Glutamate transport and metabolism in dopaminergic neurons of substantia nigra: Implications for the pathogenesis of Parkinson's disease

Journal of Neurology, Supplement

Volumn 247, Issue 2, 2000, Pages 25-35

  Plaitakis, Andreas ^a   Shashidharan, Pullanipally ^b  

^a UNIVERSITY OF CRETE   (Greece)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Antisense oligonucleotides; Dopaminergic neurons; Glutamate dehydrogenase; Glutamate transporters; Parkinson's disease; Substantia nigra

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GLUTAMATE AMMONIA LIGASE; GLUTAMATE DEHYDROGENASE; GLUTAMATE RECEPTOR; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; NEUROTRANSMITTER; TYROSINE 3 MONOOXYGENASE;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; CONFERENCE PAPER; DOPAMINERGIC NERVE CELL; HUMAN; IN SITU HYBRIDIZATION; MESENCEPHALON; PARKINSON DISEASE; PRIORITY JOURNAL; SUBSTANTIA NIGRA; SYNAPSE; TRANSAMINATION;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; DOPAMINE; GLUTAMIC ACID; HUMANS; NEURONS; PARKINSON DISEASE; SUBSTANTIA NIGRA;

EID: 0034058324     PISSN: 09391517     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (43)

1. Aoki C, Milner TS, RexSheu K-FR, Blass JP, Pickel VM (1987) Regional distribution of astrocytes with intense immunoreactivity for glutamate dehydrogenase in rat brain: implications for neuron-glia interactions in glutamate transmissions. J Neurosci 7:2214-2231
2. Arriza JL, Eliasof S, Kavanaugh MP, Amara SG (1997) Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc Natl Acad Sci USA 94: 4155-4160
3. Arriza JL, Fairman WA, Wadiche JI, Murdoch GH, Kavanaugh MP, Amara SG (1994) Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci 14:5559-5569
4. Bladini F, Porter RH, Greenamyre T (1996) Glutamate and Parkinson's disease. Mol Neurobiol 12:73-93
5. Clements JD, Lester RAJ, Tong CE, Jahr CE (1992) The time course of glutamate in the synaptic cleft. Science 258: 1498-1501
6. Curtis DR, Watkins JC (1960) The excitation and depression of spinal neurons by structurally related amino acids. J Neurochem 6: 117-141
7. Das AT, Moerer P, Charles R, Moorman AF, Lamers WH (1989) Nucleotide sequence of rat liver glutamate dehydrogenase cDNA. Nue Acids Res 17: 2355
8. Fairman WA, Vandernberg RJ, Arriza JL, Kavanaugh MP, Amara SG (1995) An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 375:599-603
9. Fonnum F (1984) Glutamate: a neurotransmitter in mammalian brain. J Neurochem 42: 1-11
10. Gasser T, Muller-Myhsok B, Wszolek ZK, Oehlmann R, Calne BD, Bonifati V, Bereznai B, Fabrizio E, Vieregge P, Horstmann RD (1998) A susceptibility locus for Parkinson's disease maps to chromosome 2p13. Nat Genet 18:262-265
11. Johnson SW, Seutin V, North RA (1992) Burst firing in dopamine neurons induced by N-methyl-D-aspartate: role of electrogenic sodium pump. Science 258:665-667
12. Kanai Y, Hediger MA (1992) Primary structure and functional characterization of a high-affinity glutamate transporter. Nature 360:467-471
13. Lehre KP, Levy LM, Ottersen SP, Storm-Mathisen J, Danbolt NC (1995) Differential expression of two glial glutamate transporters in rat brain: quantitative and immunocytochemical observations. J Neurosci 15: 1835-1853
14. Lucas DR, Newhouse JP (1957) The toxic effect of sodium L-glutamate on the inner layer of the retina. Arch Ophthalmol 58: 193-204
15. Mavrothalassitis G, Tzimagiorgis G, Mitsialis A, Zannis VI, Plaitakis A, Papamatheakis J, Moschonas NK (1988) Isolation and characterization of cDNA clones encoding human liver glutamate dehydrogenase: evidence for a small gene family. Pro Natl Acad Sci USA 85: 3494-3498
16. Mercuri NB, Stratta F, Calabresi P, Bond A, Bernardi G (1993) Activation of metabotropic glutamate receptors induces an inward current in rat dopamine mesencephalic neurons. Neuroscience 56:399-407
17. Mytilineou C, Han S-K, Cohen G (1993) Toxic and protective effects of L-dopa on mesencephalic cultures. J Neurochem 61: 1470-1478
18. Nakanishi S (1992) Molecular diversity of glutamate receptors and implications for brain function. Science 258:597-603
19. Noblett KL, Ariano MA (1996) Co-expression of receptor mRNA and protein: striatal dopamine and excitatory amino acid subtypes. J Neurosci Methods 66:61-67
20. Ohno M, Watanabe S (1995) Persistent increase in dopamine release following activation of metabotropic glutamate receptors in the rat nucleus accumbens. Neurosci Lett 200: 113-116
