode of action and augmenting effect of inflammatory cytokines
45. Mechanisms of IL-10 production in human microglia-T cell interaction
46. A non-toxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity