Transgenic mice as a tool to study the renin-angiotensin system

Contributions to Nephrology

Volumn 135, Issue , 2001, Pages 72-91

  Tharaux, Pierre Louis ^a   Coffman, Thomas M ^a,b  

^a DUKE UNIVERSITY   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ANIMAL MODEL; ELECTROLYTE BALANCE; GENETICS; HEMODYNAMICS; KIDNEY FUNCTION TEST; MOUSE; MUTATION; PHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SENSITIVITY AND SPECIFICITY; TRANSGENIC MOUSE;

ANIMALS; HEMODYNAMIC PROCESSES; KIDNEY FUNCTION TESTS; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MUTATION; RENIN-ANGIOTENSIN SYSTEM; SENSITIVITY AND SPECIFICITY; WATER-ELECTROLYTE BALANCE;

EID: 0035538355     PISSN: 03025144     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000060158     Document Type: Article

References (105)

1. Piccini N, Knopf JL, Gross KW: A DNA polymorphism, consistent with gene duplication, correlates with high renin levels in the mouse submaxillary gland. Cell 1982;30:205-213.
2. Dickinson DP, Gross KW, Piccini N, Wilson CM: Evolution and variation of renin genes in mice. Genetics 1984;108:651-667.
3. Timmermans PB, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JA, Smith RD: Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev 1993;45:205-251.
4. Gordon JW, Ruddle FH: Integration and stable germ line transmission of genes injected into mouse pronuclei. Science 1981;214:1244-1246.
5. Evans MJ, Kaufman MH: Establishment in culture of pluripotential cells from mouse embryos. Nature 1981;292:154-156.
6. Capecchi MR: Altering the genome by homologous recombination. Science 1989;244:1288-1292.
7. Gomez RA, Lynch KR, Chevalier RL, Everett AD, Johns DW, Wilfong N, Peach MJ, Carey RM: Renin and angiotensinogen gene expression and intrarenal renin distribution during ACE inhibition. Am J Physiol 1988;254:F900-F906.
8. Gomez RA, Lynch KR, Chevalier RL, Wilfong N, Everett A, Carey RM, Peach MJ: Renin and angiotensinogen gene expression in maturing rat kidney. Am J Physiol 1988;254:F582-F587.
9. Jones CA, Sigmund CD, McGowan RA, Kane-Haas CM, Gross KW: Expression of murine renin genes during fetal development. Mol Endocrinol 1990;4:375-383.
10. Grady EF, Sechi LA, Griffin CA, Schambelan M, Kalinyak JE: Expression of AT2 receptors in the developing rat fetus. J Clin Invest 1991;88:921-933.
11. Kakuchi J, Ichiki T, Kiyama S, Hogan BL, Fogo A, Inagami T, Ichikawa I: Developmental expression of renal angiotensin II receptor genes in the mouse. Kidney Int 1995;47:140-147.
12. Kim HS, Krege JH, Kluckman KD, Hagaman JR, Hodgin JB, Best CF, Jennette JC, Coffman TM, Maeda N, Smithies O: Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci USA 1995;92:2735-2739.
13. Pryde PG, Sedman AB, Nugent CE, Barr M Jr: Angiotensin-converting enzyme inhibitor fetopathy. J Am Soc Nephrol 1993;3:1575-1582.
14. Niimura F, Labosky PA, Kakuchi J, Okubo S, Yoshida H, Oikawa T, Ichiki T, Naftilan AJ, Fogo A, Inagami T, et al: Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest 1995;96:2947-2954.
15. Esther CR Jr, Howard TE, Marino EM, Goddard JM, Capecchi MR, Bernstein KE: Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest 1996;74:953-965.
16. Krege JH, John SW, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O'Brien DA, Smithies O: Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature 1995;375:146-148.
17. Sharp MG, Fettes D, Brooker G, Clark AF, Peters J, Fleming S, Mullins JJ: Targeted inactivation of the Ren-2 gene in mice. Hypertension 1996;28:1126-1131.
