Changes in thymic function in HIV-positive patients treated with highly active antiretroviral therapy and interleukin-2

Clinical and Experimental Immunology

Volumn 125, Issue 3, 2001, Pages 440-446

  De Paoli, P ^a   Bortolin, M T ^a   Zanussi, S ^a   Monzoni, A ^b   Pratesi, C ^a   Giacca, M ^b  

^a CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

HIV; Interleukin 2; Lymphocyte subsets; Provirus; Thymus

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; DNA; INDINAVIR; INTERLEUKIN 2; RITONAVIR; SAQUINAVIR; T LYMPHOCYTE RECEPTOR;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; CELL ACTIVITY; CELL COUNT; CELL DIFFERENTIATION; CELL LEVEL; CELL MATURATION; CELL REGENERATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA VIRUS; DOSE RESPONSE; DOSE TIME EFFECT RELATION; FOLLOW UP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; T LYMPHOCYTE; THYMUS FUNCTION; VIREMIA; VIRUS LOAD;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4-CD8 RATIO; DNA, VIRAL; GENE REARRANGEMENT, T-LYMPHOCYTE; HIV SEROPOSITIVITY; HUMANS; INTERLEUKIN-2; MIDDLE AGED; PROVIRUSES; RANDOMIZED CONTROLLED TRIALS; RNA, VIRAL; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; VIRAL LOAD;

EID: 0035716370     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.2001.01615.x     Document Type: Article

References (40)

1. New concepts in the immunopathogenesis of HIV infection
2. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
3. T cell turnover in HIV-1 disease
4. Unraveling the strands of HIV's web
5. HIV-1 replication in patients with undetectable plasma virus receiving HAART. Highly active antiretroviral therapy
6. Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy
7. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy
8. Increases in CD4 T lymphocytes with intermittent courses of interleukin-2 in patients with human immunodeficiency virus infection. A preliminary study
9. A randomized trial of high-versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection
10. Immune reconstitution in HIV infection
11. Immune reconstitution in HIV infection
12. Effects of subcutaneous interleukin-2 therapy on CD4+ subsets and in vitro cytokine production in HIV+ subjects
13. Concomitant therapy with subcutaneous interleukin-2 and zidovudine plus didanosine in patients with early stage HIV infection
14. Kinetics of lymphokine production in HIV+ patients treated with highly active antiretroviral therapy and interleukin 2
15. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection
16. Thymic function can be accurately monitored by the level of recent T cell emigrants in the circulation
17. Direct evidence for thymic function in adult humans
18. Promethean thymus?
19. Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection
20. Changes in thymic function with age and during the treatment of HIV infection
21. Measuring recent thymic emigrants in blood of normal and HIV-1-infected individuals before and after effective therapy
22. Effect of recent thymic emigrants on progression of HIV-1 disease
23. 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults
24. Immunological changes in peripheral blood and in lymphoid tissue after treatment of HIV-infected subjects with highly active anti-retroviral therapy (HAART) or HAART + IL-2
25. Dynamics of HIV-1 mRNA expression in patients with non-progressive HIV-1 infection
26. Dynamics of provirus load and lymphocyte subsets after IL-2 treatment of HIV-infected patients
27. Preferential rearrangements of the T cell receptor-delta-deleting elements in human T cells
28. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans
29. Rapid CD4+ T-cell turnover in HIV-1 infection: A paradigm revisited
30. Naïve T cell division affects the TREC content of naïve T cell population. No evidence for thymic dysfunction in HIV infection
31. Latent reservoirs of HIV infection: Flushing with IL-2?
32. Can IL-2 smoke out HIV reservoirs?
33. Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy
34. Increase of thymic production (TRECs) after adjuvant scIL2 therapy in advanced patients treated by HAART
35. Increased cell division but not thymic dysfunction rapidly affects TRECs content of the naive T cell population in HIV-1 infection
36. Effect of thymectomy on human peripheral blood T cell pools in myasthenia gravis
37. Interconversion of CD45R subsets of CD4 T cells in vivo
38. Peripheral expansion or pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults
39. Quantitative dynamics of HIV-1 expression