Immunological characterization of peptide mimetics of carbohydrate antigens in vaccine design strategies

Biologicals

Volumn 29, Issue 3-4, 2001, Pages 249-257

  Monzavi Karbassi, Behjatolah ^a   Cunto Amesty, Gina ^a   Luo, Ping ^a   Lees, Andrew ^b   Kieber Emmons, Thomas ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Biosynexus Inc   (United States)

Author keywords

Antibody response; Carbohydrate; DNA immunization; Peptide mimeotope; T cell response

Indexed keywords

CARBOHYDRATE ANTIGEN; CD5 ANTIGEN; DNA VACCINE; MULTIPLE ANTIGEN PEPTIDE; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ANTIGEN STRUCTURE; BINDING AFFINITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG CROSS REACTIVITY; DRUG DESIGN; DRUG FORMULATION; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOPATHOLOGY; IMMUNOREACTIVITY; MOLECULAR MIMICRY; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; T LYMPHOCYTE ACTIVATION; VACCINATION;

EID: 0035697720     PISSN: 10451056     EISSN: None     Source Type: Journal    
DOI: 10.1006/biol.2001.0307     Document Type: Conference Paper

References (33)

1. Mimotopes: Realization of an unlikely concept
2. Molecular mimetics of polysaccharide epitopes as vaccine candidates for prevention of Neisseria meningitidis serogroup B disease
3. Clinical and immune responses in advanced melanoma patients immunized with an anti-idiotype antibody mimicking disialoganglioside GD2
4. Long survival of patients with small cell lung cancer after adjuvant treatment with the anti-idiotypic antibody BEC2 plus Bacillus Calmette-Guerin
5. Cutting edge: DNA immunization with minigenes of carbohydrate mimotopes induce functional anti-carbohydrate antibody response
6. Cellular cancer vaccine induces delayed-type hypersensitivity reaction and augments antibody response to tumor-associated carbohydrate antigens (sialyl Le(a), sialyl Le(x), GD3 and GM2) better than soluble lysate cancer vaccine
7. T cells activated by zwitterionic molecules prevent abscesses induced by pathogenic bacteria
8. Exploiting molecular mimicry to broaden the immune response to carbohydrate antigens for vaccine development
9. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen
10. Molecular and immunological analysis of genetic prostate specific antigen (PSA) vaccine
11. Peptide mimicry of carbohydrate epitopes on human immunodeficiency virus
12. Antigenic and immunological mimicry of peptide mimotopes of Lewis carbohydrate antigens
13. Vaccination with carbohydrate peptide mimotopes promotes anti-tumour responses
14. B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms
15. Quantitative determination of TCR cross-reactivity using peptide libraries and protein databases
16. Identification of mimicry peptides based on sequential motifs of epitopes derived from 65-kDa glutamic acid decarboxylase
17. Interaction of Brucella abortus lipopolysaccharide with major histocompatibility complex class II molecules in B lymphocytes
18. Immunization with glycosylated Kb-binding peptides generates carbohydrate-specific, unrestricted cytotoxic T cells
19. Peptide anchor residue glycosylation: Effect on class I major histocompatibility complex binding and cytotoxic T lymphocyte recognition
20. Carbohydrate and peptide specificity of MHC class II-restricted T cell hybridomas raised against an O-glycosylated self peptide
21. Crystal structures of two H-2Db/glycopeptide complexes suggest a molecular basis for CTL cross-reactivity
22. Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL
23. T-cell recognition of tumor-associated carbohydrates: The nature of the glycan moiety plays a decisive role in determining glycopeptide immunogenicity
24. Broadly neutralizing antibodies targeted to mucin-type carbohydrate epitopes of human immunodeficiency virus
25. Demonstration of peripheral fucose units in N-linked glycans of human immunodeficiency virus type 1 gp 120: Effects on glycoprotein conformation
26. Cross-recognition by T cells of an epitope shared by two unrelated mycobacterial antigens
27. Binding of multivalent carbohydrates to concanavalin A and Dioclea grandiflora lectin. Thermodynamic analysis of the 'multivalency effect'
28. Immune response to polyvalent melanoma cell vaccine in AJCC stage III melanoma: An immunologic survival model
29. IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxy-nucleotides
30. IFN-gamma is a potent inducer of Ig secretion by sort-purified murine B cells activated through the mIg, but not the CD40, signaling pathway
31. Carbohydrate-dependent, HLA class II-restricted, human T cell response to the bee venom allergen phospholipase A2 in allergic patients
32. Lectin purified human class I MHC-derived peptides: Evidence for presentation of glycopeptides in vivo
33. Mimotopes of cytolytic T lymphocytes in cancer immunotherapy