18. Clark AF, Sharp MGF, Morley SD, Fleming S, Peters J, Mullins JJ: Renin-1 is essential for normal renal juxtaglomerular cell granulation and macula densa morphology. J Biol Chem 1997;272:18185-18190.
19. Yanai K, Saito T, Kakinuma Y, Kon Y, Hirota K, Taniguchi-Yanai K, Nishijo N, Shigematsu Y, Horiguchi H, Kasuya Y, et al: Renin-dependent cardiovascular functions and renin-independent blood- brain barrier functions revealed by renin-deficient mice. J Biol Chem 2000;275:5-8.
20. Esther CR, Marino EM, Howard TE, Machaud A, Corvol P, Capecchi MR, Bernstein KE: The critical role of tissue angiotensin-converting enzyme as revealed by gene targeting in mice. J Clin Invest 1997;99:2375-2385.
21. Ito M, Oliverio MI, Mannon PJ, Best CF, Maeda N, Smithies O, Coffman TM: Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proc Natl Acad Sci USA 1995;92:3521-3525.
22. Sugaya T, Nishimatsu S, Tanimoto K, Takimoto E, Yamagishi T, Imamura K, Goto S, Imaizumi K, Hisada Y, Otsuka A, et al: Angiotensin II type 1a receptor-deficient mice with hypotension and hyperreninemia. J Biol Chem 1995;270:18719-18722.
23. Matsusaka T, Nishimura H, Utsunomiya H, Kakuchi J, Niimura F, Inagami T, Fogo A, Ichikawa I: Chimeric mice carrying 'regional' targeted deletion of the angiotensin type 1A receptor gene. Evidence against the role for local angiotensin in the in vivo feedback regulation of renin synthesis in juxtaglomerular cells. J Clin Invest 1996;98:1867-1877.
24. Oliverio MI, Madsen K, Best CF, Ito M, Maeda N, Smithies O, Coffman TM: Renal growth and development in mice lacking AT1A receptors for angiotensin II. Am J Physiol 1998;274:F43-F50.
25. Chen X, Li W, Yoshida H, Tsuchida S, Nishimura H, Takemoto F, Okubo S, Fogo A, Matsusaka T, Ichikawa I: Targeting deletion of angiotensin type 1B receptor gene in the mouse. Am J Physiol 1997;272:F299-F304.
26. Ichiki T, Inagami T: Expression, genomic organization, and transcription of the mouse angiotensin II type 2 receptor gene. Circ Res 1995;76:693-700.
27. Hein L, Barsh GS, Pratt RE, Dzau VJ, Kobilka BK: Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature 1995;377:744-747.
28. MacTaggart TE, Ito M, Smithies O, John SW: Mouse angiotensin receptor genes Agtr1a and Agtr1b map to chromosomes 13 and 3. Mamm Genome 1997;8:294-295.
29. Tsuchida S, Matsusaka T, Chen X, Okubo S, Niimura F, Nishimura H, Fogo A, Utsunomiya H, Inagami T, Ichikawa I: Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. J Clin Invest 1998;101:755-760.
30. Oliverio MI, Kim HS, Ito M, Le T, Audoly L, Best CF, Hiller S, Kluckman K, Maeda N, Smithies O, et al: Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci USA 1998;95:15496-15501.
31. Gibbons GH, Pratt RE, Dzau VJ: Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II. J Clin Invest 1992;90:456-461.
32. Powell JS, Clozel JP, Muller RK, Kuhn H, Hefti F, Hosang M, Baumgartner HR: Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury. Science 1989;245:186-188.
33. Miyazaki Y, Tsuchida S, Nishimura H, Pope JC, Harris RC, McKanna JM, Inagami T, Hogan BL, Fogo A, Ichikawa I: Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest 1998;102:1489-1497.
34. Bankir L, de Rouffignac C: Urinary concentrating ability: insights from comparative anatomy. Am J Physiol 1985;249:R643-R666.
