메뉴 건너뛰기




Volumn 301, Issue 4, 2000, Pages 759-767

Crystal structure of dengue virus NS3 protease in complex with a bowman-birk inhibitor: Implications for flaviviral polyprotein processing and drug design

Author keywords

Bowman Birk inhibitor; Conformational change; Dengue virus; Drug design; Substrate recognition

Indexed keywords

ANTINEOPLASTIC AGENT; BOWMAN BIRK INHIBITOR; PROTEINASE INHIBITOR; SERINE PROTEINASE; VIRUS ENZYME; VIRUS PROTEIN;

EID: 0034714111     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3924     Document Type: Article
Times cited : (91)

References (46)
  • 5
    • 0008032001 scopus 로고
    • XPLOR Manual, Yale University, New Haven, CT
    • (1990)
    • Brunger, A.T.1
  • 6
    • 0026597444 scopus 로고
    • Free R value: A novel statistical quantity for assessing the accuracy of crystal structures
    • (1992) Nature , vol.355 , pp. 472-474
    • Brunger, A.T.1
  • 11
    • 4244096575 scopus 로고
    • Studied on the mung bean trypsin inhibitor
    • Proteins in Biology and Medicine (Bradshaw, R. A., Liamg, C. C., Hill, R. L., Tsao, T. C., Tang, J. and Tsou, C. L., eds), Academic Press, New York
    • (1982) , pp. 427-456
    • Chi, C.W.1    Lo, S.S.2    Tan, F.L.3    Zhamg, Y.S.4    Chu, H.M.5
  • 12
    • 0002583957 scopus 로고
    • 'dm': An automated procedure for phase improvement by density modification
    • Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography (Bailey, S., ed.) vol. 31, Daresbury Laboratory, Warrington
    • (1994) , pp. 34-38
    • Cowtan, K.1
  • 13
    • 0031573474 scopus 로고    scopus 로고
    • Complex of leech derived tryptase inhibitor (Ldti) with trypsin and modeling of the Ldti-tryptase system
    • (1997) Structure , vol.5 , pp. 1465-1474
    • DiMarco, S.1    Priestle, J.P.2
  • 15
    • 0027499688 scopus 로고
    • Deletion analysis of dengue virus type 4 nonstructural protein NS2B: Identification of a domain required for NS2B-NS3 protease activity
    • (1993) J. Virol. , vol.67 , pp. 2034-2042
    • Falgout, B.1    Miller, R.H.2    Lai, C.-J.3
  • 20
    • 0000946759 scopus 로고
    • Bowman-Birk family serine proteinase inhibitors
    • The Proteases (Barrett, A. J. S. and Salvesan, R., ed.), Academic Press, New York
    • (1986)
    • Ikenaka, T.1    Norioka, S.2
  • 25
    • 0033605260 scopus 로고    scopus 로고
    • Dengue virus NS3 serine protease: Crystal structure and insights into interaction of the active site with substrates by molecular modeling and structural analysis of mutational effects
    • (1999) J. Biol. Chem. , vol.274 , pp. 5573-5580
    • Murthy, H.M.K.1    Clum, S.2    Padmanabhan, R.3
  • 34
    • 0005930158 scopus 로고
    • Isomorphous Replacement and Anomalous Scattering (Wolf, W., Evans, P. R. and Leslie, A. G. W., eds), Daresbury Laboratory, Warrington
    • (1991) , pp. 101-107
    • Otwinowski, Z.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.