Resistance to β-Lactams and Glycopeptides in Staphylococci and Streptococci (a review)

Acta Microbiologica et Immunologica Hungarica

Volumn 48, Issue 3-4, 2001, Pages 359-391

  Rozgonyi, Ferenc ^a   Ostorházi, Eszter ^a   Maródi, Csaba L ^a   Ghidán, Ágoston ^a  

^a SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

Enterococci; Glycopeptide resistance; Staphylococci; Streptococci; lactam resistance

Indexed keywords

ANTIINFECTIVE AGENT; BETA LACTAM; BETA LACTAMASE; GLYCOPEPTIDE;

ANTIBIOTIC RESISTANCE; DRUG EFFECT; ENTEROCOCCUS; ENZYMOLOGY; GENETICS; PHENOTYPE; PHYSIOLOGY; REVIEW; STAPHYLOCOCCUS; STREPTOCOCCUS;

ANTI-BACTERIAL AGENTS; BETA-LACTAMASES; BETA-LACTAMS; DRUG RESISTANCE, BACTERIAL; ENTEROCOCCUS; GLYCOPEPTIDES; PHENOTYPE; STAPHYLOCOCCUS; STREPTOCOCCUS;

EID: 0035748425     PISSN: 12178950     EISSN: None     Source Type: Journal    
DOI: 10.1556/AMicr.48.2001.3-4.8     Document Type: Review

References (136)

1. Cormican, M.G., Jones, R.N.: Emerging resistance to antimicrobial agents in gram-positive bacteria. Enterococci, staphylococci and non-pneumococcal streptococci. Drugs; 51 Suppl 1,6 (1996).
2. Cars, O. Colonization and infection with resistant gram-positive cocci. Epidemiology and risk factors. Drugs; 54 Suppl 6,4 (1997).
3. Baquero, F. Gram-positive resistance challenge for the development of new antibiotics. J Antimicrob Chemother.; 39 Suppl A,1 (1997).
4. Barie, P.S. Antibiotic-resistant gram-positive cocci implications for surgical practice. World J Surg 22,118 (1998).
5. Weber, D.J., Raasch, R., Rutala, W.A. Nosocomial infections in the ICU the growing importance of antibiotic-resistant pathogens. Chest; 115 (3 Suppl),34S (1999).
6. File, T.M. Jr. Overview of resistance in the 1990s. Chest; 115 (3 Suppl),3S (1999).
7. Richards, M.J., Edwards, J.R., Culver, D.H., Gaynes, R.P. and the National Nosocomial Infections Surveillance System Nosocomial infections in medical intensive care units in the United States. Crit Care Med; 27,887 (1999).
8. Abb, J. Five-year surveillance of antimicrobial resistance of Streptococcus pneumoniae in large southwestern German community hospital. Clin Microbiol Infect; 287,387 (1999)
9. Wilson, A.P.R. Emerging antimicrobial resistance in the surgical compromised host. J Chemother; 11(6),518 (1999)
10. Edgeworth, J.D., Treacher, D.F., Eykyn, S.J. A 25-year study of nosocomial bacteriaemia in an adult intensive care unit. Crit Care Med; 27,1421 (1999).
11. st Ed. Apleton and Lange pp.145 (1995).
12. Blumberg, P.M., Strominger, J.L. Interaction of penicillin with the bacterial cell Penicillin-binding proteins and penicillin-sensitive enzymes. Bacteriol. Rev; 38,291 (1974).
13. Rozgonyi, F., Kiss, J., Biacs, P., Lévai, G., Váczi, L. Mode of action of methicillin on Staphylococcus aureus. Zbl. Bakt. I. Abt; Suppl. 5,1063 (1976).
14. Rozgonyi, F., Biacs, P., Szitha, K., Kiss, J. Effect of methicillin on the fatty acid composition of phospholipids in methicillin sensitive Staphylococcus aureus. Acta Microbiol Acad Sci hung; 28,97 (1981).
