Effects of juvenile isolation and morphine treatment on social interactions and opioid receptors in adult rats: Behavioural and autoradiographic studies

European Journal of Neuroscience

Volumn 11, Issue 9, 1999, Pages 3023-3032

  Van Den Berg, Caroline L ^a,b   Van Ree, Jan M ^a   Spruijt, Berry M ^a   Kitchen, Ian ^b  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Autoradiography; Juvenile isolation; Opioid receptors ( , and ); Social interaction test; 3H CI 977; 3H DAMGO; 3H DELT I

Indexed keywords

DELTA OPIATE RECEPTOR; EPSILON OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR; MORPHINE; MU OPIATE RECEPTOR; OPIATE RECEPTOR;

AMYGDALOID NUCLEUS; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BEHAVIOR MODIFICATION; BINDING SITE; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SOCIAL INTERACTION; SOCIAL ISOLATION; STRIA TERMINALIS; SUBSTANTIA NIGRA;

EID: 0032863103     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.1999.00717.x     Document Type: Article

References (62)

1. Adler, M.W., Bendotti, C., Ghezzi, D., Samanin, R. & Valzelli, L. (1975) Dependence to morphine in differentially housed rats. Psychopharmacologia (Berl.), 41, 15-18.
2. Baenninger, L.P. (1967) Comparison of behavioural development in socially isolated and grouped rats. Anim. Behav., 15, 312-323.
3. Beatty, W.W. & Costello, K.B. (1982) Naloxone and play fighting in juvenile rats. Pharmacol. Biochem. Behav., 17, 905-907.
4. Bekoff, M. (1976) The social deprivation paradigm: who's being deprived of what ? Dev. Psychobiol., 9, 499-500.
5. Benton, D. & Brain, P.F. (1988) The role of opioid mechanisms in social interaction and attachment. In Rodgers, R.J. &. Cooper, S.J. (eds), Endorphins, Opiates and Behavioural Processes. John Wiley & Sons Ltd, New York, pp. 217-235.
6. Bolles, R.C. & Woods, P.J. (1964) The ontogeny of behaviour in the albino rat. Anim. Behav., 12, 427-441.
7. Bonnet, K.A., Hiller, J.M. & Simon, E.J. (1976) The effects of chronic opiate treatment and social isolation on opiate receptors in the rodent brain. In Kosterlitz, H.W. (ed.), Opiates and Endogenous Opioid Peptides. Elsevier/ North-Holland Biomedical Press, Amsterdam, pp. 335-343.
8. Calcagnetti, D.J. & Schechter, M.D. (1992) Place conditioning reveals the rewarding aspect of social interaction in juvenile rats. Physiol. Behav., 51, 667-672.
9. De Cabo, C., Kelly, M., Kitchen, I. & Viveros, P. (1992) Effects of neonatal sexual isolation on μ-receptor development and nociceptive responses in the rat. Neurosci. Res. Comm., 10, 79-86.
10. 2]Deltorphin-I: a high affinity, delta-selective opioid receptor ligand. Peptides, 12, 825-830.
11. File, S.E. & Rodgers, R.J. (1979) Partial anxiolytic action of morphine sulphate following microinjection into the central nucleus of the amygdala in rats. Pharmacol. Biochem. Behav., 11, 313-318.
12. Fox, M.W. & Stelzner, D. (1966) Behavioural effects of differential early experience in the dog. Anim. Behav., 14, 273-281.
13. Gerall, A.A. (1963) An exploratory study of the effect of social isolation variables on the sexual behaviour of male guinea pigs. Anim. Behav., 11, 274-282.
14. Gerall, H.D., Ward, I.L. & Gerall, A.A. (1967) Disruption of the male rat's sexual behaviour induced by social isolation. Anim. Behav., 15, 54-58.
15. Gruendel, A.D. & Arnold, W.J. (1969) Effects of early social deprivation on reproductive behavior of male rats. J. Comp. Physiol. Psychol., 67, 123-128.
16. Hol, T., Niesink, R.J.M., Van Ree, J.M. & Spruijt, B.M. (1996a) Prenatal exposure to morphine affects juvenile play behavior and adult social behavior in rats. Pharmacol. Biochem. Behav., 55, 615-618.
17. Hol, T., Ruven, S., van Ree, J.M. & Spruijt, B.M. (1996b) Chronic administration of Org2766 and morphine counteracts isolation-induced increase in social interest: implication of endogenous opioid systems. Neuropeptides, 30, 283-291.
18. Hol, T. & Spruijt, B.M. (1992) The MSH/ACTH (4-9) analog Org2766 counteracts isolation-induced enhanced social behavior via the amygdala. Peptides, 13, 541-544.
19. Hol, T., Van den Berg, C.L., Van Ree, J.M. & Spruijt, B.M. (1999) Isolation during the play period in infancy decreases adult social interactions in rats. Behav. Brain Res., 100, 91-97.
20. Humphreys, A.P. & Einon, D.F. (1981) Play as a reinforcer for maze-learning in juvenile rats. Anim. Behav., 29, 259-270.
21. Jackson, A. & Cooper, S.J. (1986) An observational analysis of the effect of the selective kappa opioid agonist, U-50,488H, on feeding and related behaviours in the rat. Psychopharmacology (Berl.), 90, 217-221.
22. Jalowiec, J.E., Calcagnetti, D.J. & Fanselow, M.S. (1989) Suppression of juvenile social behavior requires antagonism of central opioid systems. Pharmacol. Biochem. Behav., 33, 697-700.
23. 3H]-CI-977 reveal early development of κ-opioid sites in rat brain. Mol. Neuropharmacol., 2, 269-272.
24. Kitchen, I., Leslie, F.M., Kelly, M., Barnes, R., Crook, T.J., Hill, R.G., Borsodi, A., Toth, G., Melchiorri, P. & Negri, L. (1995) Development of delta-opioid receptor subtypes and the regulatory role of weaning: radioligand binding, autoradiography and in situ hybridization studies. J. Pharmacol. Exp. Ther., 275, 1597-1607.
25. Kitchen, I., Slowe, S.J., Matthes, H.W.D. & Kieffer, B. (1997) Quantitative autoradiographic mapping of μ-, δ- and κ-opioid receptors in knockout mice lacking the μ-opioid receptor gene. Brain Res., 778, 73-88.
26. Kostowski, W., Czlonkowski, A., Rewerski, W. & Piechocki, T. (1977) Morphine action in grouped and isolated rats and mice. Psychopharmacology, 53, 191-193.
27. Lahti, R.A. & Collins, R.J. (1978) Chronic naloxone results in prolonged increases in opiate binding sites in brain. Eur. J. Pharmacol., 51, 185-186.
28. Latané, B., Nesbitt, P., Eckman, J. & Rodin, J. (1972) Long-and short-term social deprivation and sociability in rats. J. Comp. Physiol. Psychol., 81, 69-75.
29. Lore, R. & Flannelly, K. (1977) Rat societies. Sci. Am., 236, 106-116.
30. Lore, R.K. & Stipo-Flaherty, A. (1988) Postweaning social experience and adult aggression in rats. Physiol. Behav., 33, 571-574.
31. Mansour, A., Khachaturian, H., Lewis, M.E., Akil, H. & Watson, S.J. (1987) Autoradiographic differentiation of mu, delta, and kappa opioid receptors in the rat forebrain and midbrain. J. Neurosci., 7, 2445-2464.
32. Matthes, H.W.D., Maldonado, R., Simonin, F., Valverde, O., Slowe, S., Kitchen, I., Befort, K., Dierich, A., Le Meur, M., Dolle, P., Tzavara, E., Hanoune, J., Roques, B.P. & Kieffer, B.L. (1996) Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking μ-opioid-receptor gene. Nature, 383, 819-823.
33. Meaney, M.J. & Stewart, J. (1979) Environmental factors influencing the affilitiative behavior of male and female rats (Rattus norvegicus). Anim. Learn. Behav., 7, 397-405.
34. Niesink, R.J.M. & van Ree, J.M. (1982) Short-term isolation increases social interactions of male rats: a parametric analysis. Physiol. Behav., 29, 819-825.
35. Niesink, R.J.M. & Van Ree, J.M. (1983) Normalizing effect of an adrenocortcotropic hormone (4-9) analog ORG 2766 on disturbed social behavior in rats. Science, 221, 960-962.
36. Niesink, R.J.M. & van Ree, J.M. (1989) Involvement of opioid and dopaminergic systems in isolation-induced pinning and social grooming of young rats. Neuropharmacology, 28, 411-418.
37. Niesink, R.J.M., Vanderschuren, L.J.M.J. & Van Ree, J.M. (1996) Social play in juvenile rats after in utero exposure to morphine. Neurotoxicology, 17, 905-912.
38. Normansell, L. & Panksepp, J. (1990) Effects of morphine and naloxone on play-rewarded spatial discrimination in juvenile rats. Dev. Psychobiol., 23, 75-83.
39. Panksepp, J. (1980) Brief social isolation, pain responsivity, and morphine analgesia in young rats. Psychopharmacology, 72, 111-112.
40. Panksepp, J. & Bishop, P. (1981) An autoradiographic map of [3H]diprenorphine binding in rat brain: effects of social interaction. Brain Res. Bull., 7, 405-410.
41. Panksepp, J., Herman, B.H., Vilberg, T., Bishop, P. & DeEskinazi, F.G. (1980) Endogenous opioids and social behavior. Neurosci. Biobehav. Rev., 4, 473-487.
42. Panksepp, J., Jalowiec, J., DeEskinazi, F.G. & Bishop, P. (1985) Opiates and play dominance in juvenile rats. Behav. Neurosci., 99, 441-453.
43. Panksepp, J., Najam, N. & Soares, F. (1979) Morphine reduces social cohesion in rats. Pharmacol. Biochem. Behav., 11, 131-134.
44. Paxinos, G. & Watson, C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, Sydney.
45. Petkov, V.V., Konstantinova, E. & Grachovska, T. (1985) Changes in brain opiate receptors in rats with isolation syndrome. Pharmacol. Res. Comm., 17, 575-584.
46. Ridd, M.J., Fosbraey, P. & Kitchen, I. (1998) The effect of acute kainic acid treatment on μ-opioid receptors in rat brain. Brain Res., 814, 26-33.
47. 5]enkephalin: further evidence for two μ-binding sites. Eur. J. Pharmacol., 160, 71-82.
48. Schenk, S., Britt, M.D., Atalay, J. & Charleson, S. (1982) Isolation rearing decreases opiate receptor binding in rat brain. Pharmacol. Biochem. Behav., 16, 841-842.
49. Scott, J.P. (1962) Critical periods in behavioral development. Science, 138, 949-958.
50. Sharif, N.A. & Hughes, J. (1989) Discrete mapping of brain mu and delta opioid receptors using selective peptides: quantitative autoradiography, species differences and comparison with kappa receptors. Peptides, 10, 499-522.
51. Siegel, M.A. & Jensen, R.A. (1986) The effects of naloxone and cage size on social play and activity in isolated young rats. Behav. Neural Biol., 45, 155-168.
52. Siviy, S.M. (1998) Neurobiological substrates of play behavior: glimpes into the structure and function of mammalian playfuness. In Bekoff, M. &. Byers, J.A. (eds), Animal Play: Evolutionary, Comparative, and Ecological Perspectives. Cambridge University Press, Cambridge, pp. 221-242.
53. Spruijt, B.M., Van Hooff, J.A.R.A.M. & Gispen, W.H. (1992) The ethology and neurobiology of grooming behaviour. Physiol. Rev., 72, 825-852.
54. Suomi, S.J., Harlow, H.F. & Novak, M.A. (1974) Reversal of social deficits produced by isolation rearing in monkeys. J. Hum. Evol., 3, 527-534.
55. Thor, D.H. & Holloway, W.R. (1984) Social play in juvenile rats: a decade of methodological and experimental research. Neurosci. Biobehav. Rev., 8, 455-464.
56. Van den Berg, C.L., Hol, T., Everts, H., Koolhaas, J.M., Van Ree, J.M. & Spruijt, B.M. (1999) Play is indispensable for an adequate development of coping with social challenges in the rat. Dev. Psychobiol., 34, 129-138.
57. Van Ree, J.M. & Niesink, R.J.M. (1983) Low doses of β-endorphin increase social contact of rats tested in dyadic encounters. Life Sci., 33, 611-614.
58. Vanderschuren, L.J.M.J., Niesink, R.J.M., Spruijt, B.M. & van Ree, J.M. (1995a) Mu- and kappa-opioid receptor-mediated opioid effects on social play in juvenile rats. Eur. J. Pharmacol., 276, 257-266.
59. Vanderschuren, L.J.M.J., Niesink, R.J.M., Spruijt, B.M. & van Ree, J.M. (1995b) Effects of morphine on different aspects of social play in juvenile rats. Psychopharmacology, 117, 225-231.
60. Vanderschuren, L.J.M.J., Niesink, R.J.M. & van Ree, J.M. (1997) The neurobiology of social play behavior in rats. Neurosci. Biobehav. Rev., 21, 309-326.
61. Vanderschuren, L.J.M.J., Stein, E.A., Wiegant, V.M. & van Ree, J.M. (1995c) Social play alters regional brain opioid receptor binding in juvenile rats. Brain Res., 680, 148-156.
62. Wolterink, G. & Van Ree, J.M. (1989) Opioid systems in the amygdala can serve as substrate for the behavioral effects of the ACTH (4-9) analog ORG 2766. Neuropeptides, 14, 129-136.