Control of a genetic regulatory network by a selector gene

Science

Volumn 292, Issue 5519, 2001, Pages 1164-1167

  Guss, Kirsten A ^a   Nelson, Craig E ^a   Hudson, Angela ^a   Kraus, Mary Ellen ^a   Carroll, Sean B ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GENETIC ENGINEERING; INTEGRATION; PROTEINS; SIGNALING;

GENETIC REGULATORY NETWORKS;

GENES;

DNA BINDING PROTEIN; TRANSCRIPTION FACTOR;

ARTICLE; BINDING SITE; DROSOPHILA; FORELIMB; GENE CONTROL; GENE FUNCTION; GENETIC REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BASE SEQUENCE; BINDING SITES; DNA; DNA FOOTPRINTING; DNA-BINDING PROTEINS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, INSECT; GENES, REPORTER; LARVA; MODELS, GENETIC; MUTATION; ORGAN SPECIFICITY; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; WING;

EID: 0035844087     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1058312     Document Type: Article

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39. We thank D. Nellen for identifying and providing the sal 328-bp element and transgenic flies;. S. Blair, K. Irvine, R. Schuh, and J. Jack for providing fruit fly stocks; T. Stone and J. Posakony for SU(H) protein; A. Laughon for MAD protein and probes; D. Dorsett for cut sequence and DNA; V. Kassner, J. Selegue, and K. Vacarro for invaluable technical assistance; L. Olds for figure preparation; J. Carroll for manuscript preparation; M. Levine for helpful discussion; and A. Kopp, G. Panganiban, and T. Wittkopp for comments on the manuscript. J. Magee initiated the studies of SD site mutations in the vg Q enhancer, and J.-Y. Sgro and the Institute for Molecular Virology provided access to GCG. Supported by NIH postdoctoral fellowships to K.A.G. and M.E.K., and the Howard Hughes Medical Institute, of which S.B.C. is an Investigator.