Molecular genetic mechanisms of life span. Manipulation in Caenorhabditis elegans

Annals of the New York Academy of Sciences

Volumn 908, Issue , 2000, Pages 40-49

  Murakami, Shin ^a,b   Tedesco, Patricia M ^a   Cypser, James R ^a   Johnson, Thomas E ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; TRANSCRIPTION FACTOR;

AGING; CAENORHABDITIS ELEGANS; CONFERENCE PAPER; GONAD; LIFESPAN; LONGEVITY; MOLECULAR GENETICS; NERVE CELL; NONHUMAN; SIGNAL TRANSDUCTION; STRESS;

CAENORHABDITIS ELEGANS;

EID: 0033929127     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06634.x     Document Type: Conference Paper

References (61)

1. 1. MARTIN, G.M. et al. 1996. Genetic analysis of aging: role of oxidative damage and environmental stresses. Nat. Genet. 13: 25-34.
2. 2. JOHNSON, T.E. et al. 1996. Hypothesis: interventions that increase the response to stress offer the potential for effective life prolongation and increased health. J. Gerontol. 51: B392-B395.
3. 3. JOHNSON, T.E. & G.J. LITHGOW. 1992. The search for the genetic basis of aging: the identification of gerontogenes in the nematode Caenorhabditis elegans. J. Am. Geriatr. Soc. 40: 936-945.
4. 4. RATTAN, S.I. 1998. The nature of gerontogenes and vitagenes. Antiaging effects of repeated heat shock on human fibroblasts. Ann. N.Y. Acad. Sci. 854: 54-60.
5. 5. WOOD, W.B. 1998. Aging of Caenorhabditis elegans: mosaics and mechanisms. Cell 95: 147-150.
6. 6. JOHNSON, F.B. et al. 1999. Molecular biology of aging. Cell 96: 291-302.
7. 7. LITHGOW, G.J. & T.B.L. KIRKWOOD. 1996. Mechanisms and evolution of aging. Science 273: 80.
8. 8. MURAKAMI, S. & T.E. JOHNSON. 1996. A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 143: 1207-1218.
9. 9. JOHNSON, T.E. & W.B. WOOD. 1982. Genetic analysis of life-span in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 79: 6603-6607.
10. 10. JOHNSON, T.E. 1987. Aging can be genetically dissected into component processes using long-lived strains of C. elegans. Proc. Natl. Acad. Sci. USA 84: 3777-3781.
11. 11. EBERT, R.H. et al. 1996. Defining genes that govern longevity in Caenorhabditis elegans. Dev. Genet. 18: 131-143.
12. 12. SHOOK, D.R. et al. 1996. Mapping quantitative trait loci affecting life history traits in the nematode Caenorhabditis elegans. Genetics 142: 801-817.
13. 13. SHOOK, D.R. & T.E. JOHNSON. 1999. Quantitative trait loci affecting survival and fertility-related traits in Caenorhabditis elegans show genotype-environment interactions, pleiotropy, and epistasis. Genetics 153: 1233-1243.
14. 14. KLASS, M.R. 1983. A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results. Mech. Ageing Dev. 22: 279-286.
15. 15. FRIEDMAN, D.B. & T.E. JOHNSON. 1988. A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility. Genetics 118: 75-86.
16. 16. DUHON, S.A. et al. 1996. Direct isolation of longevity mutants in the nematode Caenorhabditis elegans. Dev. Genet. 18: 144-153.
17. 17. YANG, Y.L. & D.L. WILSON. 1999. Characterization of a life-extending mutation in age-2, a new aging gene in Caenorhabditis elegans. J. Gerontol. 54: B137-B142.
18. 18. ANDERSON, P. 1995. Caenorhabditis elegans: modern biological analysis of an organism. Meth. Cell Biol. 48: 31-58.
19. 19. JANSEN, G. et al. 1997. Reverse genetics by chemical mutagenesis in Caenorhabditis elegans. Nat. Genet. 17: 119-121.
20. 20. JOHNSON, T.E. 1990. Increased life-span of age-1 mutants in Caenorhabditis elegans and lower Gompertz rate of aging. Science 249: 908-912.
21. 21. MALONE, E. et al. 1996. Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation. Genetics 143: 1193-1205.
22. 22. RIDDLE, D.L. & P.S. ALBERT. 1997. Genetic and environmental regulation of dauer larva development. C. elegans II. 739-768.
23. 23. LARSEN, P.L. 1993. Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 90: 8905-8909.
24. 24. VANFLETEREN, J.R. 1993. Oxidative stress and ageing in Caenorhabditis elegans. Biochem. J. 292: 605-608.
25. 25. LITHGOW, G.J. et al. 1994. Thermotolerance of a long-lived mutant of Caenorhabditis elegans. J. Gerontol. Biol. Sci. 49: B270-B276.
26. 26. LITHGOW, G.J. et al. 1995. Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc. Natl Acad. Sci. USA 92: 7540-7544.
27. 27. MELOV, S. et al. 1995. Increased frequency of deletions in the mitochondrial genome with age of Caenorhabditis elegans. Nucleic Acids Res. 23: 1419-1425.
