NMR structure of the sterol carrier protein-2: Implications for the biological role

Journal of Molecular Biology

Volumn 295, Issue 3, 2000, Pages 595-603

  García, Francisco López ^a   Szyperski, Thomas ^a   Dyer, James H ^a   Choinowski, Thomas ^a   Seedorf, Udo ^b   Hauser, Helmut ^a   Wüthrich, Kurt ^a  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Nitroxide spin labels; NMR; Protein dynamics; Protein structure; Sterol carrier protein 2

Indexed keywords

STEROL CARRIER PROTEIN 2;

ARTICLE; CARBOXY TERMINAL SEQUENCE; HUMAN; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LIPID INTERACTION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

EID: 0034695426     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3355     Document Type: Article

References (35)

1. The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein
2. The program XEASY for computer-supported NMR spectral analysis of biological macro-molecules
3. The Protein Data Bank: A computer-based archival file for macromolecular structures
4. Rat liver proteins capable of transferring phosphatidylethanolamine. Purification and transfer activity for other phospholipids and cholesterol
5. Aromatic-aromatic interaction: A mechanism of protein structure stabilization
6. 13C-separated rotating frame Overhauser spectroscopy
7. Phytanic acid activates the peroxisome poliferator-activated receptor α (PPARα) in sterol carrier protein 2-/sterol carrier protein x-deficient mice
8. 15N NMR relaxation
9. Torsion angle dynamics for NMR structure calculation with the new program DYANA
10. Conformational analysis of protein and nucleic acid fragments with the new grid search algorithm FOUND
11. The FSSP database of structurally aligned protein fold families
12. Measurements of molecular electrostatic field effects in edge-to-face aromatic interactions and CH-π interactions with implications for protein folding and molecular recognition
13. MOLMOL: A program for display and analysis of macromolecular structures
14. Spin labeling of proteins
15. Porcine 80-kDa protein reveals intrinsic 17β-hydroxysteroid dehy-drogenase, fatty acyl-CoA-hydratase/dehydrogenase, and sterol transfer activities
16. Peroxisome proliferator-activated receptors: A nuclear receptor signaling pathway in lipid physiology
17. The new program OPAL for molecular dynamics simulations and energy refinements of biological macromolecules
18. cDNA sequence and bacterial expression of mouse liver sterol carrier protein 2
19. 13C labeling
20. Chicken sterol carrier protein 2/sterol carrier protein X: cDNA cloning reveals evolutionary conservation of structure and regulated expression
21. The anatomy and taxonomy of protein structure
22. Probing the ligand binding sites of fatty acid and sterol carrier proteins: Effects of ethanol
23. Cloning, expression and nucleotide sequence of rat liver sterol carrier protein 2 cDNAs
24. Structure-activity studies of human sterol carrier protein-2
25. Sterol carrier protein-X is peroxisomal 3-oxoacyl-coenzyme A thiolase with intrinsic sterol carrier and phosphatidylcholine transfer activity
26. Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function
27. 13C labelling
28. The sterol carrier protein 2 fatty acid binding site: An NMR, circular dichroic, and fluorescence spectroscopic determination
29. Determination of scalar coupling constants by inverse Fourier transformation of in-phase multiplets
30. 15N spin relaxation times
31. NMR determination of the secondary structure and the three-dimensional polypeptide backbone fold of the human sterol carrier protein 2
32. In pre-sterol carrier protein 2 (SCP2) in solution the leader peptide 1-20 is flexibly disordered, and residues 21-143 adopt the same globular fold as in mature SCP2
33. Cloning and expression of a cDNA encoding human sterol carrier protein 2