Highly selective and potent neuropeptide Y (NPY) Y1 receptor antagonists based on [Pro30, Tyr32, Leu34]NPY(28-36)-NH2 (BW1911U90)

Journal of Medicinal Chemistry

Volumn 44, Issue 10, 2001, Pages 1479-1482

  Balasubramaniam, A ^a   Dhawan, V C ^a   Mullins, D E ^a   Chance, W T ^a   Sheriff, S ^a   Guzzi, M ^a   Prabhakaran, M ^a   Parker, E M ^a  

^a Div of Gastrointestinal Hormones   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BW 1911U90; GR 231118; ISOLEUCYLASPARTYLPROLYLISOLEUCYLTYROSYLARGINYLTYROSINAMIDE; J 104870; N [1 [4 [[[[4 [(DIMETHYLAMINO)METHYL]CYCLOHEXYL]METHYL]AMINO]IMINOMETHYL]BENZYL] 2 OXO 2 (1 PYRROLIDINYL)ETHYL] ALPHA [(2 NAPHTHALENYLSULFONYL)AMINO]BENZENEPROPANAMIDE; N2 DIPHENYLACETYL N (4 UREIDOMETHYLBENZYL)ARGININAMIDE; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE [28-36]; NEUROPEPTIDE Y [28-36][30 PROLINE 32 TYROSINE 34 LEUCINE]; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y1 RECEPTOR; T 190; T 241; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; BINDING AFFINITY; CONTROLLED STUDY; DIABETES MELLITUS; DIMERIZATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HYPERTENSION; LETTER; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN SYNTHESIS; RECEPTOR BLOCKING; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEIZURE; STRUCTURE ACTIVITY RELATION;

ANIMALS; CELL LINE; CLONING, MOLECULAR; CYCLIC AMP; EATING; HUMANS; OLIGOPEPTIDES; RATS; RECEPTORS, NEUROPEPTIDE Y; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035837061     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010031k     Document Type: Letter

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