28. 28. LARSEN, P.L. et al. 1995. Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139: 1567-1583.
29. 29. MORRIS, J.Z. et al. 1996. A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382: 536-539.
30. 30. KENYON, C. et al. 1993. A C. elegans mutant that lives twice as long as wild type. Nature 366: 461-464.
31. 31. KIMURA, K. et al. 1997. daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277: 942-946.
32. 32. DORMAN, J.P. et al. 1995. The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans. Genetics 141: 1399-1406.
33. 33. OGG, S. et al. 1997. The fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in Caenorhabditis elegans. Nature 389: 994-999.
34. 34. LIN, K. et al. 1997. daf-16: An HNF-3-forkhead family member that can function to double the lifespan of Caenorhabditis elegans. Science 278: 1319-1322.
35. 35. PARADISE, S. et al. 1999. A PDK homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans. Genes Dev. 13: 1438-1452.
36. 36. ALLION, M. et al. 1999. Neurosecretory control of aging in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 96: 7394-7397.
37. 37. APFELD, J. & C. KENYON. 1998. Cell nonautonomy of Caenorhabditis elegans daf-2 function in the regulation of diapause and life span. Cell 95: 199-210.
38. 38. PARADISE, S. & G. RUVKUN. 1998. Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinae to the DAF-16 transcription factor. Genes Dev. 12: 2488-2498.
39. 39. OGG, S. & G. RUVKUN. 1998. The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway. Mol. Cell 2: 887-893.
40. 40. ROUAULT, J.P. et al. 1999. Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN. Curr. Biol. 25: 329-332.
41. 41. VANVOORHIES, W.A. 1992. Production of sperm reduces nematode life span. Nature 360: 456-458.
42. 42. GEMS, D. & D. RIDDLE. 1996. Longevity in Caenorhabditis elegans reduced by mating but not gamete production. Nature 379: 723-725.
43. 43. CYPSER, J.R. & T.E. JOHNSON. 1999. The spe-10 has longer life and increased stress resistance. Neurobiol. Aging 20: 503-512.
44. 44. WONG, A. et al. 1995. Mutants in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing. Genetics 139: 1247-1259.
45. 45. EWBANK, J.J. et al. 1997. Structural and functional conservation of the Caenorhabditis elegans timing gene clk-1. Science 275: 980-983.
46. 46. LAKOWSKI, B. & S. HEKIMI. 1996. Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272: 1010-1013.
47. 47. TAUB, J. et al. 1999. A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants. Nature 13: 162-166.
48. 48. LAKOWSKI, B. & S. HEKIMI. 1998. The genetics of caloric restriction in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 95: 3091-3096.
49. 49. HSIN, H. & C. KENYON. 1999. Signals from the reproductive system regulate the lifespan of C. elegans. Nature 27: 362-366.
50. 50. MELLO, C.C. et al. 1991. Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10: 3959-3970.
51. 51. MURAKAMI, S. & T.E. JOHNSON. 1998. Life extension and stress resistance in Caenorhabditis elegans modulated by the tkr-1 gene. Curr. Biol. 8: 1091-1094.
52. 52. HONDA, S. & Y. HONDA. 1999. The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans. FASEB J. 13: 1385-1395.
53. 53. KENYON, C. 1994. Ponce d'elegans: genetic quest for the fountain of youth. Cell 84: 501-504.
54. 54. GUARENTE, L. 1997. Aging. What makes us tick? Science 275: 943-944.
55. 55. JONASSEN, T. et al. 1998. Yeast clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis. J. Biol. Chem. 273: 3351-3357.
56. 56. FELKAI, S. et al. 1999. CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans. EMBO J. 18: 1783-1792.
57. 57. BRECKMAN, B.P. et al. 1999. Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans. Curr. Biol. 9: 493-496.
58. 58. VANFLETEREN, J.R. & A. DE VREESE. 1996. A rate of aerobic metabolism and superoxide production rate potential in the nematode Caenorhabditis elegans. J. Exp. Zool. 274: 93-100.
59. 59. VAN VOORHIES, W.A. & S. WARD. 1999. Genetic and environmental conditions that increase longevity in Caenorhabditis elegans decrease metabolic rate. Proc. Natl. Acad. Sci. USA 96: 11399-11403.
60. 60. LEE, C.K. et al. 1999. Gene expression profile of aging and its retardation by caloric restriction. Science 285: 1390-1393.
61. 61. KURTZ, S. et al. 1986. An ancient developmental induction: heat-shock proteins induced in sporulation and oogenesis. Science 231: 1154-1157.