Tachykinin NK1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets

Neuropharmacology

Volumn 35, Issue 8, 1996, Pages 1121-1129

  Tattersall, F D ^a   Rycroft, W ^a   Francis, B ^b   Pearce, D ^a   Merchant, K ^a   MacLeod, A M ^a   Ladduwahetty, T ^a   Keown, L ^a   Swain, C ^a   Baker, R ^a   Cascieri, M ^b   Ber, E ^b   Metzger, J ^b   MacIntyre, D E ^b   Hill, R G ^a   Hargreaves, R J ^a  

^a NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Brain penetration; CP 99,994; Emesis; L 741,671; L 743,310; NK1 receptor antagonists

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; 5 [[3 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 2 PHENYL 1 PIPERIDINYL]METHYL] 1,2 DIHYDRO 3H 1,2,4 TRIAZOL 3 ONE; CISPLATIN; L 743310; RESINIFERATOXIN; TACHYKININ RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; 3-(2-METHOXYBENZYLAMINO)-2-PHENYLPIPERIDINE; ANTIEMETIC AGENT; ANTINEOPLASTIC AGENT; DITERPENE; INDOLE DERIVATIVE; LIGAND; NEUROKININ 1 RECEPTOR; NEUROTOXIN; PIPERIDINE DERIVATIVE; PLASMA PROTEIN; TRIAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHINESE HAMSTER; CONTROLLED STUDY; ENANTIOMER; FERRET; GUINEA PIG; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; OVARY CELL; PRIORITY JOURNAL; RECEPTOR BINDING; VOMITING; ANIMAL; BRAIN LEVEL; CELL LINE; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHYSIOLOGY; RADIOASSAY;

ANIMALS; ANTIEMETICS; ANTINEOPLASTIC AGENTS; BLOOD PROTEINS; BRAIN CHEMISTRY; CELL LINE; CISPLATIN; DITERPENES; FERRETS; GUINEA PIGS; INDOLES; LIGANDS; MALE; NEUROTOXINS; PIPERIDINES; RADIOLIGAND ASSAY; RECEPTORS, NEUROKININ-1; TRIAZOLES; VOMITING;

EID: 0030299823     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00020-2     Document Type: Article

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