Therapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent

Gene Therapy

Volumn 8, Issue 23, 2001, Pages 1777-1784

  Jeschke, M G ^a,b   Richter, G ^a   Herndon, D N ^b   Geissler, E K ^a   Hartl, M ^a   Hofstatter F ^a   Jauch, K W ^a   Perez Polo, J R ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Gene therapy; Growth factors; KGF; Skin; Thermal injury; Wound healing

Indexed keywords

BETA GALACTOSIDASE; COMPLEMENTARY DNA; KERATINOCYTE GROWTH FACTOR; LIPOSOME; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY SURFACE; BURN; CELL DIVISION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOMEGALOVIRUS; CYTOPLASM; DOSE RESPONSE; DRUG EFFICACY; GENE CONSTRUCT; GENE TRANSFER; GENETIC TRANSFECTION; GRANULATION TISSUE; HISTOLOGY; IN VIVO STUDY; MALE; MARKER GENE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; RAT; SCALD; TREATMENT OUTCOME; WOUND HEALING;

ANIMALS; APOPTOSIS; BURNS; CELL DIVISION; COLLAGEN; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; GENE THERAPY; GENE TRANSFER TECHNIQUES; INSULIN-LIKE GROWTH FACTOR I; LIPOSOMES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SKIN; TRANSFECTION; WOUND HEALING;

ANIMALIA; CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS;

EID: 0035700538     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301589     Document Type: Article

References (47)

1. Optimizing liposome-mediated gene transfer in primary rat septo-hippocampal cell culture
2. Sustained expression of functional nerve growth in primary septo-hippocampal cell cultures by liposome-mediated gene transfer
3. Regional and temporal profiles of c-fos and NGF mRNA expression in rat brain after lateral cortical impact injury in rats
4. Increased expression of BDNF but not NT3 mRNA in rat brain after cortical impact injury
5. Cationic lipid-mediated NGF gene transfection increases neurofilament phosphorylation
6. Insulin-like growth factor-I liposomal gene transfer and systemic growth hormone stimulate wound healing
7. Activation of phosphatidylinositol 3-kinase by brain-derived neurotrophic factor gene transfection in septohippocampal cultures
8. Liposome-mediated NGF gene transfection following neuronal injury: Potential therapeutic applications
9. IGF-I gene transfer in thermal trauma
10. Effect of multiple gene transfers of insulin like growth factor I complementary DNA gene constructs in rats after thermal injury
11. Insulin-like growth factor-I cDNA gene transfer in vitro and in vivo
12. Biodistribution and feasibility of nonviral IGF-I gene transfers in thermally injured skin
13. In vitro studies of liposome-mediated gene transfection
14. Liposomal IGF-I gene transfer modulates pro-and anti-inflammatory cytokine mRNA expression in the burn wound
15. Nonviral skin gene therapy
16. The function of KGF in morphogenesis and reepithelialization of wounds
17. Keratinocyte growth factor: A unique player in epithelial repair processes
18. Keratinocyte growth factor
19. Mutual induction of growth factor gene expression by epidermal-dermal cell interaction
20. Differential expression of keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries
21. Human KGF is FGF-related with properties of paracrine effector of epithelial cells
22. Keratinocyte growth factor protects murine hepatocytes from tumor necrosis-induced apoptosis in vivo and in vitro
23. Modulation of keratinocyte growth factor receptor expression in human cultured keratinocytes
24. Insulin-like growth factor-I and factor-II
25. Circulating levels and molecular distribution of the acid-labile (alpha) subunit of the high molecular weight insulin-like growth factor-binding protein complex
26. Insulin-like growth factor-1 (IGF-I) reduces gut atrophy and bacterial translocation after severe burn injury
27. The effect of insulin-like growth factor-1 on postburn hypermetabolism
28. Insulin-like growth factor-1 as an anabolic agent in catabolic states
29. Combined insulin-like growth factor-1 and growth hormone improves weight loss and wound healing in burned rats
30. Insulin-like growth factor-I plus insulin-like growth factor binding protein-3 affects the hepatic acute phase response and hepatic morphology in thermally injured rats
31. Wound healing-aiming for perfect skin regeneration
32. Growth factors and wound healing
33. Liposome-mediated gene transfer and expression via the skin
34. Nonviral strategies for gene therapy
35. Physical structure and behavior of lipids and lipid enzymes
36. Liposomes
37. Improvements in cationic liposomes for in vivo gene transfer
38. A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung
39. Cationic liposome-mediated gene transfer
40. Biodistribution and gene/expression of lipid/plasmid complexes after systemic administration
41. Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung
42. Cholesterol-containing cationic liposomes attenuate type I acute phase proteins and pro-inflammatory cytokines in thermally injured rats
43. Expression of naked DNA in human, pig and mouse skin
44. Transfection with aFGF cDNA improves wound healing
45. Cutaneous wound healing
46. Development and analysis of a small animal model stimulating the human postburn hypermetabolic response