35. Oliverio MI, Delnomdedieu M, Best CF, Li P, Morris M, Callahan MF, Johnson GA, Smithies O, Coffman TM: Abnormal water metabolism in mice lacking the type 1A receptor for ANG II. Am J Physiol Renal Fluid Electrolyte Physiol 2000;278:F75-F82.
36. Krege JH, Kim HS, Moyer JS, Jennette JC, Peng L, Hiller SK, Smithies O: Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension 1997;29:150-157.
37. Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM, et al: Molecular basis of human hypertension: role of angiotensinogen. Cell 1992;71:169-180.
38. Smithies O: Theodore Cooper Memorial Lecture. A mouse view of hypertension. Hypertension 1997;30:1318-1324.
39. Bonnardeaux A, Davies E, Jeunemaitre X, Fery I, Charru A, Clauser E, Tiret L, Cambien F, Corvol P, Soubrier F: Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 1994;24:63-69.
40. Hilgers KF, Langenfeld MR, Schlaich M, Veelken R, Schmieder RE: 1166 A/C polymorphism of the angiotensin II type 1 receptor gene and the response to short-term infusion of angiotensin II. Circulation 1999;100:1394-1399.
41. Oliverio MI, Best CF, Kim HS, Arendshorst WJ, Smithies O, Coffman TM: Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. Am J Physiol 1997;272:F515-F520.
42. Llorens-Cortes C, Greenberg B, Huang H, Corvol P: Tissular expression and regulation of type 1 angiotensin II receptor subtypes by quantitative reverse transcriptase-polymerase chain reaction analysis. Hypertension 1994;24:538-548.
43. Burson JM, Aguilera G, Gross KW, Sigmund CD: Differential expression of angiotensin receptor 1A and 1B in mouse. Am J Physiol 1994;267:E260-E267.
44. Ruan X, Oliverio MI, Coffman TM, Arendshorst WJ: Renal vascular reactivity in mice: Ang II-induced vasoconstriction in AT1A receptor null mice. J Am Soc Nephrol 1999;10:2620-2630.
45. Carey RM, Wang ZQ, Siragy HM: Role of the angiotensin type 2 receptor in the regulation of blood pressure and renal function. Hypertension 2000;35:155-163.
46. Kambayashi Y, Bardhan S, Takahashi K, Tsuzuki S, Inui H, Hamakubo T, Inagami T: Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition. J Biol Chem 1993;268:24543-24546.
47. Tsutsumi Y, Matsubara H, Masaki H, Kurihara H, Murasawa S, Takai S, Miyazaki M, Nozawa Y, Ozono R, Nakagawa K. et al: Angiotensin II type 2 receptor overexpression activates the vascular kinin system and causes vasodilation. J Clin Invest 1999;104:925-935.
48. Ruan X, Oliverio MI, Coffman TM, Arendshorst WJ: Renal vascular reactivity in mice: Ang II-induced vasoconstriction in AT1A receptor null mice. J Am Soc Nephrol 1999;10:2620-2630.
49. Cervenka L, Mitchell K, Oliverio M, Coffman T, Navar L: Renal function in the AT1A receptor knockout mouse during normal and volume-expanded conditions. Kidney Int 1999;56:1855-1862.
50. Ploth DW, Rudulph J, LaGrange R, Navar LG: Tubuloglomerular feedback and single nephron function after converting enzyme inhibition in the rat. J Clin Invest 1979;64:1325-1335.
51. Schnermann JB, Traynor T, Yang T, Huang YG, Oliverio MI, Coffman T, Briggs JP: Absence of tubuloglomerular feedback responses in AT1A receptor- deficient mice. Am J Physiol 1997;273:F315-F320.
52. Traynor T, Yang T, Huang YG, Krege JH, Briggs JP, Smithies O, Schnermann J: Tubuloglomerular feedback in ACE-deficient mice. Am J Physiol 1999;276:F751-F757.
53. de Rouffignac C, Stewart J, Morel F: Micropuncture study of urine formation. IV. In the mouse undergoing salt diuresis. Nephron 1970;7:350-362.
