A role for calnexin in the assembly of the MHC class I loading complex in the endoplasmic reticulum

Journal of Immunology

Volumn 166, Issue 3, 2001, Pages 1703-1709

  Diedrich, G ^a   Bangia, N ^a   Pan, M ^a   Cresswell, P ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; CALNEXIN; CALRETININ; CARRIER PROTEIN; CHAPERONE; GLYCAN; GLYCOPROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PEPTIDE; PROTEIN P57; PROTEIN SUBUNIT; PROTEIN TAP; TAPASIN; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOBLAST; CELL SURFACE; CONTROLLED STUDY; DAUDI CELL; ENDOPLASMIC RETICULUM; HELA CELL; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN TRANSPORT;

EID: 0035253721     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.166.3.1703     Document Type: Article

References (34)

1. Mechanisms of MHC class I-restricted antigen processing
2. A critical role for tapasin in the assembly and function of multimeric MHC class I-TAP complexes
3. The thiol oxidoreductase ERp57 is a component of the MHC class 1 peptide-loading complex
4. ER-60, a chaperone with thiol-dependent reductase activity involved in MHC class I assembly
5. A role for the thiol-dependent reductase ERp57 in the assembly of MHC class I molecules
6. The nature of the MHC class I peptide loading complex
7. Species-specific differences in chaperone interaction of human and mouse histocompatibility complex class I molecules
8. Roles for calreticulin and a novel glycoprotein, tapasin, in the interaction of MHC class I molecules with TAP
9. Characteristics of peptide and major histocompatibility complex class I/β2-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2)
10. Nucleotide binding by TAP mediates association with peptide and release of assembled MHC class I molecules
11. MHC class I molecules form ternary complexes with calnexin and TAP and undergo peptide-regulated interaction with TAP via their extracellular domains
12. Deglucosylation of N-linked glycans is an important step in the dissociation of calreticulin-class I-TAP complexes
13. Functional equivalents of interferon-mediated signals needed for induction of an mRNA can be generated by double-stranded RNA and growth factors
14. Soluble tapasin restores MHC class I expression and function in the tapasin negative cell line .220
15. Impaired assembly and transport of HLA-A and -B antigens in a mutant TxB cell hybrid
16. Functional expression and purification of the ABC transporter complex associated with antigen processing (TAP) in insect cells
17. Use of monoclonal antibody (w6/32) in structural studies of HLA-A, B, C antigens
18. Monoclonal antibodies raised against denatured HLA-B locus H-chains permit biochemical characterization of certain HLA-C locus products
19. Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T-cell and B-cell antigen receptors and major histocompatibility complex antigens during their assembly
20. Monoclonal antibodies to the human multicatalytic proteinase (proteasome)
21. 2-microglobulin complexes associate with TAP transporters before peptide binding
22. The N-terminal region of tapasin is required to stabilize the MHC class I loading complex
23. Quality control in the secretory pathway: Retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment and Golgi apparatus
24. 2-microglobulin, class I heavy chain conformation, and tapasin in the interactions of class I heavy chain with calreticulin and the transporter associated with antigen processing
25. Interaction of the thiol-dependent reductase ERp57 with nascant glycoproteins
26. The thiol-dependent reductase ERp57 interacts specifically with N-glycosylated integral membrane proteins
27. Enhanced catalysis of ribonuclease B folding by the interaction of calnexin or calreticulin with ERp57*
28. Identification of the region of the class I histocompatibility molecule that interacts with the molecular chaperone p88 (calnexin, IP90)
29. The role of ERp57 in disulfide bond formation during the assembly of major histocompatibility complex class I in a synchronized semipermeabilized cell translation system
30. 2 microglobulin in the intracellular transport and surface expression of murine class I histocompatibility molecules
31. Allele-specific differences in the interaction of MHC class I molecules with transporters associated with antigen processing
32. HLA-A2 molecules in an antigen-processing mutant cell contain signal sequence-derived peptides
33. Assembly, peptide loading, and transport of MHC class I molecules in a calnexin-negative cell line
34. MHC class I expression and transport in a calnexin-deficient cell line