15. Grayson, L., Eliopoulos, G.M., Wennerstern, C. Increasing resistance to β-lactam antibiotics among clinical isolates of Enterococcus faecium a 22-year review at one institution. Antimicrob Ag Chemother; 35,2180 (1991).
16. Rozgonyi, F., Hahn, H., Labischinski, H., Giesbrecht, P. A novel labeling procedure of anteiso-fatty acid-containing lipids in staphylococci for investigating the effect of penicillin on lipid release. FEMS Microbiol Lett; 77,11 (1990).
17. Samuni, A. A direct spectrophotometric determination of Michaelis constants for the β-lactamase reaction. Anal Biochem; 63,17 (1975).
18. Bush, K., Jacoby, G.A., Medeiros, A.A. A functional classification scheme of β-lactamases and its correlation with molecular structure. Antimicrob Ag Chemother; 39,1211 (1995).
19. Dyke, K., Gregory, P. Resistance to β-lactam antibiotics. Resistance mediated by β-lactamase. In Crossley, K. B., Archer, G. L. (eds) The staphylococci in human disease. Churchill Livingstone, New York, pp. 139 (1997).
20. Kiss, L., Toth-Martinez, B.L., Gal, D., Hernadi, F.J., Rozgonyi, F. Investigation of inducible exopenicillinases from eight Staphylococcus aureus strains. Internatl J Clin Chemoter; 4,118 (1999).
21. Jeljaszewicz, J., Mlynarczyk, G., Mlynarczyk, A. Present and future problems of antibiotic resistance in gram-positive cocci. Infection; 26,5 (1998).
22. Kiss, L., Toth-Martinez, B.L., Gal, Z., Hernadi, F.J., Rozgonyi, F. Investigation of inducible exopenicillinases from eight Staphylococcus aureus strains. Internatl J Clin Chemoter; 4,118 (1991).
23. Livermore, D.M. β-lactamases in laboratory and clinical resistance. Clin Microbial Rev; 8,557 (1995).
24. Bruns, O., Bruns, W., Pulverer, G. Regulation of β-lactamase synthesis as a novel site of action for suppression of methicillin resistance in Staphylococcus aureus. Zbl Bakt; 285,413 (1997).
25. Low, D.E. Clinical microbiology Issues in identification and susceptibility testing. In Crossley, K.B., Archer, L.G. (eds) The staphylococci in human disease. Churchill Livingstone, New York pp. 233-252 (1997).
26. Mlynarczyk, A., Mlynarczyk, G., Jeljaszewitz, J. Genome in Staphylococcus aureus a review. Zbl Bakt; 287,277 (1999).
27. Tomasz, A. Auxiliary genes assisting in the expression of methicillin resistance in Staphylococcus aureus. In Novick, R. P., Skurray, R. A. (eds) Molecular biology of the staphylococci. VHC Publishers, Inc., New York pp. 565-583 (1990).
28. Rozgonyi, F. Genotypic stability of methicillin resistance in Staphylococcus aureus at supraoptimal temperature. Antimicrob Ag Chemother; 10,377 (1976).
29. Rozgonyi, F., Rédai, I. The effect of methicillin in combination with trypsin and lysozmyme on the growth of methicillin sensitive and resistant Staphylococcus aureus strains. Acta Microbiol Acad Sci hung; 19,133 (1972).
30. rd Internatl Symp Antibiotic Resistance, Smolenice, 1976, AVICENUM, Prague, and Springer-Verlag, Berlin-Hiedelberg-New York, pp. 353-360 (1977).
31. Rozgonyi, F., Laczkó, J., Váczi, L. Phenotypic expression of resistance to penicillinase-stable β-lactams in Staphylococcus aureus growth rate, cross wall morphogenesis, and cell division cycle. FEMS Microbiol Lett; 14,237 (1982).