54. Ichikawa I, Brenner BM: Importance of efferent arteriolar vascular tone in regulation of proximal tubule fluid reabsorption and glomerulotubular balance in the rat. J Clin Invest 1980;65:1192-1201.
55. Schuster VL, Kokko JP, Jacobson HR: Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules. J Clin Invest 1984;73:507-515.
56. Kojima I, Kojima K, Kreutter D, Rasmussen H: The temporal integration of the aldosterone secretory response to angiotensin occurs via two intracellular pathways. J Biol Chem 1984;259:14448-14457.
57. Oliverio MI, Best CF, Smithies O, Coffman TM: Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II. Hypertension 2000;35:550-554.
58. Gasc JM, Shanmugam S, Sibony M, Corvol P: Tissue-specific expression of type 1 angiotensin II receptor subtypes. An in situ hybridization study. Hypertension 1994;24:531-537.
59. Okubo S, Niimura F, Nishimura H, Takemoto F, Fogo A, Matsusaka T, Ichikawa I: Angiotensin-independent mechanism for aldosterone synthesis during chronic extracellular fluid volume depletion. J Clin Invest 1997;99:855-860.
60. Phillips MI: Functions of angiotensin in the central nervous system. Annu Rev Physiol 1987;49:413-435.
61. Lenkei Z, Corvol P, Llorens-Cortes C: The angiotensin receptor subtype AT1A predominates in rat forebrain areas involved in blood pressure, body fluid homeostasis and neuroendocrine control. Brain Res Mol Brain Res 1995;30:53-60.
62. Lenkei Z, Palkovits M, Corvol P, Llorens-Cortes C: Expression of angiotensin type-1 (AT1) and type-2 (AT2) receptor mRNAs in the adult rat brain: a functional neuroanatomical review. Front Neuroendocrinol 1997;18:383-439.
63. Morris M, Li P, Callahan MF, Oliverio MI, Coffman TM, Bosch SM, Diz DI: Neuroendocrine effects of dehydration in mice lacking the angiotensin AT1a receptor. Hypertension 1999;33:482-486.
64. Kihara M, Umemura S, Sumida Y, Yokoyama N, Yabana M, Nyui N, Tamura K, Murakami K, Fukamizu A, Ishii M: Genetic deficiency of angiotensinogen produces an impaired urine concentrating ability in mice. Kidney Int 1998;53:548-555.
65. Morris M, Means S, Oliverio MI, Coffman TM: Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors. Am J Physiol Regul Integr Comp Physiol 2001;280:R1177-R1184.
66. Davisson RL, Oliverio MI, Coffman TM, Sigmund CD: Divergent functions of angiotensin II receptor isoforms in the brain. J Clin Invest 2000;106:103-106.
67. Kaneto H, Morrissey J, Klahr S: Increased expression of TGF-beta 1mRNA in the obstructed kidney of rats with unilateral ureteral ligation. Kidney Int 1993;44:313-321.
68. Ishidoya S, Morrissey J, McCracken R, Klahr S: Delayed treatment with enalapril halts tubulointerstitial fibrosis in rats with obstructive nephropathy. Kidney Int 1996;49:1110-1119.
69. Ishidoya S, Morrissey J, McCracken R, Reyes A, Klahr S: Angiotensin II receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction. Kidney Int 1995;47:1285-1294.
70. Diamond JR, Anderson S: Irreversible tubulointerstitial damage associated with chronic aminonucleoside nephrosis. Amelioration by angiotensin I converting enzyme inhibition. Am J Pathol 1990;137:1323-1332.
71. Lafayette RA, Mayer G, Meyer TW: The effects of blood pressure reduction on cyclosporine nephrotoxicity in the rat. J Am Soc Nephrol 1993;3:1892-1899.
72. Michel JB, Xu Y, Blot S, Philippe M, Chatellier G: Improved survival in rats administered NG-nitro L-arginine methyl ester due to converting enzyme inhibition. J Cardiovasc Pharmacol 1996;28:142-148.
