KF31327, a new potent and selective inhibitor of cyclic nucleotide phosphodiesterase 5

European Journal of Pharmacology

Volumn 431, Issue 1, 2001, Pages 17-24

  Hirose, Ryo ^a   Okumura, Hiroshi ^a   Yoshimatsu, Akiko ^a   Irie, Junko ^a   Onoda, Yasuo ^a   Nomoto, Yuji ^a   Takai, Haruki ^a   Ohno, Tetsuji ^a   Ichimura, Michio ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

cAMP; cGMP; KF31327 (3 ethyl 8 2 (4 hydroxymethylpiperidino)benzylamino 2,3 dihydro 1H imidazo 4,5 g quinazoline 2 thione dihydrochloride); Phosphodiesterase 5 (cyclic GMP specific phosphodiesterase); Platelet; Sildenafil

Indexed keywords

3 ETHYL 8 [2 (4 HYDROXYMETHYLPIPERIDINO)BENZYLAMINO] 2,3 DIHYDRO 1H IMIDAZO[4,5 G]QUINAZOLINE 2 THIONE; COLLAGEN; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; GLYCERYL TRINITRATE; KF 31327; PHOSPHODIESTERASE INHIBITOR; SILDENAFIL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL LEVEL; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; TRACHEA;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ANIMALS; BLOOD PLATELETS; CYCLIC AMP; CYCLIC GMP; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; ISOENZYMES; KINETICS; MOLECULAR STRUCTURE; NITROGLYCERIN; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PIPERAZINES; PLATELET AGGREGATION INHIBITORS; QUINAZOLINES; RABBITS;

EID: 0035834482     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01422-4     Document Type: Article

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