32. Rozgonyi, F., Kovács, L., Váczi. L. Genotypic stability of methicillin resistance in Staphylococcus aureus after persistance in mice. Transf Antibiot Resist Avicenum; pp. 269-273 (1984).
33. Bruns, W., Keppeler, H. Mechanism of intrinsic penicillin-resistance in Slaphylococcus aureus. Binding of penicillin G to the cytoplasmic membrane of resistant staphylococci Arzneim Forsch; 30,1469 (1980).
34. Weller, T.M. The distribution of mecA mecR1 and mecI and sequence analysis of mecI and the mec promoter region in staphylococci expression resistance to methicillin. J Antimicrob Chemoter; 43,15 (1999).
35. Dominiquez, M.A., Linares, J., Martin, R. Molecular mechanism of methicillin resistance in Staphylococcus aureus. Microbiologia; 13,301 (1997).
36. Ehlert, K. Methicillin-resistance in Staphylococcus aureus - molecular basis, novel targets and antibiotic therapy. Curr Pharm Des; 5,44 (1999).
37. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial disk susceptibility tests sixth edition; Approved standard M7-A6 National Committee for Clinical Laboratory standards, Villanova, PA (1997).
38. National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing. Fifth information supplement. NCCLS document M100-S6. National Committee for Clinical Laboratory standards, Villanova, PA (1993).
39. Domanski, T.L., Bayles, K.W. Analysis of Staphylococcus aureus genes encoding penicillin-binding protein 4 and an ABC-type transporter. Gene; 167,111 (1995).
40. Wu, S., DeLencastre, H., Tomasz, A. Sigma-B, a putative operon encoding alternate sigma factor of Staphylococcus aureus RNA polymerase molecular cloning and DNA sequencing. J Bacteriol; 178,6036 (1996).
41. Gerberding, J.L., Muck, C., Lin, H.H., Chambers, H.F. Comparison of conventional susceptibility tests with direct detection of PBP2a in borderline oxacillin-resistant strains of Staphylococcus aureus. Antimicrob Ag Chemother; 35,2574 (1991).
42. Tomasz, A., Drugeon, H.B., deLancestre, H.M., Jabes, D., McDougal, L., Bille, J. New mechanism for methicillin resistance in Staphylococcus aureus clinical isolates that lack the PBP2a gene and contain normal PBPs with modified penicillin-binding capacity. Antimicrob Ag Chemother; 33,1874 (1989).
43. Hackbarth, C.J., Kocagöz, T., Kocagöz, S., Chambers, H.F. Point mutation in Staphylococcus aureus PBP2a gene affect penicillin-binding kinetics and are associated with resistance. Antimicrob Ag Chemother; 39,103 (1995).
44. Henze, U.U., Berger-Bachi, B. Penicillin binding protein-4 overproduction increases β-lactam resistance in Staphylococcus aureus. Antimicrob Ag Chemother; 40,2121 (1996).
45. McDougal, L.K., Thornsberry, C. The role of β-lactamase in staphylococcal resistance to penicillinase-resistant penicillin and cephalosporin. J Clin Microbiol; 23,832 (1986).
46. Rozgonyi, F., Rédai, I. The effect of methicillin in combination with trypsin and lysozyme on the growth of methicillin sensitive and resistant Staphylococcus aureus strains. Acta Microbiol Acad Sci hung; 19,133 (1972).
47. Montanari, M.P., Massida, O., Mingoia, M., Varaldo, P.E. Borderline susceptibility to methicillin in Staphylococcus aureus new mechanism of resistance? Microb Drug Resist; 2,257 (1996).
48. Garret, D.O., Jochimsen, E., Murfitt, K. The impending apocalypse, the emergence of vancomycin resistance in Staphylococcus spp. Infect Control Hosp Epidemiol; 18, Suppl,P32. Abstract (1997).
