Crystal structure of the liganded SCP-2-like domain of human peroxisomal multifunctional enzyme type 2 at 1.75 Å resolution

Journal of Molecular Biology

Volumn 313, Issue 5, 2001, Pages 1127-1138

  Haapalainen, Antti M ^a   Van Aalten, Daan M F ^b   Meriläinen, Gitte ^a   Jalonen, Jorma E ^a   Pirilä, Päivi ^a   Wierenga, Rik K ^a   Hiltunen, J Kalervo ^a   Glumoff, Tuomo ^a  

^a UNIVERSITY OF OULU   (Finland)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Multifunctional enzyme; Peroxisome; Sterol; Triton X 100; oxidation

Indexed keywords

ACYL COENZYME A; LIGAND; MULTIFUNCTIONAL ENZYME 2; REGULATOR PROTEIN; STEROL CARRIER PROTEIN 2; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME STRUCTURE; FATTY ACID OXIDATION; HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

MAMMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0035834530     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2001.5084     Document Type: Article

References (52)

1. Peroxisomal β-oxidation and polyunsaturated fatty acids
2. Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein
3. Molecular cloning and amino acid sequence of the porcine 17 β-estradiol dehydrogenase
4. Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: Medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase
5. β-Oxidation -strategies for the metabolism of a wide variety of acyl-CoA esters
6. Further characterization of the peroxisomal 3-hydroxyacyl-CoA dehydrogenases from rat liver. Relationship between the different dehydrogenases and evidence that fatty acids and the C27 bile acids di- and tri-hydroxycoprostanic acids are metabolized by separate multifunctional proteins
7. Peroxisomal multifunctional enzyme of β-oxidation metabolizing D-3-hydroxyacyl-CoA esters in rat liver: Molecular cloning, expression and characterization
8. Porcine 80-kDa protein reveals intrinsic 17β-hydroxysteroid dehydrogenase, fatty acyl-CoA-hydratase/dehydrogen acyl-CoA-hydratase/dehydrogenase, and sterol transfer activities
9. Unique multifunctional HSD17B4 gene product: 17β-hydroxysteroid dehydrogenase 4 and D-3-hydroxyacylcoenzyme A dehydrogenase/hydratase involved in Zellweger syndrome
10. Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids
11. Peroxisomal multifunctional β-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product
12. Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: Role of the hydratase reaction in bile acid synthesis
13. The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein
14. A novel peroxisomal nonspecific lipid-transfer protein from Candida tropicalis. Gene structure, purification and possible role in β-oxidation
15. Molecular cloning of hSLP-1, a novel human brain-specific member of the band 7/MEC-2 family similar to Caenorhabditis elegans UNC-24
16. Protein translocation into peroxisomes
17. Identification of Pex13p a peroxisomal membrane receptor for the PTS1 recognition factor
18. The structure of the human sterol carrier protein X/sterol carrier protein 2 gene (SCP2)
19. Structure of the gene for the human 17β-hydroxysteroid dehydrogenase type IV
20. Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function
21. Sterol carrier protein 2: A role in steroid hormone synthesis?
22. Sterol carrier protein-2 is involved in cholesterol transfer from the endoplasmic reticulum to the plasma membrane in human fibroblasts
23. FRET microscopy demonstrates molecular association of non-specific lipid transfer protein (nsL-TP) with fatty acid oxidation enzymes in peroxisomes
24. Structure of sterol carrier protein 2 at 1.8 Å resolution reveals a hydrophobic tunnel suitable for lipid binding
25. NMR structure of the sterol carrier protein-2: Implications for the biological role
26. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
27. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice
28. Molecular characterization of GmFOX2, an evolutionarily highly conserved gene from the mycorrhizal fungus Glomus mosseae, down-regulated during interaction with rhizobacteria
29. Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
30. SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
31. Barley lipid-transfer protein complexed with palmitoyl CoA: The structure reveals a hydrophobic binding site that can expand to fit both large and small lipid-like ligands
32. Crystal structure of FadR, a fatty acid-responsive transcription factor with a novel acyl coenzyme A-binding fold
33. The three-dimensional structure of acyl-coenzyme A binding protein from bovine liver: Structural refinement using heteronuclear multidimensional NMR spectroscopy
34. Automated analysis of interatomic contacts in proteins
35. WHAT IF: A molecular modeling and drug design program
36. High-affinity binding of very-long-chain fatty acyl-CoA esters to the peroxisomal non-specific lipid-transfer protein (sterol carrier prorein-2)
37. Sterol carrier protein-2, a new fatty acyl coenzyme A-binding protein
38. The crystal structure of enoyl-CoA hydratase complexed with octanoyl-CoA reveals the structural adaptations required for binding of a long chain fatty acid-CoA molecule
39. The SH3 domain of the Saccharomyces cerevisiae peroxisomal membrane protein Pex13p functions as a docking site for Pex5p, a mobile receptor for the import PTS1-containing proteins
40. Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways
41. The crystal structure of dienoyl-CoA isomerase at 1.5 Å resolution reveals the importance of aspartate and glutamate sidechains for catalysis
42. Structure-activity studies of human sterol carrier protein 2
43. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
44. Sparse matrix sampling: Screening method for crystallization of proteins
45. Processing of X-ray diffraction data collected in oscillation mode
46. Solvent content of crystals
47. AMoRe: An automated package for molecular replacement
48. Crystallography & NMR system: A new software system for macromolecular structure determination
49. Automated protein model building combined with iterative structure refinement
50. PROCHECK: A program to check the stereochemical quality of protein structures
51. 1-(1,1,3,3-tetramethyl)butyl-4phenyl-1,2,4-triazoline-3,5-dione