The effect of angiogenesis inhibitor TNP-470 against postoperative lung metastasis following removal of orthotopic transplanted human colon cancer: An experimental study

Kurume Medical Journal

Volumn 48, Issue 4, 2001, Pages 285-293

  Oda, Hitoshi ^a   Ogata, Yutaka ^a   Shirouzu, Kazuo ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiogenesis inhibitor; Colon cancer; Orthotopic transplantation; Preclinical lung metastasis model; TNP 470

Indexed keywords

ANGIOGENESIS INHIBITOR; FUMAGILLOL CHLOROACETYLCARBAMATE;

ANGIOGENESIS; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER TRANSPLANTATION; COLON CANCER; CONTROLLED STUDY; GROWTH INHIBITION; HUMAN; HUMAN CELL; LUNG METASTASIS; NONHUMAN; NUDE MOUSE; POSTOPERATIVE PERIOD; RAT;

EID: 0035705786     PISSN: 00235679     EISSN: None     Source Type: Journal    
DOI: 10.2739/kurumemedj.48.285     Document Type: Article

References (23)

1. What is the evidence that tumors are angiogenesis dependent?
2. Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth
3. Regression of metastatic liver tumors in rats treated with angiogenesis inhibitor TNP-470: Occurrence of apoptosis and necrosis
4. Prevention of hepatic metastasis of human colon cancer by angiogenesis inhibitor TNP-470
5. Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo
6. TNP-470 (AGM-1470): Mechanisms of action and early clinical development
7. The effect of TNP-470 on cell proliferation and urokinase-type plasminogen activator and its inhibitor in human lung cancer cells lines
8. Suppressive effect of the angiogenesis inhibitor TNP-470 on the development of carcinogen-induced hepatic nodules in rats
9. Effect of angiogenesis inhibitor TNP-470 on the progression of human gastric cancer xenotransplanted into nude mice
10. Angiocytotoxic therapy in human non-small cell lung cancer cell lines
11. Efficacy of an angiogenesis inhibitor, TNP-470, in xenotransplanted human colorectal cancer with high metastatic potential
12. Comparison of the inhibitory effect of the angiogenesis inhibitor, TNP-470, and mitomycin C on the growth and liver metastasis of human colon cancer
13. Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines
14. Early tumor growth in metastatic organs influenced by the microenvironment is an important factor which provides organ specificity of colon cancer metastasis
15. Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice
16. The pathogenesis of cancer metastasis
17. Induction of angiogenesis during the transition from hyperplasia to neoplasia
18. Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation
19. Mast-cell-deficient W/W mice exhibit a decreased rate of tumor angiogenesis
20. Clinical application of research on angiogenesis
21. Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470. (AGM-1470)
22. Significant inhibition of endothelial cell growth in tumor vasculature by an angiogenesis inhibitor, TNP-470 (AGM- 1470)
23. Pharmacokinetics and metabolism of O-(chloroacetyl-carbamoyl) fumagillol (TNP-470, AGM-1470) in rhesus monkeys