49. Schwalbe, R.S., Stapleton, J.T., Gilligan, P.H. Emergence of vancomycin resistance in coagulase-negative staphylococci. N Eng J Med; 316, 927 (1987).
50. Veach, L.A., Pfaller, M.A., Barrett, M., Koontz, F.P., Wenzel, R.P. Vancomycin resistance in Staphylococcus haemolyticus causing colonization and bloodstream infection. J Clin Microbiol; 28,2064 (1990).
51. Sanyal, D., Johnson, A.P., George, R.C., Cookson, B.D., Williams, A.J. Peritonitis due to vancomycin-resistant Staphylococcus epidermidis. Lancet; 337(2068),54 (1991).
52. Aubert, G., Passot, S., Lucht, F., Dorche, G. Selection of vancomycin- and teicoplanin-resistant Staphylococcus haemolyticus during teicoplanin treatment of S. epidermidis infection. J Antimicrob Chemother; 25,491 (1990).
53. Knausz, M., Ghidán, A., Rozgonyi, F. Nosocomial catheter colonization by teicoplanin-resistant coagulase-negative staphylococci in immunocompromised patients. Clin Microb Infect; 7 Suppl 1,81 (2001).
54. Hiramatsu, K., Hanaki, H., Ino, T., Yabuta, K., Oguri, T., Tenover, F.C. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility. J Antimicrob Chemother; 40,135 (1997).
55. Centers for Disease Control and Prevention Update Staphylococcus aureus with reduced susceptibility to vancomycin - United States, 1997. JAMA; 278(14), 1145-6 (1997) (From the Morbidity and Mortality Weekly Report. 1997; 46, 813
56. Centers for Disease Control and Prevention Update Staphylococcus aureus with reduced susceptibility to vancomycin - United States, 1997. JAMA; 278(14), 1145-6 (1997) (From the Morbidity and Mortality Weekly Report. 1997; 46, 813
57. Lessing, M.P.A., Raftery, M.J. Vancomycin-resistant Staphylococcus aureus [Correspondence]. The Lancet; 351(9102),601 (1998).
58. Predari, S.C., Ligozzi, M., Fontana, R. Genotypic identification of methicillin-resistant coagulase-negative staphylococci by polymerase chain reaction. Antimicrob Ag Chemother; 35,2568 (1991).
59. Sieradzki, K., Roberts, R.B., Haber, S.W., Tomasz, A. Brief report The development of vancomycin resistance in a patient with methicillin-resistant Staphylococcus aureus infection. N Eng J Med; 340,517 (1999).
60. Waldvogel, F.A. New resistance in Staphylococcus aureus [Editorials]. N Eng J Med; 340,556 (1999).
61. Dutka-Malen, S., Evers, S., Courvalin, P. Detection of glycopeptide resistance genotypes and identification to the species level of clinically relevant enterococci by PCR. J Clin Microbiol; 33,24 (1995).
62. Noble, W.C., Virani, Z., Cree, R.G. Co-transfer of vancomycin and other resistance genes from Enterococcus faecalis NCTC 12201 to Staphylococcus aureus. FEMS Microbiol Lett; 93,1958 (1992).
63. Tenover, F.C., Lancaster, M.V., Hill, B.C. Characterization of staphylococci with reduced susceptibilities to vancomycin and other glycopeptides. J Clin Microbiol; 36,1020 (1998).
64. Smith, T.L., Pearson, M.L., Wilcox, K.R. Emergence of vancomycin resistance in Staphylococcus aureus. N Engl J Med; 340,493 (1999).
65. Siedradzki, K., Tomasz, A. Inhibition of cell wall turnover and autolysis by vancomycin in a highly vancomycin resistant mutant of Staphylococcus aureus. J Bacteriol; 179,2557 (1997).
