Synthesis and transporter binding properties of bridged piperazine analogues of 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine (GBR 12909)

Journal of Medicinal Chemistry

Volumn 43, Issue 25, 2000, Pages 4840-4849

  Zhang, Y ^a,c   Rothman, R B ^b   Dersch, C M ^b   De Costa, B R ^a,d   Jacobson, A E ^a   Rice, K C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NIDA Addiction Research Center   (United States)

^c ARQULE INC   (United States)

^d HOSPITAL OF SAINT RAPHAEL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (BENZHYDRYLOXY)ETHYL] 4 (3 PHENYLALLYL)PIPERAZINE; 1 [2 (BENZHYDRYLOXY)ETHYL] 4 (3 PHENYLPROPYL)PIPERAZINE; BRIDGED COMPOUND; DOPAMINE; DOPAMINE TRANSPORTER; PIPERAZINE DERIVATIVE; SEROTONIN TRANSPORTER; VANOXERINE;

ARTICLE; BINDING AFFINITY; DOPAMINE UPTAKE; DRUG PROTEIN BINDING; DRUG SYNTHESIS; DRUG TRANSPORT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; CARRIER PROTEINS; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; HETEROCYCLIC COMPOUNDS, BRIDGED-RING; INDOLES; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PIPERAZINES; RADIOLIGAND ASSAY; RATS; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES;

EID: 0034649563     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000300r     Document Type: Article

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