Mechanism of antioxidative activity of fluvastatin-determination of the active position

Chemical and Pharmaceutical Bulletin

Volumn 48, Issue 2, 2000, Pages 235-237

  Nakamura, Takashi ^a   Nishi, Hiroyuki ^a   Kokusenya, Yoshio ^a   Hirota, Kenichi ^b   Miura, Yozo ^b  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b Osaka Prefecture University   (Japan)

Author keywords

3 hydroxy 3 methylglutaryl coenzyme A reductase inhibitor; Antioxidative activity; Fluvastatin; Hydrogen atom abstraction; Spin trapping

Indexed keywords

FLUINDOSTATIN;

ANTIOXIDANT ACTIVITY; ARTICLE; DRUG STRUCTURE; OXIDATIVE STRESS; SPIN TRAPPING;

EID: 0034056119     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.48.235     Document Type: Article

References (19)

1. Tsujita S., PROTEIN, NUCLEIC ACID AND ENZYME, 38, 1919 (1993).
2. Tabe K., Medicine and Drug Journal, 29, 2146 (1993).
3. The Pravastatin Multinational Study Group for Cardiac Risk Patients, Am. J. Cardiol., 72, 1031 (1993).
4. Koide M., Kawahara Y., Medicine and Drug Journal, 32, 2965 (1996).
5. Gotoh N., Shimizu K., Komuro E., Tsuchiya J., Noguchi N., Niki E., Biochim. Biophys. Acta, 1128, 147 (1992).
6. Noguchi N., Gotoh N., Niki E., Biochim. Biophys. Acta, 1213, 176 (1994).
7. Mitani H., Bandoh T., Ishikawa J., Kimura M., Totsuka T., Hayashi S., Br. J. Pharmacol., 119, 1269 (1996).
8. Leonhardt W., Kurktschiev T., Meissner D., Lattke P., Abletshauser C., Weidinger G., Jaross W., Hanefeld M., Eur . J. Clin. Pharmacol., 53, 65 (1997).
9. Hussein O., Schlezinger S., Rosenblat M., Keidar S., Aviram M., Arterosclerosis, 128, 11, (1997).
10. Herd J. A., Ballantyne C. M., Farmer J. A., Ferguson J. J., Jones P. H., West M. S., Gould K. L., Gottor A. M., Jr., Am. J. Cardiol., 80, 278-286 (1997).
11. Yamamoto A., Hoshi K., Ichihara K., Eur. J. Pharm., 361, 143 (1998).
12. Nakashima A., Ohtawa M., Masuda N., Morikawa H., Bando T., Yakugaku Zasshi, 119, 93 (1999).
13. Suzumura K., Yasuhara M., Tanaka K., Odawara A., Narita H., Suzuki T., Chem. Pharm. Bull., 47, 1010 (1999).
14. Bartlett P. D., Benzing E. P., Pincock R. E., J. Am. Chem. Soc., 82, 1762 (1960).
15. FLV-Me is soluble in benzene, different from FLV.
16. Niki E., Yokoi S., Tsuchiya J., Kamiya Y., J. Am. Chem. Soc., 105, 1498 (1983).
17. DBDP is rapidly decomposed by an ionic mechanism in polar solvents such as methanol. 14)
18. Miura Y., Masuda S., Kinoshita M., Macromol. Chem., 160, 243 (1972).
19. The concentration of TEMPO was constant during the reaction, in agreement with the ESR results mentioned above.