The p38 SAPK pathway regulates the expression of the MMP-9 collagenase via AP-1-dependent promoter activation

Experimental Cell Research

Volumn 271, Issue 2, 2001, Pages 344-355

  Simon, Christian ^a   Simon, Matthias ^b   Vucelic, Goran ^a   Hicks, M John ^c   Plinkert, Peter Karl ^a   Koitschev, Assen ^a   Zenner, Hans Peter ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

AP 1; Cancer invasion; MMP 9; p38

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; COLLAGENASE; GELATINASE B; GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C JUN; PROTEINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CANCER CELL; CANCER INVASION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE MUTATION; HUMAN; HUMAN CELL; NONHUMAN; ONCOGENE; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

EID: 0035842316     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5374     Document Type: Article

References (61)

1. The biochemistry of cancer dissemination
2. PD 098059, an inhibitor of ERK1 activation, attenuates the in vivo invasiveness of head and neck squamous cell carcinoma
3. Gelatinolytic activity of matrix metalloproteinase in tumor tissues correlates with the invasiveness of oral cancer
4. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: The potential for multiplex signalling
5. Regulation of 92 kDa type 4 collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades
6. Stimulation of 92-kDa gelatinase B promoter activity by ras is mitogen-activated protein kinase kinase-1-independent and requires multiple transcription factor binding sites including closely spaced PEA3/ets and AP-1 sequences
7. Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells
8. Hepatocyte growth factor upregulates E1AF that induces oral squamous cell carcinoma cell invasion by activating matrix metalloproteinase genes
9. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
10. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)
11. The primary structure ofp38γ: A new member of p38 group of MAP kinases
12. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase
13. Selective activation of p38α and p38γ by hypoxia
14. ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation
15. Characterization of the structure and function of a novel MAP kinase kinase (MKK6)
16. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
17. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6
18. Inhibition of the p38 mitogen-activated protein kinase by SB 203580 blocks PMA-induced Mr 92,000 type collagenase secretion and in vitro invasion
19. AP-1: One switch for many signals
20. A requirement for exytracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum
21. v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines
22. Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase
23. alpha B-crystallin gene induction and phosphorylation by MKK6-activated p38. A potential role for alpha B-crystallin as a target of the p38 branch of the cardiac stress response
24. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
25. T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38. and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A
26. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest
27. Urokinase plasminogen activator/urokinase-specific surface receptor expression and matrix invasion by breast cancer cells requires constitutive p38alpha mitogen-activated protein kinase activity
28. A role for the p38 mitogen-activated protein kinase pathway in myocardial cell growth, sarcomeric organization, and cardiac-specific gene expression
29. The jun proto-oncogene is positively autoregulated by its product, Jun/ AP-1
30. Effect of PD 098059, a specific inhibitor of mitogen-activated protein kinase kinase, on urokinase expression and in vitro invasion
31. Interleukin-1 beta and transforming growth factor-alpha/epidermal growth factor induce expression of M(r) 95,000 type IV collagenase/gelatinase and interstitial fibroblast-type collagenase by rat mucosal keratinocytes
32. Sustained activation of the mitogen-activated protein kinase pathway. A mechanism underlying receptor tyrosine kinase specificity for matrix metalloproteinase-9 induction and cell migration
33. Regulation of matrix metalloproteinase expression in tumor invasion
34. Sustained ERK phosphorylation is necessary but not sufficient for MMP-9 regulation in endothelial cells: Involvement of Ras-dependent and -independent pathways
35. KISS-1 represses 92 kDa type IV collagenase expression by down-regulating NF-kappa B binding to the promoter as a consequence of I kappa B alpha-induced block of p65/p50 nuclear translocation
36. Amplification of IL-1 beta-induced matrix metalloproteinase-9 expression by superoxide in rat glomerular mesangial cells is mediated by increased activities of NF-kappaB and activating protein-1 and involves activation of the mitogen-activated protein kinase pathways
37. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta
38. Identification and characterization of a predominant isoform of human MKK3
39. Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta)
40. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase
41. Stress-induced immediate-early gene, egr-1, involves activation of p38/JNK1
42. Effect of 1-beta-D-arabinofuranosylcytosine on apoptosis and ifferentiation in human monocytic leukemia cells (U937) expressing a c-Jun dominant-negative mutant protein (TAM67)
43. Novel homologues of CSBP/p38 MAP kinase: Activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles
44. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
45. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor
46. The role of proteolytic enzymes in cancer invasion and metastasis
47. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages
48. Growth regulation via p38 mitogen-activated protein kinase in developing liver
49. MKK6 activates myocardial cell NF-kB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner
50. Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest
51. alpha B-crystallin gene induction and phosphorylation by MKK6-activated p38. A potential role for alpha B-crystallin as a target of the p38 branch of the cardiac stress response
52. Regulation by p38 mitogen-activated protein kinase of adenylate- and uridylate-rich element-mediated urokinase-type plasminogen activator (uPA) messenger RNA stability and uPA-dependent in vitro cell invasion
53. Regulation of urokinase-type plasminogen activator expression in squamous-cell carcinoma of the oral cavity
54. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
55. DNA alkylation-induced phosphorylation of p53 and activation of kinases in colon cancer cells
56. Fibroblast growth factor receptor signaling activates the human interstitial collagenase promoter via the bipartite Ets-Ap1 element
57. Matrix metalloproteinases and the development of cancer
58. Matrix metalloproteinases: Biological activity and clinical implications
59. Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase
60. Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch
61. Increased stromolysin 3 gene expression is associated with increased local invasiveness in head and neck squamous cell carcinomas