Anti-HIV and anti-HBV activity and resistance profile of 2',3'-dideoxy-3'-thiacytidine (3TC) and its arylphosphoramidate derivative CF 1109

Biochemical and Biophysical Research Communications

Volumn 225, Issue 2, 1996, Pages 363-369

  Balzarini, Jan ^a   Wedgwood, O ^b   Kruining, J ^c   Pelemans, Heidi ^a   Heijtink, R ^c   De Clercq, Erik ^a   McGuigan, C ^b  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b CARDIFF UNIVERSITY   (United Kingdom)

^c ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIVIRUS AGENT; LAMIVUDINE; PRODRUG; RNA DIRECTED DNA POLYMERASE; VIRUS ENZYME;

AMINO ACID SEQUENCE; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG POTENCY; DRUG RESISTANCE; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; PRIORITY JOURNAL; VIRUS INHIBITION; VIRUS MUTANT; VIRUS REPLICATION;

HEPATITIS B VIRUS; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 0030583270     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.1996.1181     Document Type: Article

References (17)

1. 1. Coates, J. A. V., Cammack, N., Jenkinson, H. J., Mutton, I. M., Pearson, B. A., Storer, R., Cameron, J. M., and Penn, C. R. (1992) Antimicrob. Agents Chemother. 36, 202-205.
2. 2. Lisignoli, G., Facchini, A., Cattini, L., Monaco, M. C. G., Degrassi, A., and Mariani, E. (1992) Antiviral Chem. Chemother. 3, 299-303.
3. 3. Schinazi, R. F., Chu, C. K., Peck, A., McMillan, A., Mathis, R., Cannon, D., Jeong, L.-S., Beach, J. W., Choi, W.-B., Yeola, S., and Liotta, D. C. (1992) Antimicrob. Agents Chemother. 36, 672-676.
4. 4. Sommadossi, J.-P., Schinazi, R. F., Chu, C. K., and Xie, M.-Y. (1992) Biochem. Pharmacol. 44, 1921-1925.
5. 5. Soudeyns, H., Yao, X.-J., Gao, Q., Belleau, B., Kraus, J.-L., Nguyen-Ba, N., Spira, B., and Wainberg, M. A. (1991) Antimicrob. Agents Chemother. 35, 1386-1390.
6. 6. Gray, N. M., Marr, C. L. P., Penn, C. R., Cameron, J. M., and Bethell, R. C. (1995) Biochem. Pharmacol. 50, 1043-1051.
7. 7. Schinazi, R. F., Lloyd, R. M. Jr., Nguyen, M.-H., Cannon, D. L., McMillan, A., Ilksoy, N., Chu, C. K., Liotta, D. C., Bazmi, H. Z., and Mellors, J. W. (1993) Antimicrob. Agents Chemother. 37, 875-881.
8. 8. Tisdale, M., Kemp, S. D., Parry, N. R., and Larder, B. A. (1993) Proc. Natl. Acad. Sci. USA 90, 5653-5656.
9. 9. Gao, Q., Gu, Z., Parniak, M. A., Cameron, J., Cammack, N., Boucher, C., and Wainberg, M. A. (1993) Antimicrob. Agents Chemother. 37, 1390-1392.
10. 10. Boucher, C. A. B., Cammack, N., Schipper, P., Schuurman, R., Rouse, P., Wainberg, M. A., and Cameron, J. M. (1993) Antimicrob. Agents Chemother. 37, 2231-2234.
11. 11. Balzarini, J., Pelemans, H., Pérez-Pérez, M.-J., San-Félix, A., Camarasa, M.-J., De Clercq, E., and Karlsson, A. (1996) Mol. Pharmacol., in press.
12. 12. Heijtink, R. A., De Wilde, G. A., Kruining, J., Berk, L., Balzarini, J., De Clercq, E., Holý, A., and Schalm, S. W. (1993) Antiviral Res. 21, 141-153.
13. 13. Korba, B. E., and Milman, G. (1991) Antiviral Res. 15, 217-228.
14. 14. Kruining, J., Heijtink, R. A., and Schalm, S. W. (1995) J. Hepatol. 22, 263-267.
15. 15. McGuigan, C., Cahard, D., Sheeka, H. M., De Clercq, E., and Balzarini, J. (1996) J. Med. Chem. 39, 1748-1753.
16. 16. Balzarini, J., Karlsson, A., Aquaro, S., Perno, C.-F., Cahard, D., Naesens, L., De Clercq, E., and McGuigan, C. (1996) Proc. Natl. Acad. Sci. USA, in press.
17. 17. McGuigan, C., Pathirana, R. N., Balzarini, J., and De Clercq, E. (1993) J. Med. Chem. 36, 1048-1052.