66. Daum, R.S., Gupta, S., Sabbagh, R. Characterization of Staphylococcus aureus isolates with decreased susceptibility to vancomycin and teicoplanin isolation and purification of a constitutively produced protein associated with decreased susceptibility. J Infect Dis; 166,1066 (1992).
67. Shlaes, D.M., Shlaes, J.H., Vincent, S. Teicoplanin resistant Staphylococcus aureus expresses a novel membrane protein and increases expression of penicillin-binding protein-2 complex. Antimicrob Ag Chemother; 37,2432 (1997).
68. Moreira, B.S., deJonge, B.L., Daum, R.S. Increased production of penicillin-binding protein 2, increased detection of other penicillin-binding proteins, and decreased coagulase activity associated with glycopeptide resistance in Staphylococcus aureus. Antimicrob Ag Chemother; 41,1788 (1998).
69. th ed. Washington, D.C. American Society for Microbiology, pp.282-298 (1995).
70. Edmond, M.B., Wenzel, R.P., Pasculle, A.W. Vancomycin-resistant Staphylococcus aureus perspectives on measures needed for control. Ann Intern Med; 124, 329 (1996).
71. Murray, B.E., Mederski-Samaroj, B. Transferable beta-lactamase. A new mechanism for in vitro penicillin resistance in Streptococcus faecalis. J Clin Inv; 72,1168 (1983).
72. Murray, B.E. Beta-lactamase-producing enterococci. Antimicrob Ag Chemother; 36,2355 (1992).
73. Rice, L.B., Marshall, S.H. Evidence of incorporation of the chromosomal beta-lactamase gene of Enterococcus faecalis CH19 into a transposon derived from staphylococci. Antimicrob Ag Chemother; 36,1843 (1992).
74. Coundron, P.E., Markowitz, S.M., Wong, E.S. Isolation of beta-lactamase-producing, aminoglycoside-resistant strain of Enterococcus faecium. Antimicrob Ag Chemother; 32,1125 (1992).
75. Patterson, J.E., Masecar, B.L., Zervos, M.J. Characterization and comparison of two penicillinase-producing strains of Streptococcus (Enterococcus) faecalis. Antimicrob Ag Chemother; 32,122 (1988).
76. Bush, L.M., Calmon, J., Cherney, C.L., Wendeler, M., Pitsakis, P., Pouppard, J. High-level penicillin resistance among isolates of enterococci. Ann Intern Med; 110,515 (1989).
77. Grayson, L., Eliopoulos, G.M., Wennerstern, C. Increasing resistance to β-lactam antibiotics among clinical isolates of Enterococcus faecium a 22-year review at one institution. Antimicrob Ag Chemother; 35,2180 (1991).
78. Murray, B.E. The life and times of the Enterococcus. Clin Microbiol Rev; 3,46 (1990).
79. Torres, C., Tenorio, C., Lantero, M., Gastanares, M.J., Baquero, F. High-level penicillin resistance and penicillin-gentamicin synergy in Enterococcus faecium. Antimicrob Ag Chemother; 37,2427 (1993).
80. Bryce, E.A., Zemcov, S.J., Clarke, A.M. Species identification and antibiotic resistance patterns of the enterococci. Eur J Clin Microbiol Inf Dis; 10,745 (1991).
81. Marshall, S.A., Sutton, L.D., Jones, R.N. Evaluation of S1 chromogenic cephalosporin beta-lactamase disk assay tested against gram-positive anaerobes, coagulase-negative staphylococci, Prevotella spp. Enterococcus spp. Diagn Microbiol Infect Dis; 22,353 (1995)
82. Handwerger, S., Periman, D.C., Altarac, D., McAuliffe, V. Concomittant high-level vancomycin and penicillin resistance in clinical isolates of enterococci. Clin Infect Dis; 14,655 (1992).
83. Snell, J.J.S., Brown, D.F.J., Perry, S.F., George, R.C. Antimicrobial susceptibility testing of enterococci results of a survey conducted by the United Kingdom National External Quality Assessment Scheme for Microbiology. J Antimicrob Chemother; 32, (1993).
