An alternatively spliced transcript of the rat nociceptin receptor ORL1 gene encodes a truncated receptor

Molecular Brain Research

Volumn 77, Issue 1, 2000, Pages 1-9

  Xie, Guo xi ^a   Ito, Emi ^a   Maruyama, Kazuo ^b   Pietruck, Christian ^a   Sharma, Manohar ^a   Yu, Long Chuan ^a   Pierce Palmer, Pamela ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Alternative splicing; Genomic sequence; Nociceptin; Opioid; Orphanin FQ; Receptor

Indexed keywords

AMINO ACID; COMPLEMENTARY DNA; CYCLIC AMP; NOCICEPTIN; NOCICEPTIN RECEPTOR; OPIATE RECEPTOR;

ALTERNATIVE RNA SPLICING; ARTICLE; DNA SEQUENCE; GENETIC TRANSCRIPTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN STRUCTURE; RAT; TRANSPOSON;

ALTERNATIVE SPLICING; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BRAIN; COS CELLS; INTRONS; KINETICS; LIVER; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OPIOID PEPTIDES; PROTEIN ISOFORMS; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, OPIOID; RECOMBINANT PROTEINS; RNA, MESSENGER; SEQUENCE ALIGNMENT; SEQUENCE DELETION; SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION, GENETIC; TRANSFECTION;

MAMMALIA;

EID: 0034646780     PISSN: 0169328X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-328X(00)00033-4     Document Type: Article

References (33)

