The effect of the NK1 receptor antagonist CP-99,994 on emesis and c-fos protein induction by loperamide in the ferret

Neuropharmacology

Volumn 39, Issue 2, 2000, Pages 316-323

  Zaman, S ^a   Woods, A J ^a   Watson, J W ^b   Reynolds, D J M ^c   Andrews, P L R ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b PFIZER INC   (United States)

^c RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

Behaviour; c fos; Emesis; Ferret; Loperamide; NK1 receptor antagonist

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; LOPERAMIDE; NEUROKININ 1 RECEPTOR; 3-(2-METHOXYBENZYLAMINO)-2-PHENYLPIPERIDINE; ANTIDIARRHEAL AGENT; PIPERIDINE DERIVATIVE; PROTEIN C FOS;

ANIMAL EXPERIMENT; ANTIEMETIC ACTIVITY; ARTICLE; DRUG ANTAGONISM; DRUG EFFECT; DRUG RECEPTOR BINDING; FERRET; NONHUMAN; PRIORITY JOURNAL; PROTEIN INDUCTION; SOLITARY TRACT NUCLEUS; VOMITING; ANIMAL; BIOSYNTHESIS; BRAIN STEM; CHEMICALLY INDUCED DISORDER; FEMALE; IMMUNOLOGY; MALE; METABOLISM; PSYCHOMOTOR PERFORMANCE;

ANIMALS; ANTIDIARRHEALS; BRAIN STEM; FEMALE; FERRETS; LOPERAMIDE; MALE; PIPERIDINES; PROTO-ONCOGENE PROTEINS C-FOS; PSYCHOMOTOR PERFORMANCE; RECEPTORS, NEUROKININ-1; VOMITING;

EID: 0033622021     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(99)00113-6     Document Type: Article

References (28)

1. Andrews P.L.R., Davis C.J., Bingham S., Davidson H.I.M., Hawthorn J., Maskell L. The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity. Canadian Journal of Physiology and Pharmacology. 68:1990;325-345.
2. 3 receptor antagonist BRL 43694. British Journal of Cancer. 58:1988;644-650.
3. 3 receptors. Neuropharmacology. 31:1992;735-742.
4. Bountra C., Bunce K., Dale T., Gardner C., Jordan C., Twissell D., Ward P. Antiemetic profile of a non-peptide neurokinin-1 receptor antagonist, CP-99,994, in ferrets. European Journal of Pharmacology. 249:1993;R3-R4.
5. Cooper J.R., Mattsson J.L. Control of radiation-induced emesis with promethazine, cimetidine, thiethylperazine, or naloxone. American Journal of Vetinary Research. 40:1979;1057-1061.
6. Davis C.J., Harding R.K., Leslie R.A., Andrews P.L.R. The organisation of vomiting as a protective reflex. Davis C.J., Lake-Bakaar G.C., Grahame-Smith D.G. Nausea and Vomiting: Mechanisms and Treatment. 1986;63-75 Springer-Verlag, Berlin.
7. Fox R.A. Current status; animal models of nausea. Bianchi A.L., Grélot L., Miller A.D., King G.L. Mechanisms and Control of Emesis. vol. 223:1992;341-350 Colloque INSERM/John Libbey Eurotext Ltd.
8. 1 receptor antagonist. British Journal of Pharmacology. 124:1998;1643-1650.
9. King G.L. Characterization of radiation-induced emesis in the ferret. Radiation Research. 114:1988;599-612.
10. King G.L. Animal models in the study of nausea and vomiting. Canadian Journal of Physiology and Pharmacology. 68:1990;260-268.
11. Lang I.M., Sarna S.K., Condon R.C. Gastrointestinal motor correlates of vomiting in the dog: quantification and characterization as an independent phenomenon. Gastroenterology. 90:1986;40-47.
12. Lang I.M., Sarna S.K., Dodds W.J. Pharyngeal, esophageal, and proximal gastric responses associated with vomiting. American Journal of Physiology. 265:1993;G963-G972.
13. Leslie R.A., Reynolds D.J.M. Functional anatomy of the emetic circuitry in the brainstem. Bianchi A.L., Grélot L., Miller A.D., King G.L. Mechanisms and Control of Emesis. vol. 223:1992;19-27 Colloque INSERM/John Libbey Eurotext Ltd.
14. Mattsson J.L., Yochmowitz M.G. Radiation-induced emesis in monkeys. Radiation Research. 82:1980;191-199.
15. Morest D.K. A study of the structure of the area postrema with Golgi methods. American Journal of Anatomy. 107:1960;291-303.
16. Reynolds, D.J.M., 1993. Functional anatomy and neuropharmacology of emesis. D.Phil. Thesis, University of Oxford.
17. 3 receptor antagonists act as anti-emetics? Reynolds D.J.M., Andrews P.L.R., Davis C.J. Serotonin and the Scientific Basis of Anti-emetic Therapy. 1995;111-126 Oxford Clinical Communications, Oxford, UK.
18. 3 receptor antagonist granisetron (BRL 43694). Brain Research. 565:1991;231-236.
19. Reynolds D.J.M., Leslie R.A., Taylor H.M. C-fos induction in the ferret area postrema elicited by emetic drugs. Canadian Journal of Physiology and Pharmacology. 72:1994;371.
20. Sheldrick R.L.G., Smith J.R., Gale J.D. The effect of ondansetron and CP-99,994 on emesis induced by rolipram in conscious ferrets. British Journal of Pharmacology. 116:1995;399P.
21. Stoessl A.J., Dourish C.T., Iversen S.D. Pharmacological characterization of the behavioural syndrome induced by the NK-3 tachykinin agonist senktide in rodents: evidence for mediation by endogenous 5-HT. Brain Research. 517:1990;111-116.
22. Tattersall F.D., Rycroft W., Hargreaves R.J., Hill R.G. The tachykinin NK-1 receptor antagonist CP 99,994 attenuates cisplatin induced emesis in the ferret. European Journal of Pharmacology. 250:1993;R5-R6.
23. 1 receptor antagonist CP 99,994. Neuropharmacology. 33:1994;259-260.
24. 1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. Neuropharmacology. 35:1996;1121-1129.
25. Taylor H.M., Reynolds D.J.M. Opioid-induced emesis in the ferret. British Journal of Pharmacology. 112:1994;337P.
26. Thompson P.I., Bingham S., Andrews P.L.R., Patel N., Joel S.P., Slevin M.L. Morphine 6-glucuronide - a metabolite of morphine with greater emetic potency than morphine in the ferret. British Journal of Pharmacology. 106:1992;3-8.
27. Watson J.W., Gonsalves S.F., Fossa A.A., McLean S., Seeger T., Obach S., Andrews P.L.R. Anti-emetic effects of CP 99,994 in the ferret and the dog: role of the NK-1 receptor. British Journal of Pharmacology. 115:1995;84-94.
28. Watson J.W., Nagahisa A., Lucot J.B., Andrews P.L.R. The tachykinins and emesis: towards complete control? Reynolds D.J.M., Andrews P.L.R., Davis C.J. Seroton in and the Scientific Basis of Anti-emetic Therapy. 1995;233-238 Oxford Clinical Communications, Oxford, UK.