84. Sanchez, M.L., Barrett, M.S., Jones, R.N. The E-test applied to susceptibility tests of gonococci, multiple-resistant enterococci, and Enterobacteriaceae producing potent beta-lactamases. Diagn Microbiol Infect Dis; 15,459 (1992).
85. Schulz, J.E., Sahm, D.F. Reliability of E-test for detection of ampicillin, vancomycin, and high-level aminoglycoside resistance in Enterococcus spp. J Clin Microbiol; 31,3336 (1993).
86. Iwen, P.C., Kelly, D.M., Linder, J., Hinrichs, S.H. Revised approach for identification and detection of ampicillin and vancomycin resistance in Enterococcus species by using MicroScan panels. J Clin Microbiol; 34,1779 (1996).
87. Wakanakunakorn, W. Enterococci from blood cultures during 1980-1989 susceptibilities to ampicillin, penicillin and vancomycin. J Antimicrob Chemother; 26,602 (1990).
88. Hodel-Christian, S.L., Murray, B.E. Characterization of the gentamicin-resistance transposon Tn5218 from Enterococcus faecalis and comparison to staphylococcal transposons Tn4001 and Tn4301. Antimicrob Ag Chemother; 35,21 (1991).
89. Leclercq, R., Derlot, E., Duval, J. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcusfaecium. N Engl J Med; 319,157 (1988).
90. Shlaes, D.M., AL-Obeid, S., Shlaes, J.H. Inducible, transferable resistance to vancomycin in Enterococcus faecium D 399. J Antimicrob Chemother; 23,503 (1989).
91. Chow, J.W., Kuritza, A., Schlaes, D.M. Clonal spread of vancomycin-resistant Enterococcus faecium between patients in three hospitals in two states. J Clin Microbiol; 31,1609 (1993).
92. Frieden, T.R., Munsitt, S., Low, D.E. Emergence of vancomycin-resistant enterococci in New York City. Lancet; 342,76 (1993).
93. Klare, I., Witte, W., Reinhardt, A. Ausbrüche von Infektionen mit vanA-positiven, high-level glykopeptidresistenten Enterococcus faecium in Deutschland. Poster-Abstract Nr. 154, 48. Bonn, DGHM-Tagung (1996).
94. Livornese, L.L. Jr, Dias, S., Samuel, C. Hospital-acquired infection with vancomycin-resistant Enterococcus faecium transmitted by electronic thermometers. Ann Intern Med; 117,112 (1992).
95. Bingen, E.H., Denamur, E., Lambert-Zechovsky, N. Evidence for the genetic unrelatedness of nosocomial vancomycin-resistant Enterococcus faecium strains in a pediatric hospital. J Clin Microbiol; 29,1888 (1991).
96. Centers for Disease Control. Recommendations for preventing the spread of vancomycin resistance. Morbid Mortal Wkl Rep; 44(No. RR12),1 (1995).
97. Devrise, L.A., Pot, B., Collins, M.D. Phenotypic identification of the genus Enterococcus and differentiation of phylogenetically distinct enterococcal species and species groups. J Appl Bacteriol; 75,399 (1993).
98. Woodford, N., Johnson, A., Morrison, D. Current perspectives on glycopeptide resistance. Clin Microbiol Rev; 8,585 (1995).
99. Reinert, R.R., Conrads, G., Schlaeger, J.J., Werner, G., Witte, W., Lütticken, R., Klare, I. Survey of antibiotic resistance among eterococci in North Rhine-Westphalia, Germany. J Clin Microbiol; 37,1638 (1999).
100. Arthur, M., Courvalin, P. Genetics and mechanism of glycopeptide resistance in enterococci. Antimicrob Ag Chemother; 37,1563 (1993).