73. Maschio G, Alberti D, Janin G, Locatelli F, Mann JFE, Motolese M, Ponticelli C, Ritz E, Zucchelli P: Effect of the angiotensin-converting-enzyme inhibitor benazepril on the progression of chronic renal insufficiency. N Engl J Med 1996;334:939-945.
74. Anderson S, Meyer TW, Rennke HG, Brenner BM: Control of glomerular hypertension limits glomerular injury in rats with reduced renal mass. J Clin Invest 1985;76:612-619.
75. Border WA, Noble NA: Interactions of transforming growth factor-beta and angiotensin II in renal fibrosis. Hypertension 1998;31:181-188.
76. Johnson RJ, Alpers CE, Yoshimura A, Lombardi D, Pritzl P, Floege J, Schwartz SM: Renal injury from angiotensin II-mediated hypertension. Hypertension 1992;19:464-474.
77. Johnson RJ, Raines EW, Floege J, Yoshimura A, Pritzl P, Alpers C, Ross R: Inhibition of mesangial cell proliferation and matrix expansion in glomerulonephritis in the rat by antibody to platelet-derived growth factor. J Exp Med 1992;175:1413-1416.
78. Kohno M, Yasunari K, Yokokawa K, Murakawa K, Horio T, Takeda T: Inhibition by atrial and brain natriuretic peptides of endothelin-1 secretion after stimulation with angiotensin II and thrombin of cultured human endothelial cells. J Clin Invest 1991;87:1999-2004.
79. Boffa JJ, Tharaux PL, Placier S, Ardaillou R, Dussaule JC, Chatziantoniou C: Angiotensin II activates collagen type I gene in the renal vasculature of transgenic mice during inhibition of nitric oxide synthesis: Evidence for an endothelin-mediated mechanism. Circulation 1999;100:1901-1908.
80. Chung KH, Gomez RA, Chevalier RL: Regulation of renal growth factors and clusterin by AT1 receptors during neonatal ureteral obstruction. Am J Physiol 1995;268:F1117-F1123.
81. 81a Ma L, Nakamura S, Whitsitt J, Marcantoni C, Davidson J, Fogo A: Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1. Kidney Int 2000;58:2425-2436.
82. 81b Fern RJ, Yesko CM, Thornhill BA, Kim HS, Smithies O, Chevalier RL: Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice. J Clin Invest 1999;103:39-45.
83. Satoh M, Kashihara N, Yamasaki Y, Maruyama K, Okamoto K, Maeshima Y, Sugiyama H, Sugaya T, Murakami K, Makino H: Renal interstitial fibrosis is reduced in angiotensin II type 1a receptor-deficient mice. J Am Soc Nephrol 2001;12:317-325.
84. Ma J, Nishimura H, Fogo A, Kon V, Inagami T, Ichikawa I: Accelerated fibrosis and collagen deposition develop in the renal interstitium of angiotensin type 2 receptor null mutant mice during ureteral obstruction. Kidney Int 1998;53:937-944.
85. Sadoshima J, Xu Y, Slayter HS, Izumo S: Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 1993;75:977-984.
86. Dixon IM, Ju H, Reid NL, Scammell-La Fleur T, Werner JP, Jasmin G: Cardiac collagen remodeling in the cardiomyopathic Syrian hamster and the effect of losartan. J Mol Cell Cardiol 1997;29:1837-1850.
87. Harada K, Komuro I, Shiojima I, Hayashi D, Kudoh S, Mizuno T, Kijima K, Matsubara H, Sugaya T, Murakami K, et al: Pressure overload induces cardiac hypertrophy in angiotensin II type 1A receptor knockout mice. Circulation 1998;97:1952-1959.
88. Kudoh S, Komuro I, Hiroi Y, Zou Y, Harada K, Sugaya T, Takekoshi N, Murakami K, Kadowaki T, Yazaki Y: Mechanical stretch induces hypertrophic responses in cardiac myocytes of angiotensin II type 1a receptor knockout mice. J Biol Chem 1998;273:24037-24043.
