Mimotopes: Realization of an unlikely concept

Journal of Molecular Recognition

Volumn 13, Issue 6, 2000, Pages 352-359

  Meloen, R H ^a   Puijk, W C ^b   Slootstra, J W ^a  

^a Pepscan Systems   (Netherlands)

^b ID Lelystad BV   (Netherlands)

Author keywords

Antibody; Epitope; Mimotope; Synthetic peptide; Synthetic vaccin

Indexed keywords

DRUG MANUFACTURE; EPITOPE; LIGAND; MIMICRY; MIMOTOPE;

ANIMALS; ANTIGEN-ANTIBODY REACTIONS; DRUG DESIGN; HUMANS; MOLECULAR MIMICRY; PEPTIDE LIBRARY; PEPTIDES;

EID: 0033667160     PISSN: 09523499     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-1352(200011/12)13:6<352::AID-JMR509>3.0.CO;2-C     Document Type: Review

References (72)

1. Peptides reactive with a transmission blocking monoclonal antibody against Plasmodium falciparum Pfs25: 2000-fold affinity increase by PEPSCAN-based amino acid substitutions
2. X-ray diffraction studies of an anti-azophenylarsonate antibody and of an antigen-antibody complex
3. Three-dimensional structure of an antigen-antibody complex at 2.8 A resolution
4. Precise determination of protein antigenic structures has unravelled the molecular immune recognition of proteins and provided a prototype for synthetic mimicking of other protein binding sites
5. Design of peptide enzymes (pepzymes): Surface-simulation synthetic peptides that mimic the chymotrypsin and trypsin active, sites exhibit the activity and specificity of the respective enzyme
6. A proposal for the nomenclature of antigenic sites in peptides and proteins
7. Identification of a hexapeptide that mimics a conformation-dependent binding site of acetylcholine receptor by use of a phage-epitope library
8. Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence
9. Mirhitization of discontinuous antigenic site of foot and mouth disease virus by synthetic peptide constructions
10. Random phage mimotopes recognized by monoclonal antibodies against the pyruvate dehydrogenase complex-E2 (PDC-E2)
11. Peptide mimics of a conformationally constrained protective epitopes of respiratory syncytial virus fusion protein
12. A peptide mimic of a protective epitope of respiratory syncytial virus selected from a combinatorial library induces virus-neutralizing antibodies and reduces viral load in vivo
13. Three-dimensional structure of a complex of antibody with influenza virus neuraminidase
14. Mimotopes identified by phage display for the monoclonal antibody CII-C1 to type II collagen
15. Cyclic peptides as proteases: A reevaluation
16. Peptides on phage: A vast library of peptides for identifying ligands
17. Plant derived vaccine protects target animals against a virus disease
18. Antigenic properties of peptidic mimics for epitopes of the lipopolysaccharide from Brucella
19. Immunogenicity of filamentous phage displaying peptide mimotopes after oral administration
20. Random peptide libraries: A source of specific protein binding molecules
21. Definition of the primary structure of hepatitis B virus (HBV) pre-S hepatocyte binding domain using random peptide libraries
22. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
23. Small peptides induce antibodies with a sequence and structural requirements for binding antigen comparable to antibodies raised against the native protein
24. A priori delineation of a peptide which mimics a discontinuous antigenic determinant
25. Localisation and diagnostic application of immunodominant domains of BFRF3 encoded EBV capsid protein
26. Identification of peptides mimicking the antigenicity and immunogenicity of conformational epitopes on Japanese encephalitis virus protein using synthetic peptide libraries
27. JN: C6 epitope expression by an unrelated antisense cDNA clone: An inadvertent surface-simulation mimotope
28. Identification of a peptide which binds to the carbohydrate-specific monoclonal antibody B3
29. Synergistic effect of immunization with a peptide cocktail inducing antibody, helper and cytotoxic T-cell responses on protection against respiratory syncytial virus
30. Epitope analysis of glycoprotein I of Pseudorabies Virus
31. Allergen mimotopes in food enhance type I allergic reactions in mice
32. Design and immunological properties of topographic immunogenic determinants of a protein antigen (LDHD.C4) as vaccines
33. Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scraple
34. Peptide mimotopes of carbohydrate antigens
35. Vaccination with carbohydrate peptide mimotopes promotes anti-tumor responses
36. A subtype-specific peptide-based enzyme immunoassay for detection of antibodies to the G protein of human respiratory syncytial virus is more sensitive than routine serological tests
37. Full protection in mink against mink enteritis virus wtlh new generation canine parvovirus vaccines based on synthetic peptide or recombinant protein
38. Therapeutic peptides revisited
39. Isolation of sequences from a random-sequence expression library that mimic viral epitopes
40. Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 A
41. Antigenic and Immunological mimicry of peptide mimotopes of Lewis carbohydrate antigens
42. Life cycle patterns and their genetic control: An attempt to reconcile evolutionary and mechanistic speculation
43. Constrained peptide libraries as a tool for finding mimotopes
44. Synthetic peptide vaccines: Success at last
45. PEPSCAN to determine T and B cell epitopes
46. Synthetic peptides for diagnostic use
47. Derivation of vaccines from mimotopes. Immunologic properties of human hepatitis B virus surface antigen mimotopes displayed on filamentous phage
48. Recognition by human sera and immunogenicity of HBsAg mimotopes selected from an M13 phage display library
49. Purification of monoclonal antibodies by epitope and mimotope affinity chromatography
50. Peptide ligands for a sugar-binding protein isolated from a random peptide library
51. Induction of anticarbohydrate antibodies by phage library-selected peptide mimics
52. Peptides that mimic the group B streptococcal type III capsular polysaccharide antigen
53. Selection of antigenic and immunogenic mimics of hepatitis C virus using sera from patients
54. Epitope-specific antibody response to IgE by mimotope immunization
55. Selection of HIV-specific immunogenic epitopes by screening random peptide libraries with HIV-1. Positive sera
56. Effects of monoclonal antibodies to specific epitopes of rat interleukin-1 beta (IL-β) on IL-1β-induced ACTH, corticosterone and IL-6 responses in rats
57. Preclinical test for prion diseases
58. Searching for peptide ligands with an epitope library
59. Three-dimensional structure of an antibody-antigen complex
60. Screening of a small set of random peptides: Anew strategy to identify synthetic peptides that mimic epitopes
61. Mimotope and anti-idiotypic vaccines to induce an anti-IgE response
62. A mimotope from a solid-phase peptide library induces a measles virus neutralizing and protective antibody response
63. Identification of HCV core mimotopes: Improved methods for the selection and use of disease-related phage-displayed peptides
64. Use of a peptide mimotope to guide the humanization of MRK-16, an anti-P-glycoprotein monoclonal antibody
65. Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex
66. Peptide libraries define the fine specificity of antipolysaccharide antibodies to Cryptococcus neoformans
67. Mimotopes, continuous paratopes and hydropathic complementarity; novel approximations in the description of immunochemical speficity
68. From absolute to exquisite specifity. Reflections on the fuzzy nature of species, specifity and antigenic sites
69. Molecular dissection of protein antigens and prediction of epitopes
70. A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin
71. Peptide mimicry of the meningococcal group C capsular polysaccharide
72. Peptide epitopes recognized by a human anti-cryptococcal glucuronoxylomannan antibody