Mutant Models of Prolonged Life Span

Toxicologic Pathology

Volumn 29, Issue 6, 2001, Pages 673-676

  Mahler, Joel F ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; EVOLUTION; GENETIC ANALYSIS; LIFESPAN; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SACCHAROMYCES CEREVISIAE; THEORY;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; LONGEVITY; MICE; MODELS, BIOLOGICAL; MUTATION;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; MAMMALIA; MELANOGASTER; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0035678855     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/019262301753386013     Document Type: Article

References (31)

1. Brown-Borg HM, Borg KE, Meliska CJ, Bartke A. (1996). Dwarf mice and the ageing process. Nature 384: 33.
2. Clancy DJ, Gems D., Harshman LG, Oldham S., Stocker H., Hafen E., Leevers SJ, Partridge L. (2001). Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292: 104-106.
3. Coschigano KT, Clemmons D., Bellush LL, Kopchick JJ (2000). Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141: 2608-2613.
4. Farlie PG, Dringen R., Rees SM, Kannouraki s G., Bernard O. (1995). Bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc Natl Acad Sci USA 92: 4397-4401.
5. Ho Y-S., Magnanet J-L., Gargano M., Cao J. (1998). The nature of antioxidant defense mechanisms: A lesson from transgenic studies. Environ Health Perspect 106 (Suppl 5): 1219-1228.
6. Jazwinski SM (1996). Longevity, genes, and aging. Science 273: 54-59.
7. Jazwinski SM (2000). Metabolic control and gene dysregulation in yeast aging. Ann NY Acad Sci 908: 21-30.
8. Kennedy BK, Austriaco NR, Zhang J., Guarente L. (1995). Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80: 485-496.
9. Kirkwood TBL (2000). Molecular gerontology-bridgin g the simple and the complex. Ann NY Acad Sci 908: 14-20.
10. Kuro-o M., Matsumara Y., Aizawa H., Kawaguchi H., Suga T., Utsugi T., Ohyama Y., Kurabayashi M., Kaname T., Kume E., Iwasaki H., Iida A., Shiraki-Lida T., Nishikawa S., Nagai R., Nabeshima Y. (1997). Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51.
11. Lin S-J., Defossez P-A., Guarente L. (2000). Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126-2128.
12. Lin Y-J., Seroude L., Benzer S. (1998). Extended life-span and stress resistance in the Drosophila mutant methusaleh. Science 282: 943-946.
13. Lithgow GJ, Kirkwood TBL (1996). Mechanisms and evolution of aging. Science 273: 80.
14. Martin GM, Austad SN, Johnson TE (1996). Genetic analysis of ageing: Role of oxidative damage and environmental stresses. Nature Genetics 13: 25-34.
15. Masoro EJ (1996). Possible mechanisms underlying the antiaging actions of caloric restriction. Toxicol Pathol 24: 738-741.
16. Melov S. (2000). Mitochondrial oxidative stress. Physiologic consequences and potential for a role in aging. Ann NY Acad Sci 908: 219-225.
17. Merry BJ (2000). Calorie restriction and age-related oxidative stress. Ann NY Acad Sci 908: 180-198.
18. Migliaccio E., Giorgio M., Mele S., Pelicci G., Reboldi P., Pandolfi PP, Lanfrancone L., Pelicci PG (1999). The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402: 309-313.
19. Murakami S., Tedesco PM, Cypser JR, Johnson TE (2000). Molecular genetic mechanisms of life span manipulation in Caenorhabditis elegans. Ann NY Acad Sci 908: 40-49.
20. Orr WC, Sohal RS (1994). Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263: 1128-1130.
21. Parr T. (1997). Insulin exposure and aging theory. Gerontology 43: 182-200.
22. Rogina B., Reenan RA, Nilsen SP, Helfand SL (2000). Extended life-span conferred by co-transporter gene mutations in Drosophila. Science 290: 2137-2140.
23. Slagboom PE, Bastiaan TH, Beekman M., Westendorp RGP, Meulenbelt I. (2000). Genetics of human aging. The search for genes contributing to human longevity and diseases of the old. Ann NY Acad Sci 908: 50-63.
24. Smith JR, Pereira-Smith OM (1996). Replicative senescense: implications for in vivo aging and tumor suppression. Science 273: 63-67.
25. Sohal RS, Weindruch R. (1996). Oxidative stress, caloric restriction, and aging. Science 273: 59-63.
26. Strauss E. (2001). Growing old together. Science 292: 41-43.
27. Takeda T., Shimizu K., Chen W-H. (1996). Amyloid arthropathy and degenerative joint disease in the senescence-accelerate d mouse (SAM). In: Pathobiology of the Aging Mouse, Vol. II, Mohr U, Dungworth DL, Capen CC, Carlton WW, Sundberg JP, Ward JM (eds). ILSI Press, Washington DC, pp 455-471.
28. Tatar M., Kopelman A., Epstein D., Tu M-P., Yin C-M., Garofalo RS (2001). A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292: 107-110.
29. Tissenbaum HA, Guarente L. (2001). Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230.
30. von Zglinicki T. (2000). Role of oxidative stress intelomerelengthregulation and replicative senescence. Ann NY Acad Sci 908: 99-110.
31. Zurcher C., Slagboom P. (1994). Basic aspects of aging. In: Pathobiology of the Aging Rat, Vol. II, Mohr U, Dungworth DL, Capen CC (eds). ILSI Press, Washington DC, pp 573-586.