Leflunomide's bioactive metabolite has the minimal structural requirements for the efficient inhibition of human dihydroorotate dehydrogenase

Bioorganic Chemistry

Volumn 25, Issue 4, 1997, Pages 233-238

  Papageorgiou, Christos ^a   Zurini, M ^a   Weber, Hans Peter ^b   Borer, Xaver ^a  

^a Preclinical Research   (Switzerland)

^b Nova Research Services   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROOROTATE DEHYDROGENASE; LEFLUNOMIDE;

ARTICLE; DRUG STRUCTURE; ENZYME INHIBITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; STRUCTURE ANALYSIS;

EID: 0031205910     PISSN: 00452068     EISSN: None     Source Type: Journal    
DOI: 10.1006/bioo.1997.1072     Document Type: Article

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