Psoriasis vulgaris - A sterile antibacterial skin reaction mediated by cross-reactive T cells? An immunological view of the pathophysiology of psoriasis

Clinical and Experimental Dermatology

Volumn 26, Issue 4, 2001, Pages 326-332

  Prinz, Joerg C ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; BACTERIAL PROTEIN; CYCLOSPORIN A; IMMUNOSUPPRESSIVE AGENT; MONOCLONAL ANTIBODY; TACROLIMUS;

ALLELE; ANTIGEN SPECIFICITY; AUTOIMMUNE DISEASE; CELL DIFFERENTIATION; CROSS REACTION; CYTOKINE RELEASE; DRUG EFFICACY; GENETIC PREDISPOSITION; HLA SYSTEM; HOST RESISTANCE; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KERATINOCYTE; LYMPHOCYTE FUNCTION; MOLECULAR MIMICRY; PATHOGENESIS; PATHOPHYSIOLOGY; PHARYNGITIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN STRUCTURE; PSORIASIS VULGARIS; REVIEW; SKIN MANIFESTATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TREATMENT OUTCOME;

ANTIGENS, BACTERIAL; AUTOIMMUNE DISEASES; CROSS REACTIONS; EPIDERMIS; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LYMPHOCYTE ACTIVATION; MOLECULAR MIMICRY; PSORIASIS; STREPTOCOCCAL INFECTIONS; SUPERANTIGENS; T-LYMPHOCYTES; TONSILLITIS;

EID: 0035723611     PISSN: 03076938     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2230.2001.00831.x     Document Type: Review

References (55)

1. Kinetics of hyperplasia in psoriasis
2. A peptide antibiotic from human skin
3. Mast cell density in psoriatic skin. The effect of PUVA and corticosteroid therapy
4. Immunocompetent cells in psoriasis. In situ immunophenotyping by monoclonal antibodies
5. Structural aspects of initial psoriatic lesions
6. Evolution, maturation, and regression of lesions of psoriasis
7. Genetics of psoriasis
8. Identification of a major susceptibility locus on chromosome 6p and evidence for further disease loci revealed by a two stage genome-wide search in psoriasis
9. Familial juvenile onset psoriasis is associated with the human leukocyte antigen (HLA) class I side of the extended haplotype Cw6-B57-DRB1*0701-DQA1*0201-DQB1*0303: A population- and family-based study
10. Corneodesmosin gene polymorphism demonstrates strong linkage disequilibrium with HLA and association with psoriasis vulgaris
11. Acute guttate psoriasis and streptococcal infection
12. The role of streptococcal infection in the initiation of guttate psoriasis
13. Cyclosporin A for psoriasis
14. Which T cells cause psoriasis?
15. Dermal injection of immunocytes induces psoriasis
16. T cell clones from psoriasis skin lesions can promote keratinocyte proliferation in vitro
17. Kinetics and regulation of human keratinocyte stem cell growth in short-term primary ex vivo culture. Cooperative growth factors from psoriatic lesional T lymphocytes stimulate proliferation among psoriatic uninvolved, but not normal, stem keratinocytes
18. T lymphocytes derived from skin lesions of patients with psoriasis vulgaris express a novel cytokine pattern that is distinct from that of T helper type 1 and T helper type 2 cells
19. Functional diversity of helper T lymphocytes
20. Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis
21. V beta-specific stimulation of human T cells by staphylococcal toxins
22. Bacterial superantigens induce T cell expression of the skin-selective homing receptor, the cutaneous lymphocyte-associated antigen (CLA)
23. Skin-homing T lymphocytes: Detection of cutaneous lymphocyte-associated antigen (CLA) by HECA-452 in normal human skin
24. Skin disease-related T cells bind to endothelial selectins: Expression of cutaneous lymphocyte antigen (CLA) predicts E-selectin but not P-selectin binding
25. Streptococcal skin diseases in children
26. The role of superantigens in skin disease
27. An alpha beta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex
28. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
29. T-cell antigen receptor genes and T-cell recognition
30. Recent advances in understanding V(D)J recombination
31. Antigen-selected T-cell receptor diversity and self-nonself homology
32. + T cells in psoriatic lesions preferentially use T-cell receptor Vβ3 and/or Vβ13.1 genes
33. Evidence for an antigen-specific cellular immune response in skin lesions of patients with psoriasis vulgaris
34. Selection of conserved TCR-VDJ-rearrangements in chronic psoriatic plaques indicates a common antigen in psoriasis vulgaris
35. Clonal characteristics of T cell infiltrates in skin and synovium of patients with psoriatic arthritis
36. Psoriasis: A T-cell-mediated autoimmune disease induced by streptococcal superantigens?
37. Molecular mimicry and autoimmunity
38. Group A streptococcal M proteins: Virulence factors and protective antigens
39. Circulating T cells of patients with active psoriasis respond to streptococcal M-peptides sharing sequences with human epidermal keratins
40. Is an epitope on keratin 17 a major target for autoreactive T lymphocytes in psoriasis?
41. Altered cell-mediated immunity to group A haemolytic streptococcal antigens in chronic plaque psoriasis
42. Streptococcal antigen-specific T lymphocytes in skin lesions of guttate psoriasis
43. T-cell memory: New perspectives
44. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: A geographical view of immune reactivity
45. The instructive role of innate immunity in the acquired immune response
46. Immunology. An affinity for learning
47. Generation and in vivo persistence of polarized Th1 and Th2 memory cells
48. Linear differentiation of cytotoxic effectors into memory T lymphocytes
49. Confrontation between intracellular bacteria and the immune system
50. T cell regulation of the chronic peritoneal neutrophilia during mycobacterial infections
51. Different roles of alpha beta and gamma delta T cells in immunity against an intracellular bacterial pathogen
52. Host-parasite relations in bacterial diseases
53. Bacteriology of pustules occurring during treatment of psoriasis
54. Impaired mast cell-dependent natural immunity in complement C3-deficient mice