Alterations in molecular killing mechanisms: Implications in skin disease

British Journal of Dermatology

Volumn 145, Issue 6, 2001, Pages 868-876

  De Panfilis, G ^a  

^a Clinica Dermatologica Universita   (Italy)

Author keywords

Allergic contact dermatitis; Autoimmune skin disease; Cytolytic T lymphocyte; Killing mechanism; Skin tumour; Viral skin disease

Indexed keywords

ACTIN; ADENOSINE TRIPHOSPHATE; CASPASE 8; CELL RECEPTOR; CYTOTOXIC FACTOR; DEATH RECEPTOR 4; DEATH RECEPTOR 5; FAS LIGAND; FAS RECEPTOR; FLICE INHIBITORY PROTEIN; FRAGMENTIN; GRANZYME A; GRANZYME B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; LAMIN; LYMPHOTOXIN; LYMPHOTOXIN BETA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PERFORIN; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

ANTIBODY PRODUCING CELL; APOPTOSIS; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; CELL SURFACE; CYTOTOXIC T LYMPHOCYTE; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SKIN ALLERGY; SKIN INFLAMMATION; SKIN TUMOR; SYNTHESIS; TARGET CELL DESTRUCTION; VIRUS INFECTION;

AUTOIMMUNE DISEASES; CYTOTOXICITY, IMMUNOLOGIC; CYTOTOXINS; DERMATITIS, ALLERGIC CONTACT; HUMANS; MEMBRANE PROTEINS; SKIN DISEASES; SKIN DISEASES, VIRAL; SKIN NEOPLASMS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035726149     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.2001.04515.x     Document Type: Review

References (101)

