Antioxidative effects of fluvastatin and its metabolites against oxidative DNA damage in mammalian cultured cells

Free Radical Research

Volumn 35, Issue 6, 2001, Pages 789-801

  Imaeda, Atsumune ^a   Tanigawa, Toru ^b   Aoki, Tomonori ^a   Kondo, Yasushi ^a   Nakamura, Naoto ^b   Yoshikawa, Toshikazu ^b  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Antioxidant; Electron spin resonance; Fluvastatin; Oxidative DNA damage; Reactive oxygen species; Single cell gel electrophoresis assay

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; DNA; DRUG METABOLITE; FERROUS GLUCONATE; FLUINDOSTATIN; HYDROGEN PEROXIDE; HYDROXYL RADICAL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOXANTHINE; PRAVASTATIN; PROBUCOL; REACTIVE OXYGEN METABOLITE; SIMVASTATIN; SUPEROXIDE; TERT BUTYL HYDROPEROXIDE; TROLOX C; XANTHINE OXIDASE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER; CELL AGING; CELL PROTECTION; CHINESE HAMSTER; CONTROLLED STUDY; DIABETES MELLITUS; DNA DAMAGE; DRUG POTENCY; DRUG STRUCTURE; ELECTRON SPIN RESONANCE; GEL ELECTROPHORESIS; IN VITRO STUDY; INFLAMMATION; MAMMAL CELL; NEWBORN; NONHUMAN; OXIDATIVE STRESS; SCAVENGING SYSTEM;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; MAMMALIA;

EID: 0035692711     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760100301291     Document Type: Article

References (36)

1. "Reduced susceptibility of low density lipoprotein (LDL) to lipid peroxidation after fluvastatin therapy is associated with the hypocholesterolemic effect of the drug and its binding to the LDL"
2. "Effects of fluvastatin therapy on lipids, antioxidants, oxidation of low density lipoproteins and trace metals"
3. "Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition"
4. "Fluvastatin - A review of its pharmacology and use in the management of hypercholesterolaemia"
5. "Biotransformation of fluvastatin sodium in humans"
6. "Inhibitory effects of fluvastatin, a new HMG-CoA reductase inhibitor, on the increase in vascular ACE activity in cholesterol-fed rabbits"
7. "Protective effect of fluvastatin sodium (XU-62-320), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, on oxidative modification of human low-density lipoprotein in vitro"
8. "Protective effects of fluvastatin against reactive oxygen species induced DNA damage and mutagenesis"
9. "Effects of antioxidants on the mutagenicity of reactive oxygen species-generating systems towards Salmonella typhimurium TA102 and TA104 strains"
10. "An in vitro study of the hydroxyl radical scavenging property of fluvastatin, an HMG-CoA reductase inhibitor"
11. "Superoxide anion scavenging properties of fluvastatin and its metabolites"
12. "The single cell gel electrophoresis assay (comet assay): A European review"
13. "The comet assay: A comprehensive review"
14. "Genotoxic effects of chemicals in the single cell gel (SCG) test with human blood cells in relation to induction of sister chromatid exchanges (SCE)"
15. "Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing"
16. "A simple technique for quantitation of low levels of DNA damage in individual cells"
17. "Antioxidant properties of bromocriptine, a dopamine agonist"
18. "Measurement of superoxide dismutase activity by electron spin resonance"
19. "Determination of hydroxyl radical scavenging activity by electron spin resonance"
20. "The single cell gel electrophoresis assay for induced DNA damage (comet assay): Measurement of tail length and moment"
21. "Mechanism of antioxidative activity of fluvastatin-determination of the active position"
22. "Antioxidative effects of fluvastatin, and its major metabolites"
23. "Fluvastatin, an inhibitor of 3-hydroxy-3-methylglutaryl CoA reductase, scavenges free radicals and inhibits lipid peroxidation in rat liver microsomes"
24. "The use of single cell electrophoresis assay in detecting DNA single strand breaks in lung cells in vitro"
25. "Dietary carcinogens and anticarcinogens"
26. "The effect of vitamin C supplementation on biomarkers of oxygen radical generated damage in human volunteers with low or high cholesterol levels"
27. "Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer"
28. "Oxidative stress and diabetes mellitus: A possible role of alpha-dicarbonyl compounds in free radical formation"
29. "The association between the total antioxidant potential of plasma and the presence of coronary heart disease and renal dysfunction in patients with NIDDM"
30. "Effect of anticancer drugs, metals and antioxidants on cytotoxic activity of epigallocatechin gallate"
31. "Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events"
32. "Significant inhibition by the flavonoid antioxidant silymarin against 12-O-tetradecanoylphorbol 13-acetate-caused modulation of antioxidant and inflammatory enzymes, and cyclooxygenase 2 and interleukin-1alpha SENCAR mouse epidermis: Implications in the prevention of stage I tumor promotion"
33. "Carotenoids and cancer: Prevention and potential therapy"
34. "The antioxidant/anticancer potential of phenolic compounds isolated from olive oil"
35. "Probucol scavenged 1,1-diphenyl-2-picrylhydrazyl radicals and inhibited formation of tiobarbituric acid reactive substances"
36. "Free radical intermediates during peroxidation of 2-t-butyl-4-methoxyphenol, 2,6-di-t-butyl-4-methylphenol, and related phenol compounds"