Liposomal ATP or NAD+ protects human endothelial cells from energy failure in a cell culture model of sepsis

Research Communications in Molecular Pathology and Pharmacology

Volumn 110, Issue 1-2, 2001, Pages 107-116

  Han, Yong Y ^a   Huang, Leaf ^a   Jackson, Edwin K ^a   Dubey, Raghvendra K ^a   Gillepsie, Delbert G ^a   Carcillo, Joseph A ^a  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE LIPID COMPLEX; ENDOTOXIN; GAMMA INTERFERON; LIPOSOME; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE LIPID COMPLEX; PROTECTIVE AGENT; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CELL PROTECTION; CONTROLLED STUDY; DISEASE MODEL; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; ENCAPSULATION; ENDOTHELIUM CELL; ENERGY METABOLISM; FILM; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; PRIORITY JOURNAL; SEPSIS; TECHNIQUE;

ADENOSINE TRIPHOSPHATE; CELL CULTURE TECHNIQUES; CELL RESPIRATION; DRUG DELIVERY SYSTEMS; ENDOTHELIUM, VASCULAR; ENERGY METABOLISM; HUMANS; LIPOSOMES; MITOCHONDRIA, MUSCLE; NAD; SEPSIS;

EID: 0035559128     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Nicotinamide adenine dinucleotide splitting enzyme: A plasma membrane protein of murine macrophages
2. Rapid reduction of nitric oxide by mitochondria, and reversible inhibition of mitochondrial respiration by nitric oxide
3. Aconitase is readily inactivated by peroxynitrite, but not its precursor, nitric oxide
4. Viability measurements in mammalian cell systems
5. Rapid separation of low molecular weight solutes from liposomes without dilution
6. Interferon-γ and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells
7. Extracellular ATP: Effects, sources and fate
8. A biological method for the quantitative measurement of tetrodotoxin (TTX): Tissue culture bioassay in combination with a water-soluble tetrazolium salt
9. Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not
10. A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet
11. Liposomally-entrapped ATP: Improved efficiency against experimental brain ischemia in the rat
12. Intracarotidal administration of liposomally-entrapped ATP: Improved efficiency against experimental brain ischemia
13. Liposomal ATP protects the liver from injury during shock
14. Nitric oxide mediates lipopolysaccharide-induced alterations of mitochondrial function in cultured hepatocytes and isolated perfused liver
15. Preparation of liposomes
16. Superoxide radical scavenging prevents cellular calcium dysregulation during intraabdominal sepsis
17. Mitochondrial dysfunction in sepsis
18. DNA strand breakage, activation of poly(ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity in macrophages and smooth muscle cells exposed to peroxynitrite
19. Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly(ADP-ribose) synthetase by peroxynitrite
20. Preparation of unilamellar liposomes of intermediate size (0.1-0.2 μM) by a combination of reverse phase evaporation and extrusion through polycarbonate membranes
21. Peroxynitrite-mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide
22. Protective effects of nicotinamide against nitric oxide-mediated delayed vascular failure in endotoxic shock: Potential involvement of polyADP ribosyl synthetase
23. The potential role of peroxynitrite in the vascular contractile and cellular energy failure in endotoxic shock