101. Perichon, B., Reynolds, P., Courvalin, P. VanD-type glycopeptide-resistant Enterococcus faecium BM4339. Antimicrob Ag Chemother; 41,2016 (1997).
102. Fines, M.B., Perichon, P., Reynolds, D.F., Sahm, P., Courvalin VanE, a new type of acquired glycopeptide resistance in Enterococcus faecalis BM4405. Antimicrob Ag Chemother; 43,2161 (1999).
103. Leclercq, R., Dutka-Malen, S., Duval, J., Courvalin, P. Vancomycin resistant gene vanC is specific to Enterococcus gallinarum. Antimicrob Ag Chemother; 36,2005 (1992).
104. Navarro, F., Courvalin, P. Analysis of genes encoding D-alanineD-alanine ligase-related enzymes in Enterococcus casseliflavus and Enterococcus flavescens. Antimicrob Ag Chemother; 38,1788 (1993).
105. Dutka-Malen, S., Leclercq, R., Coutant, V. Phenotypic and genotypic heterogeneity of glycopeptide resistance determinants in Gram-positive bacteria Antimicrob Ag Chemother; 34,1875 (1990).
106. Arthur, M., Reynolds, P.E., Courvalin, P. Glycopeptide resistance in enterococci. Trends Microbiol; 4,401 (1996).
107. Arthur, M., Molinas, C., Courvalin, P. The VanS-VanR two component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol; 174,2582 (1992).
108. Arthur, M., Molinas, C., Depardieu, F., Courvalin, P. Characterization of Tn1546, a Tn3-related transposon conferring glycopeptide resistance by synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147. J Bacteriol; 175,117 (1993).
109. B two component regulatory system in E. faecalis V583. J Bacteriol; 178,1302 (1996).
110. Bugg, T.D.H., Dutka-Malen, S., Arthur, M. Identification of vancomycin resistance protein VanA as a D-alanine-D-alanine ligase of altered substrate specificity. Biochemistry; 30,2017 (1991).
111. Dutka-Malen, S., Molinas, C., Arhur, M. The VanA glycopeptide resistance protein is related to D-alanyl-D-alanine ligase cell wall biosynthesis enzymes. Mol Gen Genet; 224,364 (1990).
112. Quintiliani, R., Jr., Evers, S., Courvalin, P. The vanB gene confers various levels of self-transferable resistance to vancomycin in enterococci. J Infect Dis; 167,1220 (1993).
113. Vincent, S., Knight, R.G., Green, M., Sahm, D.F., Shlaes, D.M. Vancomycin susceptibility and identification of motile enterococci. J Clin Microbiol; 29,2335 (1991).
114. Sahm, D. F., Olsen, L. In vitro detection of enterococcal vancomycin resistance. Antimicrob Ag Chemother; 34,1846 (1990).
115. Tenover, F. C., Tokars, J., Swenson, J., Paul, S., Spitalny, K., Jarvis, W. Ability of clinical laboratories to detect antimicrobial agent-resistant enterococci. J Clin Microbiol; 31,1695 (1993).
116. Tomasz, A. Multiple-antibiotic-resistant pathogenic bacteria a report on the Rockefeller University workshop. N Engl J Med; 330,1247 (1994).
117. Uttley, A.H.C., George, R.C., Naidoo, J. High-level vancomycin-resistant enterococci causing hospital infection. Epidemiol Infect; 103,173 (1989).
118. Courvalin, P. Genotypic approach to the study of bacterial resistance to antibiotics. Antimicrob Ag Chemother; 35,1019 (1991).
119. Eyers, M., Chapelle, G., Van Camp, H., Goossens, D., De Wachter, R. Discrimination among thermophilic Campylobacter species by polimerase chain reaction amplification of 23S gene fragments. J Clin Microbiol; 27,731 (1993).
120. Frankel, G., Giron, J.A., Valmossoi, J., Schoolnik, G.K. Multi-gene amplification, simultaneous detection of three virulence genes in diarrhoeal stool. Mol Microbiol; 31729 (1989).
121. Oyofo, B., Thornton, S.A., Burr, D.H., Trust, T.J., Pavlovskis, O.R., Guerry, P. Specific detection of Campylobacter jejuni and Campylobacter coli by using polymerase chain reaction. J Clin Microbiol; 30,2613 (1992).
122. Ghidán, Á., Jeney, Cs., Maródi, Cs.L., Csiszár, K., Rozgonyi, F. PCR detection of the vanA gene in vancomycin-resistant Enterococcus faecalis clinical isolate from Hungary. J Antimicrob Chemother; 46,325 (2000)
123. Klare, I., Heier, H., Claus, H. Environmental strains of Enterococcus faecium with inducible high-level resistance to glycopeptides. FEMS Microbiol Lett; 106,23-30 (1993) and Addendum FEMS Microbiol Lett; 107,349 (1993).
124. Klare, I., Heier, H., Claus, H. Environmental strains of Enterococcus faecium with inducible high-level resistance to glycopeptides. FEMS Microbiol Lett; 106,23-30 (1993) and Addendum FEMS Microbiol Lett; 107,349 (1993).
125. Klare, I., Heier, H., Claus, H. vanA-mediated high-level glycopeptide resistance in Enterococcus faecium from animal husbandry. FEMS Microbiol Lett; 125,165 (1995).
126. Kunstmann, M.P., Mitscher, L.A., Porter, J.N. LL-AV290, a new antibiotic. I. Fermentation, isolation, and characterization. Antimicrob Ag Chemother; 37,242 (1996).
127. Murray, B.E., Mederski-Samoraj, B., Foster, S.K. In-vitro studies of plasmid-mediated penicillinase from Streptococcus faecalis suggest a staphylococcal origin. J Clin Invest; 77,289 (1986).
128. Murray, B.E., Mederski-Samoraj, B. Transferable β-lactamase. A new mechanism for in vitro penicillin resistance in Streptococcus faecalis. J Clin Invest; 72,289 (1983).
129. French, G., Abdulla, Y., Heathcock, R. Vancomycin resistance in south London. Lancet; 339,818 (1992).
130. Power, E.G.M., Abdulla, Y.H., Talsania, H.G. vanA genes in vancomycin-resistant clinical isolates of Oerskovia turbata and Arcanobacterium (Corynebacterium) haemolyticum. J Antimicrob Chemother; 36,595 (1995).
131. Rozgonyi, F., Knausz, M., Dömötör, I., Gartner, B., Ghidán, Á. Vancomycin-resistant Enterococcus faecalis superinfection during recovery from Neisseria meningitidis cerebrospinal meningitis. Spa J Chemother; 13 Suppl.2,120 (2000).
132. Spratt, B.G. Resistance to antibiotics mediated by target alteration. Science; 264,388 (1994).
133. Bradley, J.S., Connor, J.D. Ceftriaxone failure in meningitis caused by Streptococcuspneumoniae with reduced susceptibility to beta-lactam antibiotics. Pediatr Infect Dis J; 10,871 (1991).
134. Hakenbeck, R., Tornette, S., Adkinson, N.F. Interaction of non-lytic beta-lactams with penicillin-binding proteins in Streptococcus pneumoniae. J Gen Microbiol; 176,333 (1987).
135. Glatz, K., Szabó, D., Szabó, G., Boriszova, D., Rozgonyi, F. Emergence of extremly high penicillin and cefotaxime resistance and high level levofloxacin resistance in clinical isolates of Streptococcus pneumoniae in Hungary. J Antimicrob Chemother submitted (2001).
136. Jalal, H., Organji, S., Reynolds, J., Bennett, D., O'Mason, E., Millar, M.R. Determination of penicillin susceptibility of Streptococcus pneumoniae using the polymerase chain reaction. Mol Pathol; 50,45 (1997).