Effects of CP-99, 994, a tachykinin NK1 receptor antagonist, on abdominal afferent vagal activity in ferrets: Evidence for involvement of NK1 and 5-HT3 receptors

European Journal of Pharmacology

Volumn 428, Issue 2, 2001, Pages 215-220

  Minami, M ^a   Endo, T ^a   Yokota, H ^a   Ogawa, T ^a   Nemoto, M ^a   Hamaue, N ^a   Hirafuji, M ^a   Yoshioka, M ^b   Nagahisa, A ^c   Andrews, P L R ^d  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c PFIZER INC   (United States)

^d ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Abdominal afferent nerve activity; Antiemetic activity; CP 100, 263; CP 99, 994; Granisetron; Substance P; Tachykinin NK1 receptor antagonist

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; CISPLATIN; EMETIC AGENT; GRANISETRON; NEUROKININ 1 RECEPTOR; SEROTONIN; SEROTONIN 3 RECEPTOR; SUBSTANCE P; TACHYKININ RECEPTOR ANTAGONIST;

ABDOMEN; ANIMAL EXPERIMENT; ANTIEMETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FERRET; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; SENSORY NERVE; SEROTONIN RELEASE; VAGUS NERVE STIMULATION;

ABDOMEN; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FERRETS; GRANISETRON; INJECTIONS, INTRAVENOUS; MALE; PIPERIDINES; RECEPTORS, NEUROKININ-1; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN; SEROTONIN ANTAGONISTS; STEREOISOMERISM; SUBSTANCE P; VAGUS NERVE;

EID: 0035812617     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(01)01297-3     Document Type: Article

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