Synthesis and biological evaluation of tropane-like 1-{2-[bis(4-fluorophenyl)methoxy]ethyl})-4-(3-phenylpropyl)piperazine (GBR 12909) analogues

Journal of Medicinal Chemistry

Volumn 44, Issue 23, 2001, Pages 3937-3945

  Zhang, Y ^a,b   Joseph, D B ^a,c   Bowen, W D ^a   Flippen Anderson, J L ^d   Dersch, C M ^e   Rothman, R B ^e   Jacobson, A E ^a   Rice, K C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b ARQULE INC   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^d NAVAL RESEARCH LABORATORY   (United States)

^e NIDA Addiction Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 BENZYHYDRYLOXYETHYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCTANE; 3 [2 [BIS (4 FLUOROPHENYL)METHOXY]ETHYL] 8 METHYL 8 AZABICYCLO[3.2.1]OCTANE; 3 [2 [BIS (4 FLUOROPHENYL)METHOXY]ETHYLIDENE] 8 METHYL 8 AZABICYCLO[3.2.1]OCTANE; BENZATROPINE; DOPAMINE TRANSPORTER; N [BIS(4 FLUOROPHENYL)METHYL] 2 (8 METHYL 8 AZABICYCLO[3.2.1]OCT 3 YL)ACETAMIDE; TROPANE DERIVATIVE; UNCLASSIFIED DRUG; VANOXERINE;

ARTICLE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; RECEPTOR AFFINITY; X RAY CRYSTALLOGRAPHY;

ANIMALS; BRAIN; CARRIER PROTEINS; CRYSTALLOGRAPHY, X-RAY; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M1; RECEPTORS, MUSCARINIC; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TROPANES;

EID: 0035829440     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0101592     Document Type: Article

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