Antenatal glucocorticoids and the developing brain: Mechanisms of action

Seminars in Neonatology

Volumn 6, Issue 4, 2001, Pages 309-317

  Matthews, Stephen G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Behaviour; Fetal programming; Hippocampus; Neurotransmitters; Prenatal glucocorticoid

Indexed keywords

CORTICOSTEROID RECEPTOR; GLUCOCORTICOID; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BEHAVIOR; BRAIN DEVELOPMENT; BRAIN MATURATION; BRAIN REGION; DRUG EFFECT; DRUG MECHANISM; FETUS; HIPPOCAMPUS; MALE; NEUROENDOCRINE SYSTEM; NONHUMAN; PRENATAL DRUG EXPOSURE; RAT; REVIEW; SEX DIFFERENCE; STEROID THERAPY;

EID: 0035740121     PISSN: 10842756     EISSN: None     Source Type: Journal    
DOI: 10.1053/siny.2001.0066     Document Type: Article

References (61)

1. Glucocorticoid induced teratologies of the nervous system
2. Does prenatal stress impair coping and regulation of hypothalamic-pituitary-adrenal axis
3. Brain corticosteroid receptor balance in health and disease
4. Learning and memory: Basic mechanisms
5. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis
6. The acute effects of corticosteroids on cognition: Integration of animal and human model studies
7. Comparative aspects of the brain growth spurt
8. Regulation of the hypothalamo-pituitary-adrenocortical axis in fetal sheep
9. Dynamic changes in glucocorticoid and mineralocorticoid receptor mRNA in the developing guinea pig brain
10. Developmental and functional biology of the primate fetal adrenal cortex
11. Maturation of the adrenocortical stress response: Neuroendocrine control mechanisms and the stress hyporesponsive period
12. Neural development in metatherian and eutherian mammals: Variation and constraint
13. Corticosteroids and lymphoid cells
14. Corticosteroids and the control of function in the hypothalamo-pituitary-adrenal (HPA) axis
15. An orphan nuclear receptor activated by pregnanes defines a novel steroid signalling pathway
16. Distinct ontogeny of glucocorticoid and mineralocorticoid receptor and 11b-hydroxysteroid dehydrogenase types I and II mRNAs in the fetal rat brain suggest a complex control of glucocorticoid actions
17. Endocrine and paracrine regulation of birth at term, and preterm
18. Regulation of glucocorticoid receptor mRNA and heat shock protein 70 mRNA in the developing sheep brain
19. Glucocorticoid receptors immunoreactivity in tissue of human embryos
20. Glucocorticoids, feto-placental 11b-hydroxysteroid dehydrogenase type 2, and the early life origins of adult disease
21. Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice
22. The physiological function of drug-transporting P-glycoproteins
23. Development of MDR1a expression in the guinea pig brain: Implications for fetal glucocorticoid exposure
24. Repeated antenatal glucocorticoid treatment decreases hypothalamic corticotropin releasing hormone mRNA but not corticosteroid receptor mRNA expression in the fetal guinea pig brain
25. Prenatal corticosterone treatment induces long-term changes in spontaneous and apomorphine-mediated motor activity in male and female rats
26. Prenatal dexamethasone or stress but not ACTH or corticosterone alter sexual behavior in male rats
27. Deleterious effects of prenatal prednisolone exposure upon morphological and behavioral development of mice
28. A placebo-controlled comparison between betamethasone and dexamethasone for fetal maturation: Differences in neurobehavioral development of mice offspring
29. Effect of in utero exposure to betamethasone on motivation/anxiety testing in mice offspring
30. Neurotoxicity of glucocorticoids in the primate brain
31. Cognitive and neurologic development of the premature, small for gestational age infant through age 6: Comparison by birth weight and gestational age
32. Randomized study of the effect of antenatal dexamethasone on growth and development of premature children at the corrected age of 2 years
33. School progress and cognitive development of 6-year-old children whose mothers were treated antenatally with betamethasone
34. Effects of early prenatal dexamethasone on the cognitive and behavioural development of young children: Results of a pilot study
35. Neuronal circuit regulation of the hypothalamo-pituitary-adrenocortical stress axis
36. Central 6-hydroxydopamine lesions decrease mineralocorticoid, but not glucocorticoid receptor gene expression in the rat hippocampus
37. Glucocorticoids and the development of neuronal function: Effects of prenatal dexamethasone exposure on central noradrenergic activity
38. Prenatal dexamethasone exposure alters brain monoamine metabolism and adrenocortical response in rat offspring
39. Programming of brainstem serotonin transporter development by prenatal glucocorticoids
40. Antidepressants and hypothalamic pituitary adrenocortical regulation
41. Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat
42. Maternal glucocorticoid treatment programs HPA regulation in adult offspring: Sex-specific effects
43. Prenatal glucocorticoid modifies hypothalamo-pituitary-adrenal regulation in prepubertal guinea pigs
44. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids
45. Why stress is bad for your brain
46. Hippocampal atrophy in recurrent major depression
47. MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder
48. Hippocampal volume in women victimized by childhood sexual abuse
49. Repeated antenatal corticosteroids: Size at birth and subsequent development
50. Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques. 1. Hippocampus
51. NIH Consensus development conference. Effect of corticosteroids for fetal maturation and perinatal outcomes
52. Adrenal steroids regulate postnatal development of the rat dentate gyrus: 1. Effects of glucocorticoids on cell death
53. Stress, glucocorticoids, and damage to the nervous system: The current state of confusion
54. Repeated prenatal corticosteroids delay myelination in the ovine central nervous system
55. Fetal dexamethasone exposure alters macromolecular characteristics of rat brain development: A critial period for regionally selective alterations?
56. Fetal dexamethasone exposure affects basal ornithine decarboxylase activity in developing rat brain regions and alters acute responses to hypoxia and maternal separation
57. Complex regulation of the expression of the polysialylated form of the neuronal cell adhesion molecule by glucocorticoids in the rat hippocampus
58. Glucocorticoid administration alters nuclear transcription factors in fetal rat brain: Implications for the use of antenatal steroids
59. Can intracellular signalling pathways predict developmental abnormalities? Sensitivity of the adenyl cyclase/c-fos protooncogene cascade to β-adrenergic agonists and glucocorticoids in the fetal rat
60. Neurotropic factors: From molecule to man
61. Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neutrotrophin-3 mRNAs in the hippocampus