89. Hamawaki M, Coffman TM, Lashus A, Koide M, Zile MR, Oliverio MI, DeFreyte G, Cooper Gt, Carabello BA: Pressure-overload hypertrophy is unabated in mice devoid of AT1A receptors. Am J Physiol 1998;274:H868-H873.
90. Matsusaka T, Katori H, Inagami T, Fogo A, Ichikawa I: Communication between myocytes and fibroblasts in cardiac remodeling in angiotensin chimeric mice. J Clin Invest 1999;103:1451-1458.
91. Paradis P, Dali-Youcef N, Paradis FW, Thibault G, Nemer M: Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Proc Natl Acad Sci USA 2000;97:931-936.
92. Harada K, Sugaya T, Murakami K, Yazaki Y, Komuro I: Angiotensin II type 1A receptor knockout mice display less left ventricular remodeling and improved survival after myocardial infarction. Circulation 1999;100:2093-2099.
93. Harada K, Komuro I, Hayashi D, Sugaya T, Murakami K, Yazaki Y: Angiotensin II type 1a receptor is involved in the occurrence of reperfusion arrhythmias. Circulation 1998;97:315-317.
94. Iwai N, Inagami T, Ohmichi N, Kinoshita M: Renin is expressed in rat macrophage/monocyte cells. Hypertension 1996;27:399-403.
95. Gomez RA, Norling LL, Wilfong N, Isakson P, Lynch KR, Hock R, Quesenberry P: Leukocytes synthesize angiotensinogen. Hypertension 1993;21:470-475.
96. Friedland J, Setton C, Silverstein E: Induction of angiotensin converting enzyme in human monocytes in culture. Biochem Biophys Res Commun 1978;83:843-849.
97. Costerousse O, Allegrini J, Lopez M, Alhenc-Gelas F: Angiotensin I-converting enzyme in human circulating mononuclear cells: Genetic polymorphism of expression in T-lymphocytes. Biochem J 1993;290:33-40.
98. Strawn WB, Gallagher PE, Tallant EA, Ganten D, Ferrario CM: Angiotensin II AT1-receptor blockade inhibits monocyte activation and adherence in transgenic (mRen2)27 rats. J Cardiovasc Pharmacol 1999;33:341-351.
99. Furuta H, Guo DF, Inagami T: Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor. Biochem Biophys Res Commun 1992;183:8-13.
100. Tanaka A, Matsumori A, Wang W, Sasayama S: An angiotensin II receptor antagonist reduces myocardial damage in an animal model of myocarditis. Circulation 1994;90:2051-2055.
101. Furukawa Y, Matsumori A, Hirozane T, Sasayama S: Angiotensin II receptor antagonist TCV-116 reduces graft coronary artery disease and preserves graft status in a murine model. A comparative study with captopril. Circulation 1996;93:333-339.
102. Nataraj C, Oliverio MI, Mannon RB, Mannon PJ, Audoly LP, Amuchastegui CS, Ruiz P, Smithies O, Coffman TM: Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. J Clin Invest 1999;104:1693-1701.
103. Nicoletti A, Heudes D, Mandet C, Hinglais N, Bariety J, Michel JB: Inflammatory cells and myocardial fibrosis: Spatial and temporal distribution in renovascular hypertensive rats. Cardiovasc Res 1996;32:1096-1107.
104. Katoh M, Egashira K, Kataoka C, Usui M, Koyanagi M, Kitamoto S, Ohmachi Y, Takeshita A, Narita H: Regression by ACE inhibition of arteriosclerotic changes induced by chronic blockade of NO synthesis in rats. Am J Physiol Heart Circ Physiol 2001;280:H2306-H2312.
105. Nicoletti A, Mandet C, Challah M, Bariety J, Michel JB: Mediators of perivascular inflammation in the left ventricle of renovascular hypertensive rats. Cardiovasc Res 1996;31:585-595.