1. Social controls on cell survival and cell death
2. Apoptosis and programmed cell death in immunity
3. The Fas death factor
4. Apoptosis in the pathogenesis and treatment of disease
5. Features of target cell lysis by class I and class II MHC-restricted cytolytic T lymphocytes
6. Cytotoxic T lymphocytes: The newly identified Fas (CD95)-mediated killing mechanism and a novel aspect of their biological functions
7. Two distinct pathways of specific killing revealed by perforin mutant cytotoxic T lymphocytes
8. Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity
9. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
10. CTL granules: Evolution of vesicles essential for combating virus infections
11. Cytotoxic T cell responses to intracellular pathogens
12. Perforin is a major contributor to NK cell control of tumor metastasis
13. Perforin: More than just an effector molecule
14. Evidence of a role for TNF-α in cytolysis by CD4+, class II MHC-restricted cytotoxic T cells
15. Processing of tumor necrosis factor-α precursors by metalloproteinases
16. Fas ligand in human serum
17. The transmembrane form of the tumor necrosis factor in the prime activating ligand of the 80 kD tumor necrosis factor receptor
18. Apoptosis by death factor
19. Apoptosis and autoimmune disease
20. Apoptosis: Mechanisms of life and death in the immune system
21. A death-domain-containing receptor that mediates apoptosis
22. Activation of the apoptotic protease CPP32 by cytotoxic T-cell-derived granzyme B
23. Expression of Fas antigen on keratinocytes in vivo and induction of apoptosis in cultured keratinocytes
24. Elevate soluble Fas levels in herpes zoster patients
25. Fas ligand-induced apoptosis as a mechanism of immune privilege
26. Unraveling immune privilege
27. CD95-ligand (Fas-L)-expressing epidermal lymphocytes
28. Basal keratinocytes of normal human skin constitutively express low amounts of CD95-L on the plasma membrane
29. Anti-apoptotic strategies of lymphotropic viruses
30. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors
31. A novel family of viral death effector domain-containing molecules that inhibit both CD-95- and tumor necrosis factor receptor-1-induced apoptosis
32. The host-tumor immune conflict: From immunosuppression to resistance and destruction
33. Distribution of apoptosis-mediating Fas antigen in human skin and effects of anti-Fas monoclonal antibody on human epidermal keratinocyte and squamous cell carcinoma cell lines
34. Discordant expression of Bcl-x and Bcl-2 by keratinocytes in vitro and psoriatic keratinocytes
35. Regression of basal cell carcinoma by intralesional interferon-alpha treatments is mediated by CD95 (Apo-1/Fas)-CD95 ligand-induced suicide
36. Somatic mutations of Fas (Apo-1/CD95) gene in cutaneous squamous cell carcinoma arising from a burn scar
37. Melanoma cell expression of Fas (Apo-1/CD95) ligand: Implications for tumor immune escape
38. Apoptosis, Fas and Fas-ligand expression in melanocytic tumors
39. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells
40. Alterations of Fas (Apo-1/CD95) gene in cutaneous malignant melanoma
41. CD95 and CD95 ligand expression in very thin melanoma
42. Fas and Fas ligand interaction suppress melanoma lung metastasis
43. Inhibition of death receptor signals by cellular FLIP
44. Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells
45. Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma
46. Expression of Fas and Fas ligand in cutaneous B-cell lymphomas
47. Expression of Fas and Fas-ligand in primary cutaneous T-cell lymphoma (CTCL): Association between lack of Fas expression and aggressive types of CTCL
48. Cutaneous T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a Fas-independent pathway for specific tumor cell lysis
49. TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells
50. The Fas counterattack: Cancer as a site of immune privilege
51. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand expressing tumor cells: A mechanism of immune evasion
52. Sunlight-induced basal carcinoma tumor cells and ultraviolet B-irradiated psoriatic plaques express Fas ligand (CD95L)
53. Regulation of CD95 (Apo-1/Fas) ligand and receptor expression in squamous-cell carcinoma by interferon-γ and cisplatin
54. Expression of CD95 ligand in melanocytic lesions as a diagnostic marker
55. Predominant expression of Fas (CD95) ligand in metastatic melanoma revealed by longitudinal analysis
56. Human melanoma reactive CD4+ and CD8+ CTL clones resist Fas ligand-induced apoptosis and use Fas/Fas ligand-independent mechanisms for tumor killing
57. Differential increase of Fas ligand expression on metastatic and thin or thick primary melanoma cells compared with interleukin-10
58. A comparative study of Fas and Fas-ligand expression during melanoma progression
59. Immunoregulatory mechanisms involved in the elicitation of allergic contact hypersensitivity
60. Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis
61. Nickel-specific T lymphocyte clones derived from allergic nickel-contact dermatitis lesions in man: Heterogeneity based on requirement of dendritic antigen-presenting cell subsets
62. Th1 lymphokine production profiles of nickel-specific CD4+ T-lymphocyte clones from nickel contact allergic and nonallergic individuals
63. T cells isolated from positive epicutaneous test reactions to amoxicillin and ceftriaxone are drug specific and cytotoxic
64. Patients with allergic contact dermatitis to nickel and nonallergic individuals display different nickel-specific T cell responses. Evidence for the presence of effector CD8+ and regulatory CD4+ T cells
65. Cytotoxicity is mandatory for CD8+ T cell-mediated contact hypersensitivity
66. Turnover and kinetics of epidermal Langerhans cells and their dendritic precursor cells in experimental contact dermatitis. A correlated ultrastructural-morphometric and immunohistochemical evaluation
67. Effector and regulatory T cells in allergic contact dermatitis
68. Etiopathogenesis of systemic lupus erythematosus
69. Differential control of autoantibodies and lymphoproliferation by Fas ligand expression on CD4+ and CD8+ in vivo
70. Lpr and gld: Single gene models of systemic autoimmunity and lymphoproliferative disease
71. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
72. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity
73. CD8+ cytolytic T lymphocytes and the skin
74. Acquisition of granzyme B and Fas ligand proteins by human keratinocytes contributes to epidermal cell defense
75. Human resting Langerhans cells constitutively bear the Fas-L molecule, but do not express it on the plasma membrane
76. Identification of Fas-L-expressing apoptotic T lymphocytes in normal human peripheral blood: 'In vivo' suicide
77. 'Activation-induced cell death': A special program able to preserve the homeostasis of the skin?
78. Death receptors in cutaneous biology and disease
79. Apoptosis is the mode of keratinocyte death in cutaneous graft-versus-host disease
80. Apoptosis is the predominant form of epithelial target cell injury in acute experimental graft-versus-host disease
81. The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice
82. Fas ligand-mediated killing by intestinal intraepithelial lymphocytes - Participation in intestinal graft-versus-host disease
83. Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin
84. Apoptosis and the skin
85. TRAIL. A molecule with multiple receptors and control mechanisms
86. Exposing tumor cells to killer cell attack
87. Gene transfer of Fas ligand induces tumor regression in vivo
88. Isolation of a lytic, pore-forming protein (perforin) from cytolytic T lymphocytes
89. DNA fragmentation: Manifestation of target cell destruction mediated by cytotoxic T-cell lines, lymphocyte-secreting helper T-cell clones, and cell-free lymphotoxin-containing supernatant
90. Serine esterase in cytolytic T lymphocytes
91. A family of serine esterases in lytic granules of cytolytic T lymphocytes
92. A novel addition to the T cell repertory. Cell surface expression of tumor necrosis factor/cachectin by activated normal human T cells
93. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells
94. Extracellular ATP as a trigger for apoptosis or programmed cell death
95. Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions
96. Identification and functional characterization of a TIA-1-related nucleolysin
97. Regulation of cell surface APO-1/Fas (CD95) ligand expression by metalloproteases
98. Monoclonal antibody-mediated tumor regression by induction of apoptosis
99. Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells
100. CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells
101. B cells in systemic autoimmune disease: Recent insights from Fas-deficient mice and men