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Volumn 108, Issue 12, 2001, Pages 1745-1747

Putting the brakes on arthritis: Can suppressors of cytokine signaling (SOCS) suppress rheumatoid arthritis?

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; CYTOKINE; CYTOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 6; JANUS KINASE; REPRESSOR PROTEIN; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

EID: 0035660733     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200114661     Document Type: Note
Times cited : (13)

References (24)
  • 1
    • 0030839112 scopus 로고    scopus 로고
    • A new protein containing an SH2 domain that inhibits JAK kinases
    • (1997) Nature , vol.387 , pp. 921-924
    • Endo, T.A.1
  • 2
    • 0030792590 scopus 로고    scopus 로고
    • A family of cytokine-inducible inhibitors of signalling
    • (1997) Nature , vol.387 , pp. 917-921
    • Starr, R.1
  • 4
    • 20244389693 scopus 로고    scopus 로고
    • The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
    • (1999) EMBO J. , vol.18 , pp. 1309-1320
    • Yasukawa, H.1
  • 5
    • 0033520326 scopus 로고    scopus 로고
    • SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine
    • (1999) Cell , vol.98 , pp. 597-608
    • Alexander, W.S.1
  • 6
    • 0033520467 scopus 로고    scopus 로고
    • SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
    • (1999) Cell , vol.98 , pp. 609-616
    • Marine, J.C.1
  • 8
    • 0033520389 scopus 로고    scopus 로고
    • SOCS3 is essential in the regulation of fetal liver erythropoiesis
    • (1999) Cell , vol.98 , pp. 617-627
    • Marine, J.C.1
  • 10
    • 0026039673 scopus 로고
    • Transgenic mice expressing human tumour necrosis factor: A predictive genetic model of arthritis
    • (1991) EMBO J. , vol.10 , pp. 4025-4031
    • Keffer, J.1
  • 11
    • 0027438710 scopus 로고
    • Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor alpha
    • (1993) Arthritis Rheum. , vol.36 , pp. 1681-1690
    • Elliott, M.J.1
  • 12
    • 0013511183 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
    • (1997) N. Engl. J. Med. , vol.337 , pp. 141-147
    • Moreland, L.W.1
  • 13
    • 0032536542 scopus 로고    scopus 로고
    • Interleukin 6 is required for the development of collagen-induced arthritis
    • (1998) J. Exp. Med. , vol.187 , pp. 461-468
    • Alonzi, T.1
  • 15
    • 0035667907 scopus 로고    scopus 로고
    • Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
    • (2001) J. Clin. Invest. , vol.108 , pp. 1781-1788
    • Shouda, T.1
  • 17
    • 0032535364 scopus 로고    scopus 로고
    • The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families
    • (1998) Genes Dev. , vol.12 , pp. 3872-3881
    • Kamura, T.1
  • 18
    • 0035898315 scopus 로고    scopus 로고
    • Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation
    • (2001) J. Exp. Med. , vol.194 , pp. 189-203
    • Ernst, M.1
  • 19
    • 0035042611 scopus 로고    scopus 로고
    • SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
    • (2001) Nat. Genet. , vol.28 , pp. 29-35
    • Yoshikawa, H.1
  • 20
    • 0023849455 scopus 로고
    • Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
    • (1988) Nature , vol.332 , pp. 83-85
    • Kawano, M.1
  • 21
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS 3 as a potential mediator of central leptin resistance
    • (1998) Mol. Cell , vol.1 , pp. 619-625
    • Bjorbaek, C.1
  • 24
    • 0034729710 scopus 로고    scopus 로고
    • Gigantism in mice lacking suppressor of cytokine signalling-2
    • (2000) Nature , vol.405 , pp. 1069-1073
    • Metcalf, D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.