A 25-year study of nosocomial bacteremia in an adult intensive care unit

Critical Care Medicine

Volumn 27, Issue 8, 1999, Pages 1421-1428

  Edgeworth, Jonathan D ^a   Treacher, David F ^a   Eykyn, Susannah J ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Aminoglycoside; Antibiotic prescribing; Antibiotic susceptibility; Bacteremia; Blood cultures; Bloodstream infection; Fungemia; Intensive care; Intravascular catheter; Mortality; Nosocomial infection

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMOXICILLIN; ANTIBIOTIC AGENT; CEFTAZIDIME; CEPHALOSPORIN; GENTAMICIN;

ANTIBIOTIC SENSITIVITY; BACTEREMIA; BACTERIUM ISOLATION; BLOOD CULTURE; DRUG USE; FUNGEMIA; GRAM NEGATIVE BACTERIUM; HOSPITAL INFECTION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; REVIEW;

ADULT; BACTEREMIA; CATHETERS, INDWELLING; CROSS INFECTION; DISEASE OUTBREAKS; DRUG RESISTANCE, MICROBIAL; DRUG UTILIZATION; EQUIPMENT CONTAMINATION; HOSPITALS, UNIVERSITY; HUMANS; INFECTION CONTROL; INFUSIONS, INTRAVENOUS; INTENSIVE CARE UNITS; LONDON; MICROBIAL SENSITIVITY TESTS; PATIENT ADMISSION; PROSPECTIVE STUDIES; RISK FACTORS;

EID: 0032839548     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199908000-00002     Document Type: Review

References (36)

1. 1. Donowitz LG, Wenzel RP, Hoyt JW: High risk of hospital-acquired infection in the ICU patient. Crit Care Med 1982; 10:355-357
2. 2. Wenzel RP, Thompson RL, Landry SM: Hospital acquired infections in intensive care unit patients: An overview with emphasis on epidemics. Infect Control 1983; 4:371-375
3. 3. Schaberg DR, Culver DH, Gaynes RP: Major trends in the microbial etiology of nosocomial infection. Am J Med 1991; 91:725-755
4. 4. Pittet D: Nosocomial bloodstream infection. In: Prevention and Control of Nosocomial Infections. Wenzel RP (Ed). Baltimore, Williams & Wilkins, 1993, pp 512-555
5. 5. Jarvis WR, Edwards JR, Culver DH, et al: Nosocomial infection rates in adult and pediatric intensive care units in the United States. Am J Med 1991; 91(Suppl 3B):185S-191S
6. 6. Banerjee SN, Emori TG, Culver DH, et al: Secular trends in nosocomial primary bloodstream infections in the United States, 1980-1989: National Nosocomial Infections Surveillance System. Am J Med 1991; 91(Suppl 3B):86S-89S
7. 7. Gatell JM, Trilla A, Latorre X, et al: Nosocomial bacteremia in a large Spanish teaching hospital: Analysis of factors influencing prognosis. Rev Infect Dis 1988; 10:203-210
8. 8. Brun-Bruisson C, Doyon F, Carlet J: Bacteremia and severe sepsis in adults: A multicenter prospective survey in ICUs and wards of 24 hospitals. Am J Respir Crit Care Med 1996; 154:617-624
9. 9. Rello J, Ricart M, Mirelis B, et al: Nosocomial bacteremia in a medical-surgical intensive care unit: Epidemiological characteristics and factors influencing mortality in 111 episodes. Intensive Care Med 1994; 20:94-98
10. 10. Pittet D, Tarara D, Wenzel RP: Nosocomial bloodstream infection in critically ill patients: Excess length of stay, extra costs and attributable mortality. JAMA 1994; 271: 1598-1601
11. 11. Valles J, Leon C, Alvarez-Lerma F, et al: Nosocomial bacteremia in critically ill patients: A multicenter study evaluating epidemiology and prognosis. Clin Infect Dis 1997; 24: 387-395
12. 12. Forgacs IC, Eykyn SJ, Bradley RD: Serious infection in the intensive therapy unit: A 15 year study of bacteraemia. Quart J Med 1986; 232:773-779
13. 13. Craven DE, Kunches LM, Lichtenberg DA, et al: Nosocomial infection and fatality in medical and surgical intensive care unit patients. Arch Intern Med 1988; 148:1161-1168
14. 14. Dominguez de Villota E, Algora A, Jubio JJ, et al: Septicemia in a medical intensive care unit: Clinical, biochemical and microbiological data of 109 cases. Intensive Care Med 1983; 9:109-115
15. 15. Pittet D, Thievent B, Wenzel RP, et al: Importance of pre-existing co-morbidities for prognosis of septicemia in critically ill patients. Intensive Care Med 1993; 19:265-272
16. 16. Crowe M, Ispahani P, Humphreys H: Bacteraemia in an adult intensive care unit over 11 years. Abstr. J Infect 1997; 34:172
17. 17. Bates DW, Sands K, Miller E, et al: Predicting bacteremia in patients with sepsis syndrome. J Infect Dis 1997; 176:1538-1551
18. 18. Gransden WR, Eykyn SJ, Phillips I: The computerised documentation of septicaemia. J Antimicrob Chemother 1990; 25(Suppl C): 31-39
19. 19. Phillips I, King A, Gransden WR, et al: The antibiotic sensitivity of bacteria isolated from the blood of patients in St. Thomas' Hospital, 1969-1988. J Antimicrob Chemother 1990; 25(Suppl C):59-80
20. 20. British Society for Antimicrobial Chemotherapy Working Party: A guide to sensitivity testing. London, Academic Press, 1991
21. 21. Maki DG, Weise CE, Safarin HW: A semiquantitative method for identifying intravenous-catheter-related infection. N Engl J Med 1977; 296:1305-1309
22. 22. Maki DG: Infections associated with indwelling medical devices. In: Pathogenesis, Prevention, and Management of Infections Due to Intravascular Devices Used for Infusion Therapy. Bisno AL, Waldvogel FA (Eds). Washington DC, American Society for Microbiology, 1989, pp 161-177
23. 23. Leroy O, Billiau V, Beuscart C, et al: Nosocomial infections associated with long-term radial artery catheterization. Intensive Care Med 1989; 15:241-246
24. 24. Eykyn SJ: Bacteraemia, septicaemia and endocarditis. In: Topley and Wilson's Microbiology and Microbial Infection. Vol 3. Hansler WJ, Sussman M (Eds). London, Arnold, 1998, pp 277-298
25. 25. Widmer AF: IV-related infections. In: Prevention and Control of Nosocomial Infections. Wenzel RP (Ed). Baltimore, Williams & Wilkins, 1993, pp 556-579
26. 26. Aronson MD, Bor DH: Blood cultures. Arch Intern Med 1987; 106:246-253
27. 27. Washington FA, and the International Collaborative Blood Culture Study Group: An international multicenter study of blood culture practices. Eur J Clin Microbiol Infect Dis 1992; 11:1115-1128
28. 28. Pittet D, Wenzel RP: Nosocomial bloodstream infections: Secular trends in rates, mortality and contribution to total hospital deaths. Arch Intern Med 1995; 155: 1177-1184
29. 29. Geerdes HF, Ziegler D, Lode H, et al: Septicemia in 980 patients at a university hospital in Berlin: Prospective study during 4 selected years between 1979 and 1989. Clin Infect Dis 1992; 15:991-1002
30. 30. Brun-Buisson C, Abrouk F, Legrand P, et al: Diagnosis of central venous catheter-related sepsis: Critical level of semiquantitative tip cultures. Arch Intern Med 1987; 147: 873-877
31. 31. Scherertz RJ, Heard SO, Raad II: Diagnosis of triple-lumen catheter infection: Comparison of roll plate, sonication and flushing methodologies. J Clin Microbiol 1997; 35:641-646
32. 32. Prager RL, Silva J: Colonization of central venous catheters. South Med J 1984; 77: 458-461
33. 33. Ricard P, Martin R, Marcoux JA: Protection of indwelling catheters: Incidence of bacterial contamination and catheter related sepsis. Crit Care Med 1985; 13:541-543
34. 34. Richet H, Hubert B, Nitemberg G, et al: Prospective multicenter study of vascular catheter related complications and risk factors for positive central catheter cultures in intensive care unit patients. J Clin Microbiol 1990; 28:2520-2525
35. 35. Darby JM, Linden PL, Pasculle W, et al: Utilization and diagnostic yield of blood cultures in a surgical intensive care unit. Crit Care Med 1997; 25:989-994
36. 36. French GL, Phillips I: Resistance. In: Antibiotic and Chemotherapy: Anti-infective Agents and Their Use in Therapy. O'Grady F, Lambert HP, Finch RG, et al (Eds). London, Churchill Livingstone, 1997, pp 23-43