The pleiotropic effects of tissue factor: A possible role for factor VIIa-induced intracellular signalling?

Thrombosis and Haemostasis

Volumn 86, Issue 6, 2001, Pages 1353-1359

  Versteeg, H H ^a   Peppelenbosch, M P ^a   Spek, C A ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Angiogenesis; Atherosclerosis; Coagulation; Inflammation; Tumourigenesis

Indexed keywords

BLOOD CLOTTING FACTOR 7A; CALCIUM ION; FIBRIN; FIBRINOGEN; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; THROMBOPLASTIN;

ANGIOGENESIS; ATHEROSCLEROSIS; BLOOD CLOTTING; CALCIUM SIGNALING; CARCINOGENESIS; ENZYME ACTIVATION; FIBRIN FORMATION; HUMAN; INFLAMMATION; METASTASIS; MOLECULAR DYNAMICS; NONHUMAN; PATHOPHYSIOLOGY; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW; SEPSIS; SIGNAL TRANSDUCTION;

EID: 0035654918     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1616734     Document Type: Review

References (77)

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6. Localisation of tissue factor in the normal vessel wall and in the atherosclerotic plaque
7. Localisation of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody
8. Increased in vitro and in vivo generation of procoagulant activity (tissue factor) by mononuclear phagocytes after intralipid infusion in rabbits
9. Enhanced endothelial tissue factor but normal thrombomodulin in endotoxin-treated rabbits
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11. In situ localization of tissue factor in human atherosclerotic plaques by binding of digoxigenin-labeled factors VIIa and X
12. Oxidized low-density lipoprotein increases cultured human endothelial cell tissue factor activity and reduces protein C activation
13. Acetyl-LDL but not native and ox-LDL stimulate the expression of procoagulant activity by monocytes
14. Enhanced procoagulatory activity (PCA) of human monocytes/macrophages after in vitro stimulation with chemically modified LDL
15. 2+ mobilization and protein kinase C activation
16. Tissue factor expression in human arterial smooth muscle cells. TF is present in three cellular pools after growth factor stimulation
17. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells and macrophages; Implications for CD40-CD40 ligand signaling in atherosclerosis
18. Activation of monocyte/macrophage functions related to acute atheroma complication by ligation of CD40: Induction of collagenase, stromelysin, and tissue factor
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28. Inhibition of IL-1 induced tissue factor (TF) synthesis and procoagulant activity (PCA) in purified human monocytes by IL-4, IL-10 and IL-13
29. Interruption of vascular thrombus formation and vascular lesion formation by dietary n-3 fatty acids in fish oil in nonhuman primates
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33. Targeted disruption of the murine tissue factor gene results in embryonic lethality
34. Molecular basis of angiogenesis. Role of VEGF and VE-cadherin
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37. Requirement for binding of catalytically active factor VIIa in tissue factor dependent experimental metastasis
38. Tissue factor controls the balance of angiogenic and anti-angiogenic properties of tumour cells in mice
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41. Tissue factor-dependent vascular endothelial growth factor production by human fibroblasts in response to activated factor VII
42. Vascular endothelial growth factor production by fibroblasts in response to factor VIIa binding to tissue factor involves thrombin and factor Xa
43. Thrombin-induced increase in endothelial permeability is associated with changes in cell-to-cell junction organisation
44. Factor VIIa and thrombin induce the expression of Cyr61 and connective tissue factor, extracellular matrix signaling proteins that could act as possible downstream mediators in Factor VIIa.tissue factor-induced signal transduction
45. Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3
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47. The cytokine-mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endtoxaemia
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51. Differential effects of anti-tumour necrosis factor monoclonal antibodies on systemic inflammatory responses iin experimental endotoxemia in chimpanzees
52. Effect of a recombinant dimeric tumour necrosis factor receptor on inflammatory responses to intravenous endotoxin in normal humans
53. Recombinant tumour necrosis factor receptor p75 fusion protein (TNFR:Fc) alters endotoxin-induced activation of the kinin, fibrinolytic, and coagulation systems in normal humans
54. Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees
55. Interleukin-1 blockade attenuates mediator release and dysregulation of the hemostatic mechanism during human sepsis
56. Lethal septic shock is prevented by blocking tissue factor
57. Tissue factor pathway inhibitor (TFPI) reduces mortality from Escherichia coli septic shock
58. Tissue factor pathway inhibitor blocks cellular effects of endotoxin and interferring with transfer to CD14
59. Active site inhibited factor VIIa (DEGR VIIa) attenuates the coagulant and interleukin-6 and -8, but not tumour necrosis factor, responses of the baboon to LD100 Escherichia coli
60. Role of tissue factor in adhesion of mononuclear phagocytes to and trafficking through endothelium in vitro
61. Tissue factor and factor VIIa receptor/ligand interactions induced proinflammatory effects in macrophages
62. Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: Upregulation of poly(A) polymerase
63. Association of tissue factor with a g chain homodimer of the IgE receptor type I in cultured human monocytes
64. 2+ signals in J82 cells, transfected Cos-1 cells, Madin Darby Canine Kidney cells and in human endothelial cells, induced to synthesize tissue factor
65. 2+ oscillations in Madin-Darby Canine Kidney cells only when proteolytically active
66. Signal transduction via the mitogen activated protein kinase pathway induced by binding of coagulation factor VIIa to tissue factor
67. Factor VIIa-induced p42-44 mitogen-activated protein kinase activation requires the proteolytic activity of Factor VIIa and is independent of the tissue factor cytoplasmic domain
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69. Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, Phosphatidylinositol 3-kinase, and Rac
70. Crystal structure of the extracellular region of human tissue factor
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74. Exclusion of known protease-activated receptors in factor VIIa-induced signal transduction
75. Binding of factor VIIa to tissue factor on keratinocytes induces gene expression
76. Lipopolysaccharide-induced change of phosphorylation of two cytosolic proteins in human monocytes is prevented by inhibitors of ADP-ribosylation
77. The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumour necrosis factor