1. Anton B., Fein J., To T., Li X., Silberstein L., Evans C.J. Immunohistochemical localization of ORL-1 in the central nervous system of the rat. J. Comp. Neurol. 368:1996;229-251.
2. Bunzow J.R., Saez C., Mortrud M., Bouvier C., Williams J.T., Low M., Grandy D.K. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type. FEBS Lett. 347:1994;284-288.
3. Capeyrou R., Riond J., Corbani M., Lepage J.F., Bertin B., Emorine L.J. Agonist-induced signaling and trafficking of the mu-opioid receptor: role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain. FEBS Lett. 415:1997;200-205.
4. Chan J.S., Yung L.Y., Lee J.W., Wu Y.L., Pei G., Wong Y.H. Pertussis toxin-insensitive signaling of the ORL1 receptor: coupling to Gz and G16 proteins. J. Neurochem. 71:1998;2203-2210.
5. Cohen J.B., Broz S.D., Levinson A.D. Expression of H-ras proto-oncogene is controlled by alternative splicing. Cell. 58:1989;461-472.
6. Kummer W., Fischer A. Nociceptin and its receptor in guinea pig sympathetic ganglia. Neurosci. Lett. 234:1997;35-38.
7. Lapalu S., Moisand C., Butour J.L., Mollereau C., Meunier J.C. Different domains of the ORL1 and kappa-opioid receptors are involved in recognition of nociceptin and dynorphin A. FEBS Lett. 427:1998;296-300.
8. Mamiya T., Noda Y., Nishi M., Takeshima H., Nabeshima T. Enhancement of spatial attention in nociceptin/orphanin FQ receptor-knockout mice. Brain Res. 783:1998;236-240.
9. Manabe T., Noda Y., Mamiya T., Katagiri H., Houtani T., Nishi M., Noda T., Takahashi T., Sugimoto T., Nabeshima T., Takeshima H. Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors. Nature. 394:1998;577-581.
10. Maruyama K., Takebe Y. New trend of cDNA cloning. Med. Immunol. (Tokyo). 20:1990;27-32.
11. McKeown M. Alternative mRNA splicing. Annu. Rev. Cell Biol. 8:1992;133-155.
12. Meng F., Hoversten M.T., Thompson R.C., Taylor L., Watson S.J., Akil H. A chimeric study of the molecular basis of affinity and selectivity of the kappa and the delta opioid receptors. Potential role of extracellular domains. J. Biol. Chem. 270:1995;12730-12736.
13. Meng F., Taylor L.P., Hoversten M.T., Ueda Y., Ardati A., Reinscheid R.K., Monsma F.J., Watson S.J., Civelli O., Akil H. Moving from the orphanin FQ receptor to an opioid receptor using four point mutations. J. Biol. Chem. 271:1996;32016-32020.
14. Meunier J.-C. Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor. Eur. J. Pharmacol. 340:1997;1-15.
15. Meunier J.-C., Moliereau C., Toll L., Suaudeau C., Moisand C., Alvinerie P., Butour J.-L., Guillemot J.-C., Ferrara P., Monsarrat B., Mazarguli H., Vassart G., Parmentier M., Costentin J. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature. 377:1995;532-535.
16. Mollereau C., Mouledous L., Lapalu S., Cambois G., Moisand C., Butour J.L., Meunier J.C. Distinct mechanisms for activation of the opioid receptor-like 1 and kappa-opioid receptors by nociceptin and dynorphin A. Mol. Pharmacol. 55:1999;324-331.
17. Mollereau C., Parmentier M., Mailleux P., Butour J.L., Moisand C., Chalon P., Caput D., Vassart G., Meunier J.C. ORL1, a novel member of the opioid receptor family: cloning, functional expression and localization. FEBS Lett. 341:1994;33-38.
18. Monteillet-Agius G., Fein J., Anton B., Evans C.J. ORL-1 and mu opioid receptor antisera label different fibers in areas involved in pain processing. J. Comp. Neurol. 399:1998;373-383.
19. 14]-orphanin FQ binding. J. Comp. Neurol. 412:1999;563-605.
20. Nishi M., Houtani T., Noda Y., Mamiya T., Sato K., Doi T., Kuno J., Takeshima H., Nukada T., Nabeshima T., Yamashita T., Noda T., Sugimoto T. Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphanin FQ receptor. EMBO J. 16:1997;1858-1864.
21. Noda Y., Mamiya T., Nabeshima T., Nishi M., Higashioka M., Takeshima H. Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice. J. Biol. Chem. 273:1998;18047-18051.
22. Pan Y.X., Xu J., Pasternak G.W. Structure and characterization of the gene encoding a mouse kappa3-related opioid receptor. Gene. 171:1996;255-260.
23. Pan Y.X., Xu J., Wan B.L., Zuckerman A., Pasternak G.W. Identification and differential regional expression of KOR-3/ORL-1 gene splice variants in mouse brain. FEBS Lett. 435:1998;65-68.
24. Peluso J., LaForge K.S., Matthes H.W., Kreek M.J., Kieffer B.L., Gaveriaux-Ruff C. Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells. J. Neuroimmunol. 81:1998;184-192.
25. Reinscheid R.K., Ardati A., Monsma F.J. Jr., Civelli O. Structure-activity relationship studies on the novel neuropeptide orphanin FQ. J. Biol. Chem. 271:1996;14163-14168.
26. Reinscheid R.K., Nothacker H.-P., Bourson A., Ardati A., Henningsen R.A., Bunzow J.R., Grandy D.K., Langen H., Monsma F.J. Jr., Civelli O. Orphanin FQ: a neuropeptide that activates an opioid-like G protein-coupled receptor. Science. 270:1995;792-794.
27. Topham C.M., Mouledous L., Poda G., Maigret B., Meunier J.C. Molecular modeling of the ORL1 receptor and its complex with nociceptin. Protein Eng. 11:1998;1163-1179.
28. Ueda H., Yamaguchi T., Tokuyama S., Inoue M., Nishi M., Takeshima H. Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene. Neurosci. Lett. 237:1997;136-138.
29. Varga E.V., Li X., Stropova D., Zalewska T., Landsman R.S., Knapp R.J., Malatynska E., Kawai K., Mizusura A., Nagase H., Calderon S.N., Rice K., Hruby V.J., Roeske W.R., Yamamura H.I. The third extracellular loop of the human delta-opioid receptor determines the selectivity of delta-opioid agonists. Mol. Pharmacol. 50:1996;1619-1624.
30. Wang J.B., Johnson P.S., Imai Y., Persico A.M., Ozenberger B.A., Eppler C.M., Uhl G.R. cDNA cloning of an orphan opiate receptor gene family member and its splice variant. FEBS Lett. 348:1994;75-79.
31. Wick M.J., Minnerath S.R., Roy S., Ramakrishnan R., Loh H.H. Expression of alternate forms of brain opioid 'orphan' receptor mRNA in activated human peripheral blood lymphocytes and lymphocyte cell lines. Mol. Brain Res. 32:1995;342-347.
32. Xie G.X., Maruyama K., Miyajima A. Construction of mammalian brain size-fractionated cDNA expression library and expression cloning of neuropeptide receptor by ligand binding. Neurosci. Protocols. 2:1995;1-17.
33. Xie G.X., Meuser T., Pietruck C., Sharma M., Pierce Palmer P. Presence of opioid receptor-like (ORL1) receptor mRNA splice variants in peripheral sensory and sympathetic neuronal ganglia. Life Sci. 64:1999;2029-2037.