21. Olney JW, Ho OL, Rhee V (1971) Cytotoxic effects of acidic and sulfur containing amino acids on the infant mouse central nervous system. Exp Brain Res 14:61-76
22. Ozawa S, Kamiya H, Tsuzuki K (1998) Glutamate receptors in mammalian central nervous system. Prog Neurobiol 54:581-618
23. Paquet M, Tremblay M, Soghomonian JJ, Smith Y (1997) AMPA and NMDA glutamate receptor subunits in midbrain dopaminergic neurons in the squirrel monkey: an immunohistochemical and in situ hybridization study. J Neurosci 17:1377-1396
24. 3H] dopamine release from rat mesencephalic cells in primary culture. J Neurochem 64:1410-1412
25. Petralia RS, Wang YX, Wenthold RJ (1994) Histological and ultrastructural localization of the kainate receptor subunits, KA2 and GluR6/7, in the rat nervous system using selective antipeptide antibodies. J Comp Neural 349:85-110
26. Pines G, Danbolt NC, Bjoras M, Zhang Y, Bendahan A, Eide L, Koepsell H, Storm-Mathisen J, Seeberg E, Kanner Bl (1992) Cloning and expression of rat brain L-glutamate transporter. Nature 360:464-467
27. Plaitaksi A (1991) Olivopontocerebellar atrophy with glutamate dehydrogenase deficiency. In: de Jong JMBV (ed) Handbook of clinical neurology, vol 16 (60) Hereditary neuropathies and spinocerebellar degenerations. Elsevier Science Publishers, Amsterdam, pp 551-568
28. Plaitakis A, Berl S, Yahr MD (1982) Abnormal glutamate metabolism in an adult-onset degenerative neurological disorder. Science 216:193-196
29. Plaitakis A, Berl S, Yahr MD (1984) Neurological disorders associated with deficiency of glutamate dehydrogenase. Ann Neurol 15:144-153
30. Polymeropoulos MH, Lavedan C, Leroy E, Ide SE, Dehejia A, Dutra A, Pike B, Root H, Rubenstein J, Boyer R, Stenroos ES, Chandrasekharappa S, Athanassiadou A, Papapetropoulos T, Johnson WG, Lazzarini AM, Duvoisin RC, Di Iorio G, Golbe LI, Nussbaum RL (1997) Mutation in the α-synuclein gene identified in families with Parkinson's disease. Science 276:2045-2047
31. Rothe F, Brosz M, and Storm-Mathisen J (1994) Quantitative ultrastructural localization of glutamate dehydrogenase in the rat cerebellar cortex. J Neurosci 62:1133-1146
32. Sato K, Kiyama H, Tohyama M (1993) The differential expression patterns of messenger RNAs encoding non-N-methyl-D-aspartate glutamate receptor subunits (GluR1-4) in the rat brain. Neuroscience 52:515-539
33. Shashidharan P, Clarke DD, Ahmed N, Plaitakis A (1997) Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP. J Neurochem 68: 1804-1811
34. Shashidharan P, Huntley GW, Meyer T, Morrison JH, Plaitakis A (1994) Neuronspecific human glutamate transporter: molecular cloning, characterization and expression in human brain. Brain Res 662:245-250
35. Shashidharan P, Huntley GW, Murray J, Walsh MJ, Buku A, Moran T, Morrison JH, Plaitakis A (1997) Immunohistochemical localization of neuron-specific glutamate transporter (EAAC1) in rat brain and spinal cord revealed by a novel monoclonal antibody. Brain Res 773:139-148
36. Shashidharan P, Michaelides TM, Robakis NK, Kretsovali A, Papamatheakis J, Plaitakis A (1994) Novel human glutamate dehydrogenase expressed in neural and testicular tissues and encoded by an X-linked intronless gene. J Biol Chem 269: 16971-16976
37. Shashidharan P, Plaitakis A (1993) Cloning and characterization of a glutamate transporter cDNA from human cerebellum. Biochim Biophys Acta 1216:161-164
38. Shashidharan P, Wittenberg I, Plaitakis A (1994) Molecular cloning of human brain glutamate/aspartate transporter II. Biochim Biophys Acta 1191:393-396
39. Standaert DG, Testa CM, Young AB, Penney J Jr (1994) Organization of N-methyl-D-aspartate glutamate receptor gene expression in the basal ganglia of the rat. J Comp Neurol 343:1-16
40. Stanley CA, Lieu YK, Hsu BYL, Burlina AB, Greenberg CR, Hopwood NJ. Perlman K, Rich BH. Zammarchi E, Poncz, M (1998) Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. N Engl J Med 338:1352-1357
41. +-dependent glutamate/aspartate transporter from rat brain. Proc Natl Acad Sci USA 89: 10955-10959
42. Testa CM, Standaert DG, Young AB, Penney J Jr (1994) Metabotropic glutamate receptor mRNA expression in the basal ganglia of the rat. J Neurosci 14: 3005-3018
43. Wenthold RJ, Trumpy VA, Zhu WS, Petralia RS (1994) Biochemical and assembly properties of OluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies. J Biol Chem 269: 1332-1339