Caspase-dependent deubiquitination of monoubiquitinated nucleosomal histone H2A induced by diverse apoptogenic stimuli

Cell Death and Differentiation

Volumn 8, Issue 12, 2001, Pages 1182-1196

  Mimnaugh, E G ^a   Kayastha, G ^a   McGovern, N B ^a   Hwang, S G ^a   Marcu, M G ^a   Trepel, J ^a   Cai, S Y ^b   Marchesi, V T ^b   Neckers, L ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Caspases; Deubiquitination; Histones; Nucleosomes; Ubiquitin

Indexed keywords

CASPASE; CASPASE INHIBITOR; DOXORUBICIN; ETOPOSIDE; FAS ANTIBODY; HISTONE H2A; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEASOME INHIBITOR; PROTEIN BCL XL; STAUROSPORINE; UBIQUITIN;

APOPTOSIS; ARTICLE; CELL DIVISION; CHROMATIN CONDENSATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE MUTATION; GENETIC CODE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MITOSIS; MOLECULAR WEIGHT; NUCLEOSOME; PRIORITY JOURNAL; PROTEIN DEGRADATION;

APOPTOSIS; BCL-X PROTEIN; CASPASE 3; CASPASES; CELL MEMBRANE; CELLS, CULTURED; CHROMATIN; DOXORUBICIN; GENE EXPRESSION; HISTONES; NUCLEOSOMES; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSFECTION; UBIQUITINS;

EID: 0035674618     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4400924     Document Type: Article

References (46)

1. Ubiquitinated histone H2B is preferentially located in transcriptionally active chromatin
2. Level of ubiquitinated histone H2B in chromatin is coupled to ongoing transcription
3. Effects of histone acetylation, ubiquitination and variants on nucleosome stability
4. Metabolism of ubiquitinated histones
5. Rapid turnover of the histone-ubiquitin conjugate, protein A24
6. Exchange of histones H1, H2A, and H2B in vivo
7. Identification of ubiquitinated histones 2A and 2B in Physarum polycephalum
8. Reversible histone modifications and the chromosome cell cycle
9. A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division
10. Disappearance of ubiquitinated histone H2A during chromatin condensation in TGFB1-induced apoptosis
11. Peptidyl aldehyde inhibitors of proteasome induce apoptosis rapidly in mouse lymphoma RVC cells
12. Rapid deubiquitination of nucleosomal histones in human tumor cells caused by proteasome inhibitors and stress response inducers: Effects on replication, transcription, translation, and the cellular stress response
13. Prevention of cisplatin-DNA adduct repair and potentiation of cisplatin-induced apoptosis in ovarian carcinoma cells by proteasome inhibitors
14. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
15. The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7
16. The Bcl-2 protein family: Arbiters of cell survival
17. Bcl-2 proteins: Regulators of apoptosis or of mitochondrial homeostasis?
18. The Bcl-2 protein family
19. Bcl-xL does not inhibit the function of Apaf-1
20. Apoptosis of Ewing’s sarcoma cells is accompanied by accumulation of ubiquitinated proteins
21. Sodium butyrate induces apoptosis and accumulation of ubiquitinated proteins in human breast carcinoma cells
22. Functional diversity among putative E2 isozymes in the mechanism of ubiquitin-histone ligation
23. The ubiquitin system
24. Regulation of ubiquitin-dependent processes by deubiquitinating enzymes
25. Deubiquitinating enzymes: A new class of biological regulators
26. Disappearance of a structural chromatin protein A24 in mitosis: Implications for molecular basis of chromatin condensation
27. Affinity of chromatin constituents for isopeptidase
28. Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis
29. Caspases: The executioners of apoptosis
30. Caspase structure, proteolytic substrates, and function during apoptotic cell death
31. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
32. Aggresomes: A cellular response to misfolded proteins
33. Aggresomes, inclusion bodies and protein aggregation
34. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
35. The DNA repair protein Rad23 is a negative regulator of multi-ubiquitin chain assembly
36. BCA protein assay
37. Electrophoretic transfer of proteins form polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
38. Enhancement of immunoblot sensitivity by heating of hydrated filters
39. Catalyzed reporter disposition, a novel method of signal amplification
40. Western blotting and immunochemical detection of histones electrophoretically resolved on acid-urea-triton-and sodium dodecyl sulfate-polyacrylamide gels
41. The measurement of ubiquitin and ubiquitinated proteins
42. Resolution of histones by polyacrylamide gel electrophoresis in presence of nonionic detergents
43. The ubiquitinated histone species are enriched in histone H1-depleted chromatin regions
44. DNA double-strand breaks induce histone H2AX phosphorylation on serine 139
45. Microfluorometric investigations of chromatin structure. I. Evaluation of nine DNA-specific fluorochromes as probes of chromatin organization
46. Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells