Functional inhibition of CCR3-dependent responses by peptides derived from phage libraries

European Journal of Immunology

Volumn 31, Issue 12, 2001, Pages 3535-3545

  Houimel, Mehdi ^a   Loetscher, Pius ^b   Baggiolini, Marco ^b   Mazzucchelli, Luca ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Antagonist; CCR3; Eotaxin; Peptide; Phage display

Indexed keywords

CALCIUM ION; CHEMOKINE RECEPTOR CCR3; CHEMOKINE RECEPTOR CXCR1; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR5; EOTAXIN; HEXAPEPTIDE; IODINE 125; LIGAND; PEPTIDE LIBRARY; SYNTHETIC PEPTIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CELL MIGRATION; CHEMOTAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; EXPOSURE; GENETIC TRANSFECTION; ISOTOPE LABELING; MOUSE; NONHUMAN; PHAGE DISPLAY; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PURIFICATION; RECEPTOR BINDING;

ANIMALS; CALCIUM; CHEMOKINES, CC; MICE; PEPTIDE LIBRARY; RECEPTORS, CHEMOKINE;

EID: 0035667313     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-4141(200112)31:12<3535::AID-IMMU3535>3.0.CO;2-3     Document Type: Article

References (32)

1. Blood and bronchoalveolar eosinophils in allergic subjects after segmental antigen challenge: Surface phenotype, density heterogeneity, and prostanoid production
2. Mechanisms of mucosal inflammation in the nose and lungs
3. Pathogenesis of atopic dermatitis
4. Allergy and the gut
5. Do eosinophils have a role in the killing of helminth parasites?
6. Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemo-attractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (Intrinsic) asthmatics
7. Selective expression of the eotaxin receptor CCR3 by human T helper 2 cells
8. Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils
9. High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines
10. Tryptase-chymase double-positive human mast cells express the eotaxin receptor CCR3 and are attracted by CCR3-binding chemokines
11. Targeted disruption of the chemokine eotaxin partially reduces antigen-induced tissue eosinophilia
12. Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody
13. Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist
14. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist
15. C-C chemokine receptor 3 antagonism by the beta-chemokine macrophage inflammatory protein 4, a property strongly enhanced by an amino-terminal alanine-methionine swap
16. A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIIV-1 entry
17. Identification of potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration
18. The Ligands of CXC Chemokine Receptor 3, I-TAC, Mig, and IP10, Are Natural Antagonists for CCR3
19. Searching for peptide ligands with an epitope library
20. High affinity type I interleukin 1 receptor antagonists discovered by screening recombinant peptide libraries
21. Small peptides as potent mimetics of the protein hormone erythropoietin
22. Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library
23. Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3 and CCR5
24. Comparison of the structure of vMIP-II with eotaxin-1, RANTES, and MCP-3 suggests a unique mechanism for CCR3 activation
25. Blocking chemokine receptors
26. Differential regulation of eosinophil chemokine signaling via CCR3 and non-CCR3 pathways
27. Surface attachment of Salmonella typhimurium to intestinal epithelia imprints the subepithelial matrix with gradients chemotactic for neutrophils
28. Characterization of binding between the chemokine eotaxin and peptides derived from the chemokine receptor CCR3
29. Chemical synthesis, purification and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide
30. New inhibitors of Helicobacter pylori urease holoenzyme selected from phage-displayed peptide libraries
31. Chemokine receptor specific for IP10 and mig: Structure, function, and expression in activated T-lymphocytes
32. Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration