Quantitative autoradiographic mapping of the ORL1, μ-, δ- and κ-receptors in the brains of knockout mice lacking the ORL1 receptor gene

Brain Research

Volumn 906, Issue 1-2, 2001, Pages 13-24

  Clarke, Siân ^a   Chen, Zhengping ^b   Hsu, Ming Sing ^b   Pintar, John ^b   Hill, Ray ^c   Kitchen, Ian ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Autoradiography; Knockout mouse; Nociceptin orphanin FQ; Opioid receptor; ORL1 knockout; ORL1 receptor

Indexed keywords

DELTA OPIATE RECEPTOR; DELTORPHIN; ENADOLINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; KAPPA OPIATE RECEPTOR; MU OPIATE RECEPTOR; NOCICEPTIN; OPIATE RECEPTOR; OPIOID RECEPTOR LIKE ONE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; GENE DELETION; GENE MAPPING; GENOTYPE; KNOCKOUT MOUSE; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR GENE;

ANALGESICS, OPIOID; ANIMALS; AUTORADIOGRAPHY; BENZOFURANS; BINDING SITES; BRAIN; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; GENE DELETION; MICE; MICE, KNOCKOUT; NEURONS; NEUROPROTECTIVE AGENTS; OLIGOPEPTIDES; OPIOID PEPTIDES; PYRROLIDINES; RADIOLIGAND ASSAY; RECEPTORS, OPIOID; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, KAPPA; RECEPTORS, OPIOID, MU; TRITIUM;

EID: 0035816369     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)02531-8     Document Type: Article

References (51)

1. 3H] TIPP
2. Distribution of the nociceptin and nocistatin precursor transcript in the mouse central nervous system
3. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type
4. Molecular cloning, tissue distribution and chromosomal loclaization of a novel member of the opioid receptor gene family
5. Molecular cloning and functional expression of a μ-opioid receptor from rat brain
6. The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion
7. Model systems for the study of seven-transmembrane-segment receptors
8. Cloning of a delta opioid receptor by functional expression
9. 3H]nociceptin binding sites from telencephalic to mesencephalic regions of the mouse brain
10. 3H] nociceptin binding sites in the rat brain
11. 14]Orphanin binding to rat brain: Evidence for labelling the opioid-receptor-like 1 (ORL1)
12. cDNA cloning and regional distribution of a novel member of the opioid receptor family
13. Nociceptin differentially affects morphine-induced dopamine release from the nucleus accumbens and the nucleus caudate in rats
14. Orphanin FQ, a novel neuropeptide with anti-stress-like activity
15. Memory retrieval enhancement by kappa opioid agonist and mu, delta antagonists
16. Orphanin FQ acts as an anxiolytic to attenuate behavioral responses to stress
17. The δ-opioid receptor: Isolation of cDNA by expression cloning and pharmacological characterization
18. Quantitative autoradiographic mapping of μ-, δ- and κ-opioid receptors in knockout mice lacking the μ-opioid receptor gene
19. Drugs of abuse: Anatomy, pharmacology and function of reward pathways
20. Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family
21. Central cardiovascular effects of κ agonists dynorphin-(1-13) and ethylketocyclazocine in the anaethetized rat
22. Stress-induced parallel changes in central opioid levels and pain responsiveness in the rat
23. Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice
24. Facilitation of long-term potentiation and memory in mice lacking nocicptin receptors
25. Autoradiographic differentiation of mu, delta and kappa opioid receptors in the rat forebrain and midbrain
26. Biochemical evidence for orphanin FQ/Nociceptin receptor heterogeneity in mouse brain
27. 1 receptor
28. Orphanin FQ is a functional anti-opioid peptide
29. ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization
30. Orphanin FQ/nociceptin block acquisition of morphine place preference
31. Orphanin FQ/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis
32. 14Tyr] -orphanin FQ binding
33. Localization of orphanin FQ (Nociceptin) peptide and messenger RNA in the central nervous system of the rat
34. Nociceptin stimulates food intake and hyperpolarises neurones in the rat ventromedial hypothalamus
35. Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor
36. Structure and chromosomal mapping of genes for the mouse κ-opioid receptor and an opioid receptor homologue (MOR-C)
37. Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice
38. Enkephalins as immunomodulators
39. Orphanin FQ: A neuropeptide that activates an opioid like G protein-coupled receptor
40. Nociceptin/Orphanin FQ microinjected into hippocampus impairs spatial learning in rats
41. 1 opioid receptors in κ-opioid receptor knockout mice
42. Injections of nociceptin into nucleus accumbens shell or ventromedial hypothalamic nucleus increase food intake
43. Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence
44. Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene
45. Effects of juvenile isolation and morphine treatment on social interactions and opioid receptors in adult rats: Behavioural and autoradiographic studies
46. cDNA cloning of an orphan opiate receptor gene family member and its splice variant
47. Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ, and κ opioid receptors
48. An alternatively spliced transcript of the rat nociceptin receptor ORL1 gene encodes a truncated receptor
49. Nociceptin or antinociceptin: Potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat
50. Cloning and functional comparison of κ and δ opioid receptors from mouse brain