Differential inhibition of inflammatory effector functions by petasin, isopetasin and neopetasin in human eosinophils

Clinical and Experimental Allergy

Volumn 31, Issue 8, 2001, Pages 1310-1320

  Thomet, O A R ^a,b,c   Wiesmann, U N ^b   Blaser, K ^a   Simon, H U ^c  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b CH   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

Cellular activation; Eosinophils; Inflammation; Inflammatory mediators; Isopetasin; Neopetasin; Petasin; Signal transduction; Zileuton

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CALCIMYCIN; CALCIUM ION; EOSINOPHIL CATIONIC PROTEIN; ISOPETASIN; LEUKOTRIENE; MITOGEN ACTIVATED PROTEIN KINASE; NEOPETASIN; PETASIN; PHOSPHOLIPASE A2; PLANT EXTRACT; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CALCIUM CELL LEVEL; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; EOSINOPHIL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPECTROFLUOROMETRY; TREATMENT OUTCOME;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARACHIDONATE 5-LIPOXYGENASE; BLOOD PROTEINS; CALCIUM; CELL NUCLEUS; CELLS, CULTURED; COMPLEMENT C5A; CYSTEINE; CYTOPLASM; ENZYME INHIBITORS; EOSINOPHIL GRANULE PROTEINS; EOSINOPHILS; HUMANS; INFLAMMATION; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENES; PHOSPHOLIPASES A; PLATELET ACTIVATING FACTOR; RIBONUCLEASES; SESQUITERPENES;

EID: 0035724638     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2001.01